Gene's Nitric Oxide Stack

Many have used this stack for massive hard pumps in the gym, significant vascularity and excellent erectile function not discounting the health benefits. If you're looking for any of these benefits and more...give it a try!

Nitric Oxide Stack
Bed Time
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)


Morning
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)

Afternoon
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)

More Than a Muscle Pump: The Surprising Science of the Nitric Oxide Stack​

In the biohacking world, we often chase complex peptides or experimental compounds, but we frequently overlook the most fundamental currency of life: blood flow. In the quest for longevity, systemic vascular efficiency is the baseline upon which all other health markers are built. As we age, our ability to maintain vasodilatory capacity diminishes, impacting everything from cognitive sharpness to metabolic health. "Gene’s Nitric Oxide Stack," a protocol born and refined within the ExcelMale community, has emerged as a definitive solution for men seeking to optimize this system. This isn't just a gym supplement routine; it is a sophisticated approach to anti-aging that leverages amino acids and targeted pharmaceutical interventions to restore the body’s most vital delivery mechanism.

Beyond the Mirror: The Science of the Sustained Pump​

For the average gym-goer, the "pump" is a transient aesthetic goal—a fleeting moment of muscle fullness. However, for a longevity specialist, a "harder pump" and increased vascularity are indicators of high-functioning endothelial health. The Nitric Oxide Stack is engineered to produce a state of vasodilation that doesn't simply vanish when you rack the weights.

By optimizing the nitric oxide signaling pathway, this protocol facilitates a sustained pump that carries through your daily life. This is a critical distinction: the visual vascularity is a proxy for your body’s ability to keep its "pipes" open. When you maintain that fullness hours after a workout, you are essentially providing proof of concept that your circulatory system is operating at peak efficiency, ensuring constant nutrient delivery to peripheral tissues.

The Foundation of Performance: Hard Science for Sexual Vitality​

One of the most immediate benefits of systemic vasodilation is the restoration of sexual function. From a clinical perspective, erection quality is often the "canary in the coal mine" for cardiovascular health. Because the Nitric Oxide Stack focuses on the root physiological requirements of performance—blood flow and retention—it provides a robust alternative to temporary fixes.

A Serious Solution for Erection Quality and Duration

This stack addresses both the quality and the duration of erections with clinical precision. For men navigating the aging process, this is not a matter of vanity, but of maintaining vital physiological function. By ensuring the vascular system can respond effectively to neurological signals, the protocol allows for a level of performance that many mistakenly believe is lost to time.

The Ultimate Nootropic: Future-Proofing the Neocortex​

Perhaps the most compelling argument for nitric oxide optimization is the "bodybuilder to brain health" pipeline. While most men start this stack for its physical benefits, they are unknowingly deploying a powerful shield against age-related cognitive decline. As we age, the micro-vasculature within the brain tends to narrow and tighten, a process that starves the brain of oxygen and is a primary driver of age-related dementia.

The stack acts as a nootropic by ensuring that the brain's smallest vessels remain dilated and resilient. This ensures that the neocortex and other critical regions receive a constant supply of the nutrients required for cognitive longevity. As the source material highlights:

"by increasing nitric oxide and getting that vascular dilation we're getting oxygen blood and nutrients in the areas of the brain that can provide us with a great anti-aging benefit in terms of neurological health."

The irony is profound: a protocol often associated with the bicep curl may actually be one of your most effective tools for protecting your mind.

Systemic Management: Blood Pressure and Prostate Function​

The benefits of the stack extend into the deeper mechanics of men’s health, specifically regarding the relaxation of smooth muscle tissue. This is particularly relevant for Benign Prostate Hyperplasia (BPH) and blood pressure management. Nitric oxide serves as a signal for these tissues to relax, directly easing the "inability to ease the problems" that typically characterize age-related prostate issues.

The secondary physiological advantages of this systemic relaxation include:

• Vascular Tension Reduction: Significant support for maintaining healthy blood pressure levels by reducing resistance within the arterial walls.
• Prostate Relief: Improvement in quality of life by relaxing the prostatic smooth muscle, easing the mechanical symptoms of BPH.
• Reduced Cardiac Load: By improving systemic flow, the heart is not required to pump against the same level of resistance, preserving cardiovascular longevity.

The Future of Your Vascular Health​

"Gene’s Nitric Oxide Stack" is far from a theoretical exercise; it is a "living protocol" backed by years of community peer-review within the ExcelMale community. The "enormously long" and widely viewed thread on ExcelMale.com serves as a testament to the real-world efficacy of this stack, offering a repository of shared experiences and optimization strategies.

This multi-front approach to anti-aging represents the best of biohacking: using fundamental biological pathways to solve complex aging problems. By focusing on the delivery system itself, we can protect our brains, our hearts, and our vitality simultaneously.

If blood flow is the delivery system for every nutrient your body needs, what happens to your longevity when you finally optimize that system?


More on Nitric Oxide in Men:

Nitric Oxide Pages

 

Thanks for the info Gene.

It's a great stack John and it has worked well for so many men.

The health benefits abound and if you like that hard vascular look with pumps that seem to last forever you'll never give this up.

There are other NO compounds you can try adding in later if you like; I've added Pycnogenol from time to time and seems to enhance the stack as well.

 

I leave for a few days and this thread is 4 pages deep! Way to go, Gene! Great thread.

 

I leave for a few days and this thread is 4 pages deep! Way to go, Gene! Great thread.

Thanks man, and chime in...you ARE the supplement expert!!!

 

Gene, what about Yohimbine? Seems to be a lot written about this in conjunction with Doxazosin.

 

Secure tabs have Tadalafil 5mg. at .99cents!!!!!!!!

 

i was wondering if anyone had the chance to try "tri amino"?

it is said to promote NO and also improve kidney function.

