Natural Pregnenolone production

What has your own research indicated? I haven't heard this before. I think you're interpretation of a shutdown they way you're expressing it isn't quite correct; destroys.
 
I've also wondered this before. For someone not on trt, will taking pregnenolone decrease or even shut down the bodies own production of pregnenolone? I'd be curious as to what effect pregnenolone supplementation has on the body's own production. If you take testosterone, the body shuts down testosterone production. Does pregnenolone work the same way?
 
I've also wondered this before. For someone not on trt, will taking pregnenolone decrease or even shut down the bodies own production of pregnenolone? I'd be curious as to what effect pregnenolone supplementation has on the body's own production. If you take testosterone, the body shuts down testosterone production. Does pregnenolone work the same way?

AFAIK, the down stream hormones signaling hormones (LH and ACTH) stimulate production of pregnenolone.

So trt shuts down LH, which will probably result in less pregnenolone. There's still ACTH stimulating some production from what I know.

It's possible exogenous preg lowers preg levels but I do no think this has been studied. I mean preg isn't even something most on trt check.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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