ED/low libido even with TRT

42HRT

Member
I have been on 110mg a week of test cyp
and add 1500iu for HCG a week split in two doses for both.

I still have low libido/desire.
Last readings had be at total T of 770 at trough and E2 at 51.
I believe it may be more of a sensitivity issues than anything.
As I have noticed when I take THC gummies sensitivity and libido increases.
So its not a physical issue getting hard. More of getting to that point.
I also notice a numbness when I do orgasm since TRT.

Anybody else had this and found a solution?
 
What you are describing is more common than you might think. A few things come to mind that may help. For one, that is a very large dose of HCG. You would be better off to break it into 3-4 weekly doses of 250-300 IU's.

You didn't mention your age.

Have your prolactin levels checked, elevated prolactin can cause those symptoms. If they are high, schedule an appointment with your doctor to explore the possible cause.

Are you on any depression meds? Make a list of all of your medications and supplements and do research on side effects.

It sounds like a possible neurotransmitter issue. Here are some easily to source things to try:

1. 500 mg of L Tyrosine taken with B6
2. Yohimbine HCL
3. Mucuna Pruriens (after you get your prolactin checked, not before)
4. Bacopa

Your E2 seems high, but you didn't provide the type of test and the testing method so that's just a guess. Elevated E2 can cause those symptoms as well.

This is just a start. You need to provide a bit more info.
 
What you are describing is more common than you might think. A few things come to mind that may help. For one, that is a very large dose of HCG. You would be better off to break it into 3-4 weekly doses of 250-300 IU's.

You didn't mention your age.

Have your prolactin levels checked, elevated prolactin can cause those symptoms. If they are high, schedule an appointment with your doctor to explore the possible cause.

Are you on any depression meds? Make a list of all of your medications and supplements and do research on side effects.

It sounds like a possible neurotransmitter issue. Here are some easily to source things to try:

1. 500 mg of L Tyrosine taken with B6
2. Yohimbine HCL
3. Mucuna Pruriens (after you get your prolactin checked, not before)
4. Bacopa

Your E2 seems high, but you didn't provide the type of test and the testing method so that's just a guess. Elevated E2 can cause those symptoms as well.

This is just a start. You need to provide a bit more info.
I’m 44.
My prolactin was checked prior to trt and it was 8. Lower middle of range.
I might try to lower hcg. But that’s likely not the cause as I had this going on before hcg
No depression meds.
The test was estridol and yes it’s higher than pre trt. Which was in the 20s.
I just took another estrogen test today. Will post results.
Thanks for the supplement advice
 
I had another estrogen/estriol test.
it was 49.7 pg/ml
High, but probably not high enough to cause ED considering total T is 770 at trough
@BadassBlues Per your advice. I started 500 mg L Tyrosine per day taken on empty stomach in morning. What is the theory of adding B6? And how much B6?
Thank you
 
I had another estrogen/estriol test.
it was 49.7 pg/ml
High, but probably not high enough to cause ED considering total T is 770 at trough
@BadassBlues Per your advice. I started 500 mg L Tyrosine per day taken on empty stomach in morning. What is the theory of adding B6? And how much B6?
Thank you
The active form of B6 is P-5-P:


Role as a coenzyme​

PLP acts as a coenzyme in all transamination reactions, and in certain decarboxylation, deamination, and racemization reactions of amino acids.<a href="Pyridoxal phosphate - Wikipedia"><span>[</span>6<span>]</span></a> The aldehyde group of PLP forms a Schiff-base linkage (internal aldimine) with the ε-amino group of a specific lysine group of the aminotransferase enzyme. The α-amino group of the amino acid substrate displaces the ε-amino group of the active-site lysine residue in a process known as transaldimination. The resulting external aldimine can lose a proton, carbon dioxide, or an amino acid sidechain to become a quinonoid intermediate, which in turn can act as a nucleophile in several reaction pathways.

In transamination, after deprotonation the quinonoid intermediate accepts a proton at a different position to become a ketimine. The resulting ketimine is hydrolysed so that the amino group remains on the complex.<a href="Pyridoxal phosphate - Wikipedia"><span>[</span>7<span>]</span></a> In addition, PLP is used by aminotransferases (or transaminases) that act upon unusual sugars such as perosamine and desosamine.<a href="Pyridoxal phosphate - Wikipedia"><span>[</span>8<span>]</span></a> In these reactions, the PLP reacts with glutamate, which transfers its alpha-amino group to PLP to make pyridoxamine phosphate (PMP). PMP then transfers its nitrogen to the sugar, making an amino sugar.

PLP is also involved in various beta-elimination reactions such as the reactions carried out by serine dehydratase and GDP-4-keto-6-deoxymannose-3-dehydratase (ColD).<a href="Pyridoxal phosphate - Wikipedia"><span>[</span>8<span>]</span></a>

It is also active in the condensation reaction in heme synthesis.

PLP plays a role in the conversion of levodopa into dopamine, facilitates the conversion of the excitatory neurotransmitter glutamate to the inhibitory neurotransmitter GABA, and allows SAM to be decarboxylated to form propylamine, which is a precursor to polyamines.

Effects on Prolactin

Once vitamin B6 is converted to P-5-P, it increases dopamine in the brain. The rise in dopamine lowers prolactin [43].

Bodybuilders report benefits from P-5-P during or after cycles. Anecdotally, it helps prevent gynecomastia (abnormal breast growth) by lowering prolactin levels. Some prefer it over taking L-DOPA.

One pilot study suggests they might be right. In six healthy people, vitamin B6 infusions before exercise increased growth hormone levels and decreased prolactin levels, compared with placebo.


Try 250 MG of P-5-P and 500 MG of L-Tyrosine. Avoid other stimulants while taking this as it may exacerbate the effects. This really helps with orgasm intensity.
 

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Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

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Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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