ED/low libido even with TRT

42HRT

Member
I have been on 110mg a week of test cyp
and add 1500iu for HCG a week split in two doses for both.

I still have low libido/desire.
Last readings had be at total T of 770 at trough and E2 at 51.
I believe it may be more of a sensitivity issues than anything.
As I have noticed when I take THC gummies sensitivity and libido increases.
So its not a physical issue getting hard. More of getting to that point.
I also notice a numbness when I do orgasm since TRT.

Anybody else had this and found a solution?
 
What you are describing is more common than you might think. A few things come to mind that may help. For one, that is a very large dose of HCG. You would be better off to break it into 3-4 weekly doses of 250-300 IU's.

You didn't mention your age.

Have your prolactin levels checked, elevated prolactin can cause those symptoms. If they are high, schedule an appointment with your doctor to explore the possible cause.

Are you on any depression meds? Make a list of all of your medications and supplements and do research on side effects.

It sounds like a possible neurotransmitter issue. Here are some easily to source things to try:

1. 500 mg of L Tyrosine taken with B6
2. Yohimbine HCL
3. Mucuna Pruriens (after you get your prolactin checked, not before)
4. Bacopa

Your E2 seems high, but you didn't provide the type of test and the testing method so that's just a guess. Elevated E2 can cause those symptoms as well.

This is just a start. You need to provide a bit more info.
 
What you are describing is more common than you might think. A few things come to mind that may help. For one, that is a very large dose of HCG. You would be better off to break it into 3-4 weekly doses of 250-300 IU's.

You didn't mention your age.

Have your prolactin levels checked, elevated prolactin can cause those symptoms. If they are high, schedule an appointment with your doctor to explore the possible cause.

Are you on any depression meds? Make a list of all of your medications and supplements and do research on side effects.

It sounds like a possible neurotransmitter issue. Here are some easily to source things to try:

1. 500 mg of L Tyrosine taken with B6
2. Yohimbine HCL
3. Mucuna Pruriens (after you get your prolactin checked, not before)
4. Bacopa

Your E2 seems high, but you didn't provide the type of test and the testing method so that's just a guess. Elevated E2 can cause those symptoms as well.

This is just a start. You need to provide a bit more info.
I’m 44.
My prolactin was checked prior to trt and it was 8. Lower middle of range.
I might try to lower hcg. But that’s likely not the cause as I had this going on before hcg
No depression meds.
The test was estridol and yes it’s higher than pre trt. Which was in the 20s.
I just took another estrogen test today. Will post results.
Thanks for the supplement advice
 

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TRT Hormone Predictor

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⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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