DHT/estradiol optimal ratio in men

[ak7802]

Hi, what's the optimal ratio of DHT to estradiol and testosterone? Testosterone and estradiol are within the upper limits of normal, while DHT is more than twice the normal range. Could this imbalance be causing erectile dysfunction and libido problems? If so, is it better to increase estradiol above the normal range or lower DHT levels to within the normal range?

 

[SS1LE]

yes longterm higher DHT can create issues for some, usually in the terms of displacing estradiol which in return gives you low E2 symptoms even though estradiol is in good range.

 

[FunkOdyssey]

Hi, what's the optimal ratio of DHT to estradiol and testosterone? Testosterone and estradiol are within the upper limits of normal, while DHT is more than twice the normal range. Could this imbalance be causing erectile dysfunction and libido problems? If so, is it better to increase estradiol above the normal range or lower DHT levels to within the normal range?

What protocol is producing these labs? Scrotal cream?

 

[WhiteMale]

IMHO the notion of a ratio of hormones is utter garbage.

You're not divulging enough to base an opinion off; labs and protocol.

 

[ak7802]

What protocol is producing these labs? Scrotal cream?

No scrotal cream, 35 mg testoterone enan Sub-Q every day, and 10 mg primobolan Sub-Q every day.

 

[ak7802]

yes longterm higher DHT can create issues for some, usually in the terms of displacing estradiol which in return gives you low E2 symptoms even though estradiol is in good range.

So, keeping estradiol higher than normal rage (about 70 pd/ml) might be a solution ?

 

[FunkOdyssey]

No scrotal cream, 35 mg testoterone enan Sub-Q every day, and 10 mg primobolan Sub-Q every day.

You're probably barking up the wrong tree with the ratio here. You're doing at least three things which are commonly associated with poor libido and erectile problems:

1. Daily injections of long esters
2. Use of primobolan at any dose
3. Massive doses of testosterone
4. (Controversial bonus) Subq injections

 

[Nelson Vergel]

T ng/dL x 0.04= E2 in ng/dL x 10= E2 in pg/mL (Estradiol is usually 0.2-0.4% of Total T)

T ng/dL x 0.1= DHT in ng/dL (DHT is near 10% of total T)


DHT/E2= 0.10/0.04= 2.5

 

[ParetoPEDGuy]

No scrotal cream, 35 mg testoterone enan Sub-Q every day, and 10 mg primobolan Sub-Q every day.

You're pulling too many levers at once, which makes this hard to diagnose cleanly.
DHT and E2 need to be in balance for optimal libido and erection quality. Most guys know you can raise E2 via HCG adjustments, less frequent/larger injections, or dropping AI-like ancillaries.

What fewer guys realize is that excessively high DHT acts as an aromatase inhibitor at the tissue level. Your labs can show "normal" E2 while your functional E2 is effectively suppressed. So you have two ways to fix the ratio: raise E2 or lower DHT.

Which is right for you depends entirely on your situation. Personally I had to lower DHT because 5 clicks of scrotal cream had me with bacne, oily skin and scalp pimples worse than puberty at 38. But if those sides weren't present I'd have just titrated HCG up instead, because I'm someone who needs higher E2 for maximum libido.

When I first got on Test Cyp 150mg/week plus 1000 IU HCG/week my E2 hit 61 and guys were telling me to take anastrozole immediately. Meanwhile my libido was absolutely unhinