Gene's Nitric Oxide Stack

Many have used this stack for massive hard pumps in the gym, significant vascularity and excellent erectile function not discounting the health benefits. If you're looking for any of these benefits and more...give it a try!

Nitric Oxide Stack
Bed Time
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)


Morning
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)

Afternoon
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)

More Than a Muscle Pump: The Surprising Science of the Nitric Oxide Stack​

In the biohacking world, we often chase complex peptides or experimental compounds, but we frequently overlook the most fundamental currency of life: blood flow. In the quest for longevity, systemic vascular efficiency is the baseline upon which all other health markers are built. As we age, our ability to maintain vasodilatory capacity diminishes, impacting everything from cognitive sharpness to metabolic health. "Gene’s Nitric Oxide Stack," a protocol born and refined within the ExcelMale community, has emerged as a definitive solution for men seeking to optimize this system. This isn't just a gym supplement routine; it is a sophisticated approach to anti-aging that leverages amino acids and targeted pharmaceutical interventions to restore the body’s most vital delivery mechanism.

Beyond the Mirror: The Science of the Sustained Pump​

For the average gym-goer, the "pump" is a transient aesthetic goal—a fleeting moment of muscle fullness. However, for a longevity specialist, a "harder pump" and increased vascularity are indicators of high-functioning endothelial health. The Nitric Oxide Stack is engineered to produce a state of vasodilation that doesn't simply vanish when you rack the weights.

By optimizing the nitric oxide signaling pathway, this protocol facilitates a sustained pump that carries through your daily life. This is a critical distinction: the visual vascularity is a proxy for your body’s ability to keep its "pipes" open. When you maintain that fullness hours after a workout, you are essentially providing proof of concept that your circulatory system is operating at peak efficiency, ensuring constant nutrient delivery to peripheral tissues.

The Foundation of Performance: Hard Science for Sexual Vitality​

One of the most immediate benefits of systemic vasodilation is the restoration of sexual function. From a clinical perspective, erection quality is often the "canary in the coal mine" for cardiovascular health. Because the Nitric Oxide Stack focuses on the root physiological requirements of performance—blood flow and retention—it provides a robust alternative to temporary fixes.

A Serious Solution for Erection Quality and Duration

This stack addresses both the quality and the duration of erections with clinical precision. For men navigating the aging process, this is not a matter of vanity, but of maintaining vital physiological function. By ensuring the vascular system can respond effectively to neurological signals, the protocol allows for a level of performance that many mistakenly believe is lost to time.

The Ultimate Nootropic: Future-Proofing the Neocortex​

Perhaps the most compelling argument for nitric oxide optimization is the "bodybuilder to brain health" pipeline. While most men start this stack for its physical benefits, they are unknowingly deploying a powerful shield against age-related cognitive decline. As we age, the micro-vasculature within the brain tends to narrow and tighten, a process that starves the brain of oxygen and is a primary driver of age-related dementia.

The stack acts as a nootropic by ensuring that the brain's smallest vessels remain dilated and resilient. This ensures that the neocortex and other critical regions receive a constant supply of the nutrients required for cognitive longevity. As the source material highlights:

"by increasing nitric oxide and getting that vascular dilation we're getting oxygen blood and nutrients in the areas of the brain that can provide us with a great anti-aging benefit in terms of neurological health."

The irony is profound: a protocol often associated with the bicep curl may actually be one of your most effective tools for protecting your mind.

Systemic Management: Blood Pressure and Prostate Function​

The benefits of the stack extend into the deeper mechanics of men’s health, specifically regarding the relaxation of smooth muscle tissue. This is particularly relevant for Benign Prostate Hyperplasia (BPH) and blood pressure management. Nitric oxide serves as a signal for these tissues to relax, directly easing the "inability to ease the problems" that typically characterize age-related prostate issues.

The secondary physiological advantages of this systemic relaxation include:

• Vascular Tension Reduction: Significant support for maintaining healthy blood pressure levels by reducing resistance within the arterial walls.
• Prostate Relief: Improvement in quality of life by relaxing the prostatic smooth muscle, easing the mechanical symptoms of BPH.
• Reduced Cardiac Load: By improving systemic flow, the heart is not required to pump against the same level of resistance, preserving cardiovascular longevity.

The Future of Your Vascular Health​

"Gene’s Nitric Oxide Stack" is far from a theoretical exercise; it is a "living protocol" backed by years of community peer-review within the ExcelMale community. The "enormously long" and widely viewed thread on ExcelMale.com serves as a testament to the real-world efficacy of this stack, offering a repository of shared experiences and optimization strategies.

