Enclomiphene on TRT for Fertility

[jc2c]

I think I saw a video a while back with @Nelson Vergel saying some men use Enclomiphene while on TRT and some inexplicably become fertile using that method. What are the cons of trying that? If I wanted to throw that Hail Mary, what dose of Enclomiphene should I use?

 

[Cataceous]

Assuming secondary hypogonadism, then with few exceptions enclomiphene will not restore or maintain fertility with any form of TRT that keeps serum testosterone at mid to high levels continuously. These forms of TRT include injections of testosterone esters, topical testosterone products and pellets. It has been demonstrated by Maximus that at least one form of oral testosterone is short-acting enough to be amenable to stimulation by enclomiphene.

The reason why enclomiphene is usually ineffective with TRT is because there is independent negative feedback by androgens at the hypothalamus. A SERM such as enclomiphene only blocks negative feedback from estrogens.

If you want to try it anyway then you might be interested in my speculation about cistanche, which perhaps would ameliorate the negative feedback by androgens.

The cons are primarily the hassle and expense. There's also uncertainty about the long-term effects of SERM/SARM use. It's not clear how selective these are for the target receptors in the HPTA. There's at least suspicion that enclomiphene can dampen libido via effects on other brain areas.