Bringing dhea levels up

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tmckenzie

Member
I think i am going to check my 4x cortisol again, I think I can order it myself. Since taking cortisone makes me cramp, and I am on dhea and preg, how should I bring levels up, if they are still low?
 
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paco

Member
Below is from a presentation that Dr. Neil Rouzier, M.D. did at the National A4M Conference last year. I think he's one of the top minds in anti-aging medicine today. Note his administration (dosing) and his optimal levels for DHEA!

Thanks, Gene. What are your thoughts on how to determine the correct, individualized dose for Pregnenolone?
 
I think i am going to check my 4x cortisol again, I think I can order it myself. Since taking cortisone makes me cramp, and I am on dhea and preg, how should I bring levels up, if they are still low?

When mine were low my doc gave me a supplement called Adren-all and it really helped bring them up. Of course it is herbal with some adrenal extract and other stuff, but it seemed to work well. Not sure if it has stuck over a year later but I should have my 4x cortisol results any day.
 

Gene Devine

Super Moderator
Thanks, Gene. What are your thoughts on how to determine the correct, individualized dose for Pregnenolone?


Good question considering that the Pregnenolone labs are highly unreliable since most of our Pregnenolone resides in tissue and not blood serum.

The 50 mg per day has been the standard recommended dosage by most of the top HRT Physicians including Life Extension and others.

It's been my dose for years and I feel good not worse...I will stick to it.
 

Jeffrey Becker

New Member
I wanted to chime in here and report I started using the Nature's Plus lipoceutical DHEA sublingual spray mentioned in this thread - and feel better with it. There have been no negative issues as I had previously experienced with most forms of oral DHEA I had used in the past.
 
IMO, Pregnenolone is highly overrated and causes way to many side effects for me.... Acne, oily skin and irritability to name a few.

For those of you that take benzo's, pregnenolone antagonizes certain acute effects.....
 

OMI100

Member
Orin, you have my curiosity peaked even higher. If you find a chance to put a thread (or have one) together in the thyroid section, would enjoy hearing about your treatment program, labs, & the meds you're on. NDT or any thyroid medication for that matter is even more of a reason to make sure your cortisol is where it needs to be. I'm waiting on my 4x saliva kit as we type ...

Where to get the saliva kit and cost?
 
The one just used was from vitaliving and was $130 for 4x cortsol plus DHEAs. I think most all the ones out there end up gong to ZRT labs, so just shop by price is my motto!
 

OMI100

Member
I checked LEF.ORG and they offer a Cortisol, 24 Hour urine test Item# LC004432 at $79.00 non-member , $59.00 member price. They also offer an AM blood test and a AM+PM blood test for about the same price. Any input of the benefits of a urine or blood test over the ZRT test?
 
For cortisol the diurnal saliva test is the gold standard. Blood tests only give you a snapshot and 24 hour urine only gives an average. With the saliva you collect a tube at four times and can then plot out your cortisol pattern. Go with the diurnal 4x saliva and it usually also gives you DHEAs results too.
 

OMI100

Member
The one just used was from vitaliving and was $130 for 4x cortsol plus DHEAs. I think most all the ones out there end up gong to ZRT labs, so just shop by price is my motto![/QUOTE


Any one use Canary Club?


Canary Club Diurnal Cortisol 4x

A saliva test designed to measure the levels of the hormone cortisol, taken four times in a 24-hour period (morning, noon, evening, and nighttime). Recommended with situational stress and fatigue; an indicator of adrenal imbalance.


Summary: The Canary Club Diurnal Cortisol Home Saliva Kit tests cortisol levels. Test includes: four samples of cortisol collected through saliva (C1, C2, C3, C4).Price: $119.00
Also known by ZRT Lab Product Name: Diurnal Cortisol

Looks like the best price.

wonder if a new thread just on Cortisol is warrented?
 
If canary club has the best price then use them - almost every single cortisol test I have seen goes to ZRT labs like you posted above. So find the outfit that provides the ZRT lab test at the cheapest price and run with it. 119 is cheaper than the 130 I paid from Vitaliving.
 

