Does Testosterone Make COVID-19 Worse?

[pyater]

Interested to see thoughts here. I am still wondering about the high prevalence of COVID-19 in males. What is it? Lifestyle choices - smoking, alcohol use, the likelihood of other comorbidities, like high blood pressure, diabetes, obesity?

Commentary: Testosterone, a key hormone in the context of COVID-19 pandemic - PMC

www.ncbi.nlm.nih.gov

Do you think TRT helps because of the prevalence in older males which are likely lower T. Not seen in high prevalence in teenage boys? Or does it raise the risk because of this TMPRSS2? I would love to see this studied or data gathered via EMR.

Welcome, the discussion here.

 

[DS3]

Interested to see thoughts here. I am still wondering about the high prevalence of COVID-19 in males. What is it? Lifestyle choices - smoking, alcohol use, the likelihood of other comorbidities, like high blood pressure, diabetes, obesity?

Commentary: Testosterone, a key hormone in the context of COVID-19 pandemic - PMC

www.ncbi.nlm.nih.gov

Do you think TRT helps because of the prevalence in older males which are likely lower T. Not seen in high prevalence in teenage boys? Or does it raise the risk because of this TMPRSS2? I would love to see this studied or data gathered via EMR.

Welcome, the discussion here.

This already has a thread. Search it.

 

[pyater]

Ok. Searched it twice and Still can’t find it

 

[DS3]

Why the Coronavirus Seems to Hit Men Harder Than Women...Estrogen Levels?

Maybe one more reason to let your Estrogen levels rise when doing TRT. Although men and women have been infected in roughly equal numbers, researchers found, the death rate among men was 2.8 %, compared with 1.7% among women.... could Estrogen levels be the key to the difference? Link To...

www.excelmale.com

 

[DS3]

COVID-19 - Anyone stopping TRT as a precaution?

Just curious to the group. Anyone stopping TRT out of an abundance of caution? Higher rate of male deaths? Curious as to what others are doing with this protocol?

www.excelmale.com

 

[Wilson7]

Changing nothing unless there is sound evidence to show otherwise, your T would plummet. It would be nice if they looked at older men in NYC on HRT vs not on HRT, and mobidity and mortality from COVID vs treated men with estrogen to see if it helps because that shuts down endogenous T, so what is it, higher E or lower T or both? It's not that simple IMO, men = testosterone and women = estrogen = disease outcome. In fact, testosterone is the dominant sex steroid circulating in women. Median E2 in women 100 pg/ml, median T in women 400 pg/ml. The ratio is important as well. Only thing I'd change if I were still on it would be an aromatase inhibitor, I'd cut it out unless I had Sx of estrogen excess, not I think I do, but actual gyno for example.

 

[Nelson Vergel]

Low T a Risk Factor for Covid-19

A study evaluated the risk factors of men admitted to a hospital in Germany for Covid-19 and found that one factor is low testosterone levels. This run contrary to recent discussion in the media where it has been argued that testosterone raises the risk for Covid-19. The preprint is on MedRxiv...

www.excelmale.com

 

[Nelson Vergel]

Covid-19 and the Testes

This preprint explores the effects of Covid-19 on sexual hormone levels in men. The study finds that LH levels are elevated, FSH and testosterone levels are the same. And they hypothesize that Covid-19 impairs testosterone production, so the body boosts LH levels to compensate, bringing...

www.excelmale.com

 

[Nelson Vergel]

Coronavirus Affects More Men Than Women - Potential Reasons

Table of Contents The coronavirus pandemic has taken everyone by surprise in the latest weeks as no one expected that a virus similar to influenza can spread so quickly and infect thousands of people worldwide. At March 16, 2020, there are nearly 190,000 confirmed cases of coronavirus...

www.excelmale.com

 

[Nelson Vergel]

VA researchers start clinical trials on prostate cancer drug degarelix as possible coronavirus treatment

VA researchers have enrolled 200 veterans in a trial testing whether the prostate cancer drug degarelix could prove to be an effective treatment for men with COVID-19.

www.newsweek.com

 

[Nelson Vergel]

Screening for low testosterone is needed for early identification and treatment of men at high risk of mortality from Covid-19 - Critical Care

ccforum.biomedcentral.com

 

[Nelson Vergel]

Screening for low testosterone is needed for early identification and treatment of men at high risk of mortality from Covid-19 - Critical Care

ccforum.biomedcentral.com

 

[fifty]

“ A repeated observation that disease severity and mortality rate of Covid-19 is significantly higher in male rather than female sufferers has led researchers to investigate the role of sex hormones in disease progression.”

So based on this they investigated and found that LowT increased disease severity despite them expecting the opposite result?

 

[Nelson Vergel]

Pretty good guide to save in case that anyone you know needs help The pharmacist’s guide to treating COVID-19 symptoms with OTC drugs

 

[Nelson Vergel]

The US Food and Drug Administration (FDA) issued an emergency use authorization for the first at-home COVID-19 diagnostic test, which provides results in 30 minutes or less.

The COVID-19 prescription All-In-One Test Kit (Lucira Health) is a molecular, single-use test that detects SARS-CoV-2 using self-collected nasal swab samples in people aged 14 years and older who are suspected of having COVID-19 by their healthcare provider.

In a community sample, in which the test was compared with an FDA-approved, high-sensitivity SARS-CoV-2 test, the Lucira test achieved a 94% positive percent agreement and a 98% negative percent agreement. After exclusion of samples with very low levels of virus that possibly no longer reflected active infection, Lucira's test achieved 100% positive percent agreement, according to the company's website.

FDA Clears First Rapid At-Home COVID Test

Lucira Health’s prescription COVID-19 All-In-One Test Kit can be performed entirely at home — or in point-of-care settings — with results in 30 minutes or less.

www.medscape.com

 

[Nelson Vergel]

New Study: Better Fitness Can Reduce COVID-19 Severity

Aerobic fitness plays a key role in coronavirus defense and lower risk of hospitalization, according to recent research.

thesource.lifetime.life

 

[Wilson7]

Thus far I've known a number of older men and women at the gym that are on HRT (T) and have had COVID. All mild cases with full recovery in 2 - 4 weeks, myself included.

 

[Nelson Vergel]

Blocking testosterone did not help

A Phase 2 Trial of the Effect of Antiandrogen Therapy on COVID-19 Outcome: No Evidence of Benefit, Supported by Epidemiology and In Vitro Data - PubMed

We studied whether inhibition of testosterone could diminish COVID-19 symptoms. We found no evidence of an effect in a clinical study or in epidemiological or experimental investigations. We conclude that androgen inhibition should not be used for prevention or treatment of COVID-19.

pubmed.ncbi.nlm.nih.gov

 

[Vince]

It seems or what I have read. If you have blood type o, you're better at fighting off covid-19. If you're a APO-E 4 you will struggle with fighting off covid-19.

 

[Vince]

APOE ε4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue: a Finnish biobank, autopsy and clinical study - Acta Neuropathologica Communications

Apolipoprotein E ε4 allele (APOE4) has been shown to associate with increased susceptibility to SARS-CoV-2 infection and COVID-19 mortality in some previous genetic studies, but information on the role of APOE4 on the underlying pathology and parallel clinical manifestations is scarce. Here we...

actaneurocomms.biomedcentral.com