Gene's Nitric Oxide Stack

Many have used this stack for massive hard pumps in the gym, significant vascularity and excellent erectile function not discounting the health benefits. If you're looking for any of these benefits and more...give it a try!

Nitric Oxide Stack
Bed Time
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)


Morning
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)

Afternoon
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)

More Than a Muscle Pump: The Surprising Science of the Nitric Oxide Stack​

In the biohacking world, we often chase complex peptides or experimental compounds, but we frequently overlook the most fundamental currency of life: blood flow. In the quest for longevity, systemic vascular efficiency is the baseline upon which all other health markers are built. As we age, our ability to maintain vasodilatory capacity diminishes, impacting everything from cognitive sharpness to metabolic health. "Gene’s Nitric Oxide Stack," a protocol born and refined within the ExcelMale community, has emerged as a definitive solution for men seeking to optimize this system. This isn't just a gym supplement routine; it is a sophisticated approach to anti-aging that leverages amino acids and targeted pharmaceutical interventions to restore the body’s most vital delivery mechanism.

Beyond the Mirror: The Science of the Sustained Pump​

For the average gym-goer, the "pump" is a transient aesthetic goal—a fleeting moment of muscle fullness. However, for a longevity specialist, a "harder pump" and increased vascularity are indicators of high-functioning endothelial health. The Nitric Oxide Stack is engineered to produce a state of vasodilation that doesn't simply vanish when you rack the weights.

By optimizing the nitric oxide signaling pathway, this protocol facilitates a sustained pump that carries through your daily life. This is a critical distinction: the visual vascularity is a proxy for your body’s ability to keep its "pipes" open. When you maintain that fullness hours after a workout, you are essentially providing proof of concept that your circulatory system is operating at peak efficiency, ensuring constant nutrient delivery to peripheral tissues.

The Foundation of Performance: Hard Science for Sexual Vitality​

One of the most immediate benefits of systemic vasodilation is the restoration of sexual function. From a clinical perspective, erection quality is often the "canary in the coal mine" for cardiovascular health. Because the Nitric Oxide Stack focuses on the root physiological requirements of performance—blood flow and retention—it provides a robust alternative to temporary fixes.

A Serious Solution for Erection Quality and Duration

This stack addresses both the quality and the duration of erections with clinical precision. For men navigating the aging process, this is not a matter of vanity, but of maintaining vital physiological function. By ensuring the vascular system can respond effectively to neurological signals, the protocol allows for a level of performance that many mistakenly believe is lost to time.

The Ultimate Nootropic: Future-Proofing the Neocortex​

Perhaps the most compelling argument for nitric oxide optimization is the "bodybuilder to brain health" pipeline. While most men start this stack for its physical benefits, they are unknowingly deploying a powerful shield against age-related cognitive decline. As we age, the micro-vasculature within the brain tends to narrow and tighten, a process that starves the brain of oxygen and is a primary driver of age-related dementia.

The stack acts as a nootropic by ensuring that the brain's smallest vessels remain dilated and resilient. This ensures that the neocortex and other critical regions receive a constant supply of the nutrients required for cognitive longevity. As the source material highlights:

"by increasing nitric oxide and getting that vascular dilation we're getting oxygen blood and nutrients in the areas of the brain that can provide us with a great anti-aging benefit in terms of neurological health."

The irony is profound: a protocol often associated with the bicep curl may actually be one of your most effective tools for protecting your mind.

Systemic Management: Blood Pressure and Prostate Function​

The benefits of the stack extend into the deeper mechanics of men’s health, specifically regarding the relaxation of smooth muscle tissue. This is particularly relevant for Benign Prostate Hyperplasia (BPH) and blood pressure management. Nitric oxide serves as a signal for these tissues to relax, directly easing the "inability to ease the problems" that typically characterize age-related prostate issues.

The secondary physiological advantages of this systemic relaxation include:

• Vascular Tension Reduction: Significant support for maintaining healthy blood pressure levels by reducing resistance within the arterial walls.
• Prostate Relief: Improvement in quality of life by relaxing the prostatic smooth muscle, easing the mechanical symptoms of BPH.
• Reduced Cardiac Load: By improving systemic flow, the heart is not required to pump against the same level of resistance, preserving cardiovascular longevity.

