Cipionate vs Natesto

Smokin Joe

Active Member
I was wondering about switching to Natesto from Cipionate as I just found it was on the insurance formulary.
Looking for more out of trt.
Has anyone had better results from switching to Natesto?
 
Though not exactly what you're asking, @Willyt has a nice writeup on his experience with Natesto:
@stx359 describes his experience, but he was on hCG at the time, which prevented HPTA activation:
@Fortunate has a good thread here:
 
I was wondering about switching to Natesto from Cipionate as I just found it was on the insurance formulary.
Looking for more out of trt.
Has anyone had better results from switching to Natesto?

If anything I would think that you will find more men who have tried Natesto only and even then it would be far from common.

Most men on trt use injections or transdermal (gel/cream).

I would not put too much weight on a handful of experiences as some of these same individuals are not applying Natesto 2-3 times daily which would be needed when used as a monotherapy.

Even then the only way you will know is to give it a go!

It may very well turn out to be worth your time.
 
My overall experience has been positive. It’s inconvenient, but it’s less likely to cause problems than other forms of TRT. Anecdotally, I have heard of some people alleviating depression by using Natesto alone.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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