OMI100

Member
08-2013

BASE LINE –ONLY 10% COMPOUNDED “T” CREAM

Total “T” –796 – (348 – 1197)
Free “T” –18.5 – (6.6 – 18.1)
DHEA – 10.2– (51.7 – 295)
Estradiol –14.7 – (7.6 – 42.6)
SHBG -- 32.5 – (19.3 – 76.4)

09-2013

With 50mg DHEA compounded cream ad 50 mg compounded Pregnenolone cream

Total “T” –514 – (348 – 1197)
Free “T” –9.7 – (6.6 – 18.1)
DHEA – 35.5– (51.7 – 295)
Estradiol –14.8 – (7.6 – 42.6)
SHBG -- 34.9 – (19.3 – 76.4)

Pregnenolone,MS – 19 – (Less than 151)



10-2013

With 100mg DHEA compounded cream ad 100 mg compounded Pregnenolone cream

Total “T” –798 – (348 – 1197)
Free “T” –17.6 – (6.6 – 18.1)
DHEA – 31.8– (51.7 – 295)
Estradiol –28.5 – (7.6 – 42.6)
SHBG -- 36.5 – (19.3 – 76.4)

11-2013

25mgmicronized DHEA morning and evening and 50 mg micronized Pregnenolone in themorning

Total “T” –822 – (348 – 1197)
Free “T” –14.0 – (6.6 – 18.1)
DHEA – 273.5 – (51.7 – 295)
Estradiol – 33.5– (7.6 – 42.6)
SHBG -- 36 – (19.3 – 76.4)


test labs at the bottom.....

08-2013

Total “T” – 796 – (348 – 1197)
Free “T” – 18.5 – (6.6 – 18.1)

Estradiol – 14.7 – (7.6 – 42.6)
SHBG -- 32.5 – (19.3 –76.4)
Pregnenolone, MS – 19 – (Less than 151)


09-2013
With 50mg compounded cream and 50 mg compounded Pregnenolone cream
Total “T” – 514 – (348 – 1197)
Free “T” – 9.7 – (6.6 – 18.1)
DHEA – 35.5 – (51.7 –295)
Estradiol – 14.8 – (7.6 – 42.6)
SHBG -- 34.9 – (19.3 –76.4)


10-2013
With 100mg DHEA compounded cream and 100 mg compounded Pregnenolone cream
Total “T” – 798 – (348 – 1197)
Free “T” – 17.6 – (6.6 – 18.1)
DHEA – 31.8 – (51.7 –295)
Estradiol – 28.5 – (7.6 – 42.6)
SHBG -- 36.5 – (19.3 –76.4)



11-2013
25mg micronized DHEA morning and evening and 50 mg micronized Pregnenolone in themorning
Total “T” – 822 – (348 – 1197)
Free “T” – 14.0 – (6.6 – 18.1)
DHEA – 273.5 – (51.7–295)
Estradiol – 33.5 – (7.6 – 42.6)
SHBG -- 36 – (19.3 – 76.4)



12-2013
50mg micronized DHEA morning and evening and 50 mg micronized Pregnenolone in themorning
Total “T” – 721 – (348 – 1197)
Free “T” – 15.1 – (6.6 – 18.1)
DHEA – 432.4 – (51.7 –295)
Estradiol – 29.2 – (7.6 – 42.6)
SHBG -- 33.5 – (19.3 – 76.4)

1-22-2014 BLOOD DRAW
100mg micronized DHEA morning and - 50 mg - evening
50 mg micronized Pregnenolone in themorning
Total “T” – 821 – (348 – 1197)
Free “T” – 18.4 – (6.6 – 18.1)
DHEA – 529.4 – (51.7 –295)
Estradiol – 31.9 – (7.6 – 42.6)
SHBG -- 34.7 – (19.3 – 76.4)



HOT OUT OF THE LAB!!!!
2-21-2014 BLOOD DRAW
MRM brand DHEA and Pregnenolone
100mg micronized DHEA morning and - 50 mg - evening 50 mg micronized Pregnenolone in themorning
Total “T” – 691 – (348 – 1197)
Free “T” – 10.8 – (6.6 – 18.1)
DHEA – 441.2– (48.9 – 344.2)
Estradiol – 30.6 – (7.6 – 42.6)
SHBG – 36.8 – (19.3 – 76.4)

Range on the DHEA test changed?
Both "T" and free "T" went down a bit. I have noticed that my compounded cream could be mixed a bit better as there are small lumps from time to time, but over all I am in the 700 to 800 range most test.

