madman
Super Moderator
Nelson's house u heard it here first!
Dr. Shalender Bhasin!
* over the past 4 decades he has become a global leader in the biology of androgens, sarcopenia and aging related functional decline, his research has shaped clinical guidelines, its informed public health policy particularly around testosterone therapy, anabolic interventions and then the development of function promoting therapies
25:40-34:36
Methods for Assessing Free Testosterone (FT) Levels
Implications of the Inter-monomeric Allostery and Dynamic Changes in Binding Affinity of SHBG and Albumin
Huge contribution to the field and has been working behind the scenes with the CDC on a standardized ED procedure/assay and harmonized reference range for free testosterone!
As of now there is no commercially available standardized ED procedure/asay or a harmonized reference range for FT!
Been waiting on this for years, looking forward to putting an end to this free T s**t show!
Pay attention to 25:40-34:36 of the presentation where he explains the importance of measuring free testosterone using a standardized Equilibrium Dialysis method!
This is what is coming!
Remember what I have been stressing over the years that not all ED devices/procedures are the same!
Interesting that he is still pushing the ensemble allosteric model (EAM) according to Zakharov (cFT-Z) the calculated Tru-T algorithm.
I will be waiting on the new data/validation before jumping the gun here!
This is where it stands as of now!
Bhasin and his team are still active with Phase IIB: Development of TruT Algorithm for Commercializations in Androgen Disorders!
Project end date: 31-August-2026
My reply:
Even then Quest''s ED assay is not the same as the ED assay used in the Jasuja/Bhasin paper that I posted back in 2022 before it was released.
The reference ranges given in that paper only apply to that specific assay (ED device/procedure).
The reference ranges in that paper are not set in stone!
As of now there is no standardized ED procedure/assay or harmonized reference range for free testosterone!
Also need to understand that when it comes to the confusion of the currently used/relied upon ED methods between laboratories for testing free testosterone everyone needs to keep in mind that not all ED devices/procedures are the same.
Dr. Shalender Bhasin!
* over the past 4 decades he has become a global leader in the biology of androgens, sarcopenia and aging related functional decline, his research has shaped clinical guidelines, its informed public health policy particularly around testosterone therapy, anabolic interventions and then the development of function promoting therapies
25:40-34:36
Methods for Assessing Free Testosterone (FT) Levels
Implications of the Inter-monomeric Allostery and Dynamic Changes in Binding Affinity of SHBG and Albumin
Huge contribution to the field and has been working behind the scenes with the CDC on a standardized ED procedure/assay and harmonized reference range for free testosterone!
As of now there is no commercially available standardized ED procedure/asay or a harmonized reference range for FT!
Been waiting on this for years, looking forward to putting an end to this free T s**t show!
Pay attention to 25:40-34:36 of the presentation where he explains the importance of measuring free testosterone using a standardized Equilibrium Dialysis method!
This is what is coming!
Remember what I have been stressing over the years that not all ED devices/procedures are the same!
Interesting that he is still pushing the ensemble allosteric model (EAM) according to Zakharov (cFT-Z) the calculated Tru-T algorithm.
I will be waiting on the new data/validation before jumping the gun here!
This is where it stands as of now!
Bhasin and his team are still active with Phase IIB: Development of TruT Algorithm for Commercializations in Androgen Disorders!
Project end date: 31-August-2026
Where it stands as of now.
Summed up here!
Dr. Bhasin and Dr. Jasuja Xyone therapeutics 2025!
reporter.nih.gov
ABSTRACT
Background
Measurement of free testosterone (T) concentrations is indicated in the diagnosis of androgen disorders, including hypogonadism in men; hirsutism, polycystic ovary syndrome (PCOS), and androgenic alopecia in women; pubertal disorders in boys and management of gender affirming hormone therapies for transgender and gender diverse (TGD) persons. This Phase IIB proposal...
Summed up here!
Dr. Bhasin and Dr. Jasuja Xyone therapeutics 2025!
RePORT 〉 RePORTER
ABSTRACT
Background
Measurement of free testosterone (T) concentrations is indicated in the diagnosis of androgen disorders, including hypogonadism in men; hirsutism, polycystic ovary syndrome (PCOS), and androgenic alopecia in women; pubertal disorders in boys and management of gender affirming hormone therapies for transgender and gender diverse (TGD) persons. This Phase IIB proposal...
My reply:
Even then Quest''s ED assay is not the same as the ED assay used in the Jasuja/Bhasin paper that I posted back in 2022 before it was released.
The reference ranges given in that paper only apply to that specific assay (ED device/procedure).
The reference ranges in that paper are not set in stone!
As of now there is no standardized ED procedure/assay or harmonized reference range for free testosterone!
Also need to understand that when it comes to the confusion of the currently used/relied upon ED methods between laboratories for testing free testosterone everyone needs to keep in mind that not all ED devices/procedures are the same.