Defy Medical and other offer the product.

 

Gene, what about Yohimbine? Seems to be a lot written about this in conjunction with Doxazosin.

It works in concert with the PDE5i/NO mix...BUT...it has nasty side effect for many men, me included!

I took it and I now know what it feels like to have a massive panic attack...it hit my CNS hard...never again.

For me, I wouldn't touch this stuff with a ten foot poll it was so bad no matter what it did for my libido or my erection quality!

http://en.wikipedia.org/wiki/Yohimbine

Note the caution notice here:
http://examine.com/supplements/Yohimbine/

 

i was wondering if anyone had the chance to try "tri amino"?

it is said to promote NO and also improve kidney function.

Defy Medical and other offer the product.

I tired it numerous times and I still have injection sites till this day that are sore with large inflammatory lumps SQ that seem will never go away.

For me, I won't inject myself with that shit ever again!

 

WOW!!! thanks for the advice...
what about l-citrulline, l-arginine etc improving kidney function? is there any data on this?

Thanks Gene

 

WOW!!! thanks for the advice...
what about l-citrulline, l-arginine etc improving kidney function? is there any data on this?

Thanks Gene

http://examine.com/supplements/Citrulline/
http://examine.com/supplements/Arginine/




GO TO PAGE 2 OF THIS THREAD BY CLICKING ON THE NUMBER TWO BELOW (BOTTOM RIGHT HAND CORNER)

 

http://examine.com/supplements/Citrulline/
http://examine.com/supplements/Arginine/

Love those two compounds. 5+ grams of arginine before bed was studied and improves resting growth hormone secretion.

 

Love those two compounds. 5+ grams of arginine before bed was studied and improves resting growth hormone secretion.

Add the 5 mg of Tadalafil twice daily and it's a freaking powerhouse.

For guys who don't wake with morning erections; it's a sure bet with this stack!

 

Add the 5 mg of Tadalafil twice daily and it's a freaking powerhouse.

For guys who don't wake with morning erections; it's a sure bet with this stack!

Oh.. you know that 5mg twice daily Tadalafil is a staple for me!

 

I know this stack is being suggested for vasodilation and erection quality. However, for those presuming that this will enhance their workouts, is there any evidence that a better pump leads to more strength or muscle gains? I hear the jury is still out on that issue...

 

I know this stack is being suggested for vasodilation and erection quality. However, for those presuming that this will enhance their workouts, is there any evidence that a better pump leads to more strength or muscle gains? I hear the jury is still out on that issue...

From a pure research perspective, there's hasn't been much research on it, Paco. Of course there are a lot of good supporting articles on these amino acids that point to their benefits.

But remember, the foundation of my stack is the PDE5i Tadalafil and alpha blocker Doxazsin; these are two powerhouses.

Everything else is just supplemental and supporting.

Good article with good footnotes: http://www.smart-publications.com/a...ne-this-one-two-amino-acid-punch-can-improve-

See the pdf attached.

Curr Opin Clin Nutr Metab Care. 2007 Jan;10(1):46-51.
Effects of L-arginine supplementation on exercise metabolism.McConell GK.
[h=3]Source[/b]Department of Physiology, The University of Melbourne, Parkville, Victoria, Australia. [email protected]

[h=3]Abstract[/b][h=4]PURPOSE OF REVIEW:[/b]To describe the influence of acute and chronic administration of L-arginine on metabolism at rest and during exercise.
[h=4]RECENT FINDINGS:[/b]There has been substantial examination of the effect of infusion and ingestion of L-arginine at rest. It has been clearly demonstrated that L-arginine administration improves endothelial function in various disease states. In addition, L-arginine infusion at rest increases plasma insulin, growth hormone, glucagon, catecholamines and prolactin. Such hormonal changes affect metabolism. There has, however, been very little examination of the effect of increases in L-arginine availability during exercise. This is important to study as there is preliminary evidence that L-arginine infusion, probably via increases in nitric oxide (NO), alters skeletal-muscle metabolism during exercise. There is a need for further research, especially to understand the mechanisms of how L-arginine affects exercise metabolism and also to determine whether the hormonal responses that occur in response to L-arginine at rest are also present to some extent during exercise.
[h=4]SUMMARY:[/b]This line of research may have important therapeutic implications as there are indications that L-arginine augments the effects of exercise training on insulin sensitivity and capillary growth in muscles.


PMID: 17143054 [PubMed - indexed for MEDLINE]


View attachment Seminario 9 aa-Bq2007.pdf

 

Muscle cell endurance is elevated in the presence of high NO levels. Arginine when taken before bed, will induce resting GH release as well.

 

Muscle cell endurance is elevated in the presence of high NO levels. Arginine when taken before bed, will induce resting GH release as well.

And any IGF-1 panel will prove that out.

I am 3x over the reference range for IGF-1 and I believe this is in part due to the amino stack I take before bed and that includes Arginine and Citrulline as well.

 

And any IGF-1 panel will prove that out.

I am 3x over the reference range for IGF-1 and I believe this is in part due to the amino stack I take before bed and that includes Arginine and Citrulline as well.

I think you and I can supply a small country with some NO.

 

I think you and I can supply a small country with some NO.

Go to bed will yea!

LOL

 

Sometimes the most important factor is not whether it will work or not, but rather if patients will be compliant. With the exception of those whom are very serious, I highly doubt most people will be willing to consume 16 supplements/day, in addition to their TRT regime. Gene's vascularity is impressive; however, if he was not lean, no amount of drugs or supplements would give him that level of vascularity. His supplement program may enhance his vascularity, but is not the predominant reason for it. Congratulations on having the drive and desire to follow such a cumbersome program. Finally, I realize my response may appear to have a negative tone, but in no way is it intended as such.