Correct Pregnenolone and Insulin Resistance, then TRT ? (Labs included)

slisto

New Member
Hello All,

Appreciate your time and feedback,

I am a 50 y/o male 5'10, 215 BF% ~15% (exercise 4-5 x/ wk mix of cardio and weights) experiencing classic ADAM test sx over the last 2 years. Trialed on Clomid tried 25 mg daily or 50 mg EOD for several weeks,(brought up my test to low 400's, but felt horrible on it, no libido, moody), also trialed HCG 500 iu 3x a week for several months with similar results.

Recently had lab work done which I will post. The DO I am seeing is big proponent of keto diet. Was told that once I fix my insulin resistance T could go up 250 points...seems a stretch to me. Also told my pregnenelone was low.
Rx'd compounded Pregnenelone 25 mg daily (I went up to 50 mg, but had insomnia and some irritability), taking 25 mg of DHEA on my own as well as well as turmeric, liver sup, krill oil, berberine, ALA, some agmatine, and the occasional Cialis, OTT I am on no other rx'd meds at this time. I do have moderate central and obstructive sleep apnea and failed trials on several different masks.

Am going to ask to start on TRT at next visit as I am still having zero morning wood, and no libido, low energy and motivation. Asking to start at 50 mg test cypionate 2x a week with no AI or HCG.

Any thoughts, lab analysis, and/or suggestions are appreciated. Thank you very much!
 

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Why is your estradiol so high? The preg/dhea?
That was before the preg and dhea! I talked it over with the DO and mentioned that the test he ordered vs the sensitive assay for men ((LC-MS)) was the reason that the estradiol was higher than prob would have been shown on the sensitive test, but I suspect it is high anyway, and he agreed with me. So I asked myself then why order the outdated test, doh!!
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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