Crashed Estradiol - How Long to Recover?

I actually did have allergy testing done, and cottonseed came up negative. I also started itching before I injected (was on a Clomid and Anastrozole and DIM coumponded pill before starting TRT). After about a month and a half on that ****tail I started itching. After starting injections my skin erupted into full blown eczema, rash/red/irritated/dry flaky skin. I want to get off everything and see if my body heals, but im pretty sure tossing my hormones around has affected my skin

Again if i just had oily skin/bloat/sensitive nips i would know my E2 is high, but I have low E2 symptoms with high E2 bloods, makes getting dialed in impossible

A very late reply but I have ran to an situation like yours. The guy had both same time, high e2 anf low e2 symptoms at once. Turned out (eventually) that a long term overdoing with anastrozole had f**ked up the total estrogen metabolism.. he had stopped the AI to solve the problem and naturally e2 (estradiol) rebounded and made symptoms, but mean while hid e1 (estrone) wich is the estrogen responsible for fluided joints and skin, remained low. And it also seemed that taking AI will more strongly tank the e1 than it does to e2.
So he ran more labs comparinf differend estrogens. Tried DIM to rebalance them etc..
But the solution after all was to take low-dose HCG with T and stay the hell out of AI eaven dispite of clear e2 symptoms.. its horrible at some point, deffinetly. But in the end things looked good again.
 
I too got itching in my body (mostly stomach and breast area) after most likely crashing my E2 with arimidex for awhile.. Might need to run more estrogen test to see E1 etc.. this is so frustrating.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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