Thanks for all the replies. I have a very difficult case. I recently came completely off everything after 8 years, but unfortunately had no pituitary response to Clomid. I'm working with my urologist and
Defy to sort this out.
Defy advises me to discontinue clomid and restart TRT. I've started back at 80mg per week 40x2. My problem all along has been absolutely no libido on trt. I have very high shbg, usually 50-70 range. Large doses have never worked. I realize this is common thinking regarding elevated shbg, but has never held true with me.
I feel ok now at 80mg but again have no libido and can't perform without cialis. I spent several years at 100mg per week once e7d. I had no ED at this dose and very little libido. I've tried doses all the way up to 200mg per week but the high doses make me feel terrible. 1
00 mg puts me 850-900ng day seven, 80mg 700-725ng day seven, 120mg 1000-1025ng day 7. All these are once weekly doses. Probably felt the best at
120mg as far as energy but this dose increased hematocrit too much. Defy wants me to do twice weekly dosing and I'm going to give it a try, but I think I'm going to have to raise the dose some. I don't do well with hcg at any dose and can only take dhea at 10mg daily, also cannot tolerate pregnenolone at any dose. I'm hopeful between
Defy and my urologist that we can figure something out. I've never at any dose had any problems with E2, in fact it's normally 20-25 sensitive assay no matter what the dose. I figure I've wasted eight years of my life trying to figure this out so another year to isn't going to hurt anything.