This multi-front approach to anti-aging represents the best of biohacking: using fundamental biological pathways to solve complex aging problems. By focusing on the delivery system itself, we can protect our brains, our hearts, and our vitality simultaneously.

If blood flow is the delivery system for every nutrient your body needs, what happens to your longevity when you finally optimize that system?


More on Nitric Oxide in Men:

Nitric Oxide Pages

 

Gene I have a question. I finally got Doxazosin in and need to ask at what time do you take it? If I understand you take 1 mg in the morning and 1 at night is that correct? Also, how long does it take to work?

That's how it is prescribed for me. I take it along with 5 mg of Tadalafil as well.

 

I tried it and it makes me extremely tired and stuffy. Glad HCG+cialis+TRT work

 

hi Gene, I looked up Doxazosin doesnt it do the same thing as Tadalafil? I am confused as to why you would need both.
http://www.mayoclinic.com/health/drug-information/DR600579

I am learning so much reading all the good info on the site. Just love the clear honesty that is here.

 

Some men can respond to Doxazosin alone. I did not.

Here is an interesting study comparing high blood pressure medications and their effect on erectile function.

The link between high blood pressure and ED is complex because ED is a side-effect of certain medications prescribed for hypertension.This was best illustrated by the Treatment of Mild Hypertension Study (TOMHS) that included 557 hypertensive men aged 45-69 years. They received a placebo or one of five drugs: acebutolol, amlodipine, chlorthalidone, doxazosin or enalapril. Sexual function was assessed at baseline and annually during follow-up (48 months). At baseline, 14.4% of the men reported problems with sexual function. ED was positively related to age, systolic blood pressure and previous use of an anti-hypertensive agent.

This a-blocker is probably the anti-hypertensive with the best-documented beneficial effect on erectile function. In TOMHS, the incidence of ED was lowest in patients using doxazosin and highest in those on chlorthalidone (a thiazide-like diuretic). The disappearance of ED was greater in the doxazosin group (87.5%) than for all the other drugs combined (55%). However, this effect did not achieve statistical significance.

Reference:

Grimm RH Jr, Grandis GA, Prineas RJ et al. for the TOMHS Research Group. Long-term effects on sexual function of five antihypertensive drugs and nutritional hygienic treatment in hypertensive men and women. Treatment of Mild Hypertension Study (TOHMS). Hypertension 1997;29:8-14

 

hi Gene, I looked up Doxazosin doesnt it do the same thing as Tadalafil? I am confused as to why you would need both.
http://www.mayoclinic.com/health/drug-information/DR600579

I am learning so much reading all the good info on the site. Just love the clear honesty that is here.

To keep it simple; the alpha blocker relaxes the smooth muscle tissues in the penis while the PDE5i increases NO so combined it has a great effect on penis erection quality and vascularity.

 

I see now, so a 1,2 punch. .
I found this article on the "Pharmacology of Penile Erection" today and seems like good reading so far. http://pharmrev.aspetjournals.org/content/53/3/417.full

 

Gene, I thought I would update on the NO stack. I started about a week ago just as you describe and today i woke up with an erection that I haven't had in the last 10 years. I will keep updating but anyone having erection problems should seriously consider this.

 

Gene, I thought I would update on the NO stack. I started about a week ago just as you describe and today i woke up with an erection that I haven't had in the last 10 years. I will keep updating but anyone having erection problems should seriously consider this.

Glade to hear John; like I said, it has had the same effect for many men and it's super healthy for a man as well!

 

Gene, I thought I would update on the NO stack. I started about a week ago just as you describe and today i woke up with an erection that I haven't had in the last 10 years. I will keep updating but anyone having erection problems should seriously consider this.

Great news BigJohn. I am getting the stack today less the alpha blocker and Tadalafil. I have to order the Tadalafil and SecureTabs only takes Visa . Hopefully I will have good results with those two missing.