I did the Canary cortisol (4 sample) test and wating on results.

Did some additional labs today in preperation of seeing my DR in 2 weeks or so. Will be interesting to see those results.

SHBG seems to be staying in the 34 to 37 range.

E2 seems to be staying in the 30 range at thigh DHEA range.

I will stay at the 150mg DHEA and 50 mg Pregnenolone[/COLOR]
 

Jeffrey Becker

New Member
FWIW I had previously reported in this thread that oral forms of DHEA or pregnenolone I had tried absolutely killed my sex drive. Based on another members feedback here, I tried a product made by Nature's Plus, called Instaceutic DHEA Spray, a sublingual application, with very good results as of my first bottle (better energy, better sex drive, better wood). I recently re-ordered this product, and inexplicably, the company re-formulated the product. After a couple weeks use, once again my sex drive and ability to get an erection (morning wood or otherwise) plummeted. Since I bought three bottles, I intend to return the rest if possible.

I think the next step for me will be to try McPherson Labs as recommended by Gene, and see if that works for me.
 

OMI100

Member
Canary Club Diurnal Cortisol 4x (ZRT) results:
3.6 (3.7 -9.5) Morning
2.1 (1.2 - 3.0) Noon
1.3 (0.6 - 1.0) Evening
0.8 (0.4 - 1.0) Night

So what does all mean?
 

OMI100

Member
Ran some test on 23 April 2014 and the DHEA was waaaay over top.
Had been doing bloodwork and not taking my T cream and thyroid meds, but took my other meds and supplements.
This time I did not take any meds or supplements..
Results for 6 May 2014:
MRM brand DHEA and Pregnenolone
100mg micronized DHEA morning and - 50 mg - evening 50 mg micronized Pregnenolone in themorning
Total “T” – 789 – (348 – 1197)
Free “T” – 19.2 – (6.6 – 18.1)
DHEA – 673.6– (48.9 – 344.2)
Estradiol – 56.1 – (7.6 – 42.6) Standard
Estradiol – 14 – (3 – 70) Sensitive
SHBG – 34.3 – (19.3 – 76.4)
I will reduce my DHEA by 50 mg and that looks like I should get into the sweet spot...
 

Gene Devine

Super Moderator
Ran some test on 23 April 2014 and the DHEA was waaaay over top.
Had been doing bloodwork and not taking my T cream and thyroid meds, but took my other meds and supplements.
This time I did not take any meds or supplements..
Results for 6 May 2014:
MRM brand DHEA and Pregnenolone
100mg micronized DHEA morning and - 50 mg - evening 50 mg micronized Pregnenolone in themorning
Total “T” – 789 – (348 – 1197)
Free “T” – 19.2 – (6.6 – 18.1)
DHEA – 673.6– (48.9 – 344.2)
Estradiol – 56.1 – (7.6 – 42.6) Standard
Estradiol – 14 – (3 – 70) Sensitive

SHBG – 34.3 – (19.3 – 76.4)
I will reduce my DHEA by 50 mg and that looks like I should get into the sweet spot...

One can see that micronized DHEA and Preg is the way to go! I had the same results when I switched from a transdermal DHEA and Preg to micronized slow release pill form...labs went through the roof:)

BTW, look at the difference in lab results for your E2!

See how the Standard default lab over estimates men's E2 levels compared to the Sensitive lab!

If a Doc just ordered the standard lab he might end up prescribing an AI to get your E2 serum levels down when in fact you are probably already too low!

This is why it is so important to order the Sensitive assay...no if ands or buts about it!!!
 

OMI100

Member
23 April 2013 labs when I took supplements in the A.M. and NO T or thyroid meds.
This test had the DHEA waaaaaaaaaaaay over range.
That is why I did (6 May 2014) last blood work with NO meds or supplements in the A.M.
Not sure of thre high T unless I forgot to NOT put it on in the morning?
Testosterone, Serum – 941 - 348-1197
Free Testosterone(Direct) - 27.9 – (6.6-18.1)
DHEA-Sulfate - 855.8 – (30.9-295.6)
Estradiol - 55.9 – (7.6-42.6) (LabCorp 004515)
Estradiol, Sensitive - 15 - (3-70) (LABCORP SENSITIVE #140244
 
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