The Future of Your Vascular Health​

"Gene’s Nitric Oxide Stack" is far from a theoretical exercise; it is a "living protocol" backed by years of community peer-review within the ExcelMale community. The "enormously long" and widely viewed thread on ExcelMale.com serves as a testament to the real-world efficacy of this stack, offering a repository of shared experiences and optimization strategies.

This multi-front approach to anti-aging represents the best of biohacking: using fundamental biological pathways to solve complex aging problems. By focusing on the delivery system itself, we can protect our brains, our hearts, and our vitality simultaneously.

If blood flow is the delivery system for every nutrient your body needs, what happens to your longevity when you finally optimize that system?


More on Nitric Oxide in Men:

Nitric Oxide Pages

 

Did you switch to doxazosin? or just no alpha blocker?

doxazosin severely affected my equilibrium

 

Did you switch to a different prescription or stop altogether and how is that affected peeing at night?

I found Flomax (Tamsulosin) to be a terrible drug for me. The side effects were horrible, including retrograde ejaculation and delayed orgasm sometimes anorgasmia; along with the other side effects commonly associated with Flomax. And, I did not find that it improved my BPH symptoms. When I switched to 5mg tadalafil daily along with 4 mg of terazosin I no longer had those issues. Everyone is different though.

 

My only problem with this is cialis, I get heartburn,or acid reflus,or whatever you want to call it. Any suggestion?

 

My only problem with this is cialis, I get heartburn,or acid reflus,or whatever you want to call it. Any suggestion?

Start very low dose, over time increase dose. It did work for me but it was a very gradual increase. Took at least a year.

 

Thanks, I’ll give it a try.

 

Question for Gene and others doing the stack:

I'm assuming the bed time dose is taken right before sleep. What time is that appx?

How many hours before that is your last meal of the day?

Thanks!

 

I didn’t follow Gene’s srack ingredients, I omitted the last three items, but the results were still pretty amazing. I was having some issues with erections from Trimix not lasting long enough, so I augmented with 50 mg of viagra and increased the Trimix from 20 to 40 ml. That worked ok, with the ingredients in Gene’s stack wow! I think in the future I can omit the viagra and reduce the Trimix to 20 ml. My blood pressure was 104/58 scary low. My normal blood pressure is 140/70. Not bad for 91.

 

I think I should be more specific about what I omitted from Gene’s stack. Horny goat weed, pycnogenol, Doxazosi. I plan on adding the horny goat weed and cialis.

 

I take Telmisartan at bedtime, should I still take tadalafil and l-citrulline with it?

 

After 6 years of having ED issues and believing it was mostly due to inadequate testosterone levels etc. I tried 5mg of cialis... and I was more touchy feely with my girl than ever before. Point being... forget about erection strength etc... what does it actually do for you mentally? Does it increase Nitric Oxide?

When I tried Cialis about 3 years ago (20 mg version) it gave me massive upper leg pains. Hard to describe... just constant aches for 24 hours straight. While I was just concentrating on erection strength... I never concentrated on other areas of the body... as to what this pill gives you.

The funny thing with the 5mg version of Cialis and even the 2.5 mg version.... I don't necessarily feel "in the mood" right after taking the pill. I actually feel more in the mood the day after. And minimal to zero side effects the day after. For example... even the 5mg version gives me headaches now... right after taking it. But 24 hours later headaches are gone... and it still gives you a decent erection.

I'm a true believer that low Nitric Oxide levels cause more issues with ED than anything else. If only we could take these crazy side effects out of the equation... it's a wonder drug. As for over the counter supplements like L-Arginine and L-Citrulline it doesn't give me anything except massive side effects. At least I know Cialis works with low doses... now only if I could dial this in more... with no side effects. Anyone know how to reduce or eliminate the side effects?

My entire life I've never had side effects to anything. Funny how we get older.... everything bothers you. lol smh. Life is crazy. But everyone should be looking closely into Nitric Oxide levels.

 

Lots of things can increase nitric oxide. You can even test yourself simply, safely and affordably at home with nitric oxide (sic) test strips.

You may be able to take a daily 2.5 mg and your symptoms may go away after a few weeks.

You may have to add some nutritional supplements to get your nitric oxide to an optimal level in addition to using the Cialis.

 

After 6 years of having ED issues and believing it was mostly due to inadequate testosterone levels etc. I tried 5mg of cialis... and I was more touchy feely with my girl than ever before. Point being... forget about erection strength etc... what does it actually do for you mentally? Does it increase Nitric Oxide?