 

SoCalSurfer, you will. I'm doing the same, like you no Cialis (I'm waiting for them from secure tabs) and I use Vasotec for my high blood pressure. It work super....just like Gene described

 

Hi guys! I am new to the forum and have followed this thread for a few days now. This is my first post so bare with me!... I am 46 years old and fairly active ( 5'-11"/185# lift weights and play basketball 3-4 days/wk) but am no serious bodybuilder. I am borderline high blood pressure and experiencing ED. Having read about the benefits before I have tried l-arganine and pycnogenol previously and after seeing this thread am now trying a reduced version of the stack mentioned.
I am only taking a 5g l-arganine/300mg l-citrulline/5000iu vitamin D powder in the morning around 10am then 2.5 or 5mg of Tedalifil in the evening along with regular vitamins (vitamin C, b-complex, omega 3 and Zinc) during the day. But after 4 or 5 days of the L-arganine I get a dizzy/panicked feeling and assume it is messing with my blood pressure? Is this common? Does it go away? Should I spread out the dosage of l-arganine? Thanks in advance for your advice and responses!!

 

Thanks Carlos, I dont have high blood pressure so I am not taking anything for that, but glad to hear it will work good. wife will be happy LOL.

 

Hi guys! I am new to the forum and have followed this thread for a few days now. This is my first post so bare with me!... I am 46 years old and fairly active ( 5'-11"/185# lift weights and play basketball 3-4 days/wk) but am no serious bodybuilder. I am borderline high blood pressure and experiencing ED. Having read about the benefits before I have tried l-arganine and pycnogenol previously and after seeing this thread am now trying a reduced version of the stack mentioned.
I am only taking a 5g l-arganine/300mg l-citrulline/5000iu vitamin D powder in the morning around 10am then 2.5 or 5mg of Tedalifil in the evening along with regular vitamins (vitamin C, b-complex, omega 3 and Zinc) during the day. But after 4 or 5 days of the L-arganine I get a dizzy/panicked feeling and assume it is messing with my blood pressure? Is this common? Does it go away? Should I spread out the dosage of l-arganine? Thanks in advance for your advice and responses!!

It's hard to tell what's causing these symptoms.

Oral arginine at these doses are very safe and low/no symptoms...but we're all different and respond differently.

How long have you been taking the Tadalafil?

 

Hi Gene!.......I have been taking the Tadalafil for a little over a month (usually just 2.5mg daily) with very good success in the bedroom. I was just hoping to get an extra "boost" there as well as the high blood pressure, workout and over all health benefits that I have read about SO many times with l-arganine, Pycogenol and l-citrulline......maybe I should split the dosage into two smaller ones spread out during the day for a while? Maybe 5g/day was just too much for my body?.....what more can anyone tell me about Doxazosin?

 

Gentlemen,
This thread is epic and I love but …I can’t stress it enough!!! Please make sure if you are using any of these medications that they are used under a physician’s care.

 

@Tinman, The dizziness sounds like a drop in blood pressure. Have you discussed this with your physician? If not, I would highly recommended it.

 

@Keith Willse, that is my thinking (lowering blood pressure) but why? I am taking a very small amount compared to many? And I am borderline high blood pressure! (Usually in the 128/89 range) Maybe NO in my blood is not the problem? Can you have too much?......my doctor prescribed the Tadalafil and is aware of all supplements I take. I update him regularly. But when commenting about my vitamin/supplement regiment he says he has no "opinion" on l-arganine, pycnogenol or l-citrulline.... I am looking for a new doctor and/or Endo in my area that specializes more in these areas. But not easy to find.
(Sorry if everyone is tired of my lengthy posts already! But I have been frustrated for a while and have a lot of questions. And there seems to be a lot of good advice and experience here!)

 

If anything Tadalafil will lower BP but ever so slightly for most men at these dosage levels.

I have a hard time with the supplements causing it from my perspective.

Try eliminating the Tadalafil for a few days and see what happens...then add it back in and evaluate.

NO in the blood stream is normal and healthy and doesn't cause side effects at these levels that I am aware of.

 

Tinman, try Defymed. Just go to their site and navigate. I'm from Puerto Rico and they attend me by e-mail and cel. Very professional and responsible.

 

Hi Gene!.......I have been taking the Tadalafil for a little over a month (usually just 2.5mg daily) with very good success in the bedroom. I was just hoping to get an extra "boost" there as well as the high blood pressure, workout and over all health benefits that I have read about SO many times with l-arganine, Pycogenol and l-citrulline......maybe I should split the dosage into two smaller ones spread out during the day for a while? Maybe 5g/day was just too much for my body?.....what more can anyone tell me about Doxazosin?

If you can split the 2.5 mg pill into two; try taking one before bed and the other half 12 hours later both along with the amino acid stack.

2.5 mg is such a tiny dose, but who knows, you may be an over-responder.