When I tried Cialis about 3 years ago (20 mg version) it gave me massive upper leg pains. Hard to describe... just constant aches for 24 hours straight. While I was just concentrating on erection strength... I never concentrated on other areas of the body... as to what this pill gives you.

The funny thing with the 5mg version of Cialis and even the 2.5 mg version.... I don't necessarily feel "in the mood" right after taking the pill. I actually feel more in the mood the day after. And minimal to zero side effects the day after. For example... even the 5mg version gives me headaches now... right after taking it. But 24 hours later headaches are gone... and it still gives you a decent erection.

I'm a true believer that low Nitric Oxide levels cause more issues with ED than anything else. If only we could take these crazy side effects out of the equation... it's a wonder drug. As for over the counter supplements like L-Arginine and L-Citrulline it doesn't give me anything except massive side effects. At least I know Cialis works with low doses... now only if I could dial this in more... with no side effects. Anyone know how to reduce or eliminate the side effects?

My entire life I've never had side effects to anything. Funny how we get older.... everything bothers you. lol smh. Life is crazy. But everyone should be looking closely into Nitric Oxide levels.

I use 5mg and initially I got terrible low back pain, but it went away after a week or so , so perhaps your headaches will diminish as well. Good luck with it.

 

Lots of things can increase nitric oxide. You can even test yourself simply, safely and affordably at home with nitric oxide (sic) test strips.

You may be able to take a daily 2.5 mg and your symptoms may go away after a few weeks.

You may have to add some nutritional supplements to get your nitric oxide to an optimal level in addition to using the Cialis.

What nutritional supplements do you recommend? Tx

 

I ordered a bunch of 20MG Cialis and I'm not sure what I'm getting out of it. i still end up more often than not trying a 100MG Sildenafil or one of the under the tongue versions, (like 125MG).

I view these things as hacks right now trying to get it straight so it's not a huge deal. Also I have Trimix and seems like a minimum of .10 ml gets me going but sometimes a little too hard as it hurts a bit (Girthy as hell).

But my girlfriend, 20 years my juinor goes nuts when I do Trimix. I want to lower my Trimix but hate wasting a "shot day" to find out I didn't use enough. Everything else I take seems hit and miss or time of day. My weight is the lowest it's been 30 years. Right about 210, 6'-1/2". Sometimes I don't need anything particularly early in the morning or mid-afternoon.

Looks like for the NO benefits 20 MG Cialis is probably too much then is that how most of you handle this?

 

I ordered a bunch of 20MG Cialis and I'm not sure what I'm getting out of it. i still end up more often than not trying a 100MG Sildenafil or one of the under the tongue versions, (like 125MG).

I view these things as hacks right now trying to get it straight so it's not a huge deal. Also I have Trimix and seems like a minimum of .10 ml gets me going but sometimes a little too hard as it hurts a bit (Girthy as hell).

But my girlfriend, 20 years my juinor goes nuts when I do Trimix. I want to lower my Trimix but hate wasting a "shot day" to find out I didn't use enough. Everything else I take seems hit and miss or time of day. My weight is the lowest it's been 30 years. Right about 210, 6'-1/2". Sometimes I don't need anything particularly early in the morning or mid-afternoon.

Looks like for the NO benefits 20 MG Cialis is probably too much then is that how most of you handle this?

20 mg can be a bit much. I talke 2.5 mg. or 5 mg. Both doses- along with maybe 10 or 20 mgs viagra can do the trick for me

 

I started researching and taking NO boosters a couple of months ago, so take my input with a grain of salt.
I came upon a researcher/promoter named Nathan S. Bryan. He is a PHD that worked with the gentleman who discovered NO.
Apparently there are two (at least) pathways for the body to product Nitric Oxide. I don't recall the specific names but one path is through the endothelium, and that pathway uses Arginine. According to some published studies however, taking Arginine orally is not an effective way to boost NO because the stomach breaks down the Arginine and it therefore cannot be used to make NO. L-Citrulline converts to Arginine (I think in the Kidneys) and is much more bioavailable than Arginine taken orally.

The other path is the Nitrate-Nitrite path and converts nitrates consumed in foods into nitrites. Those nitrites make their way to the mouth (though saliva?) and if the mouth flora is in good order, will convert to NO.

The problem, according to Bryan, is that mouth flora is killed by fluoride. This eliminates the effectiveness of the Nitrate-Nitrite path to creating NO.

Bryan has a product (of course he does) that chemically creates NO in your mouth as it dissolves. Without the need for any bodily support other than saliva.

So I started taking that lozenge a month ago along with L-citrulline and fermented beet root powder.

Note: I've been on 10mg Cialis for a couple of years.

Morning: Lozenge
Mid-afternoon or preworkout: Fermented beet root powder and L-Citrulline
Evening: Lozenge

My goals are improved health/cardiac function/longevity. There is a lot of research on NO that seems to point to it's lack as the causal or contributing effect to many or most aging related diseases.

I hope this was useful in some way. Apologies if I rambled.

 

I started researching and taking NO boosters a couple of months ago, so take my input with a grain of salt.
I came upon a researcher/promoter named Nathan S. Bryan. He is a PHD that worked with the gentleman who discovered NO.
Apparently there are two (at least) pathways for the body to product Nitric Oxide. I don't recall the specific names but one path is through the endothelium, and that pathway uses Arginine. According to some published studies however, taking Arginine orally is not an effective way to boost NO because the stomach breaks down the Arginine and it therefore cannot be used to make NO. L-Citrulline converts to Arginine (I think in the Kidneys) and is much more bioavailable than Arginine taken orally.

The other path is the Nitrate-Nitrite path and converts nitrates consumed in foods into nitrites. Those nitrites make their way to the mouth (though saliva?) and if the mouth flora is in good order, will convert to NO.

The problem, according to Bryan, is that mouth flora is killed by fluoride. This eliminates the effectiveness of the Nitrate-Nitrite path to creating NO.

Bryan has a product (of course he does) that chemically creates NO in your mouth as it dissolves. Without the need for any bodily support other than saliva.

So I started taking that lozenge a month ago along with L-citrulline and fermented beet root powder.

Note: I've been on 10mg Cialis for a couple of years.

Morning: Lozenge
Mid-afternoon or preworkout: Fermented beet root powder and L-Citrulline
Evening: Lozenge

My goals are improved health/cardiac function/longevity. There is a lot of research on NO that seems to point to it's lack as the causal or contributing effect to many or most aging related diseases.

I hope this was useful in some way. Apologies if I rambled.

I also take 500mgs of arginine almost daily and I have seen a boost. Maybe it is slightly bioavailable?

 

I also take 500mgs of arginine almost daily and I have seen a boost. Maybe it is slightly bioavailable?

I didn't mean to imply that it has no bioavailability. I should have chosen my words more carefully.

L-citrulline, a natural precursor of L-arginine, is more bioavailable than L-arginine because it avoids hepatic first-pass metabolism and has a longer circulation time.

 

I started researching and taking NO boosters a couple of months ago, so take my input with a grain of salt.
I came upon a researcher/promoter named Nathan S. Bryan. He is a PHD that worked with the gentleman who discovered NO.
Apparently there are two (at least) pathways for the body to product Nitric Oxide. I don't recall the specific names but one path is through the endothelium, and that pathway uses Arginine. According to some published studies however, taking Arginine orally is not an effective way to boost NO because the stomach breaks down the Arginine and it therefore cannot be used to make NO. L-Citrulline converts to Arginine (I think in the Kidneys) and is much more bioavailable than Arginine taken orally.

The other path is the Nitrate-Nitrite path and converts nitrates consumed in foods into nitrites. Those nitrites make their way to the mouth (though saliva?) and if the mouth flora is in good order, will convert to NO.

The problem, according to Bryan, is that mouth flora is killed by fluoride. This eliminates the effectiveness of the Nitrate-Nitrite path to creating NO.

Bryan has a product (of course he does) that chemically creates NO in your mouth as it dissolves. Without the need for any bodily support other than saliva.

So I started taking that lozenge a month ago along with L-citrulline and fermented beet root powder.

Note: I've been on 10mg Cialis for a couple of years.

Morning: Lozenge
Mid-afternoon or preworkout: Fermented beet root powder and L-Citrulline
Evening: Lozenge

My goals are improved health/cardiac function/longevity. There is a lot of research on NO that seems to point to it's lack as the causal or contributing effect to many or most aging related diseases.

I hope this was useful in some way. Apologies if I rambled.

Is the Lozenge Neo40?

 

Is the Lozenge Neo40?

N1O1. It works well. I think the beet powder and citrine also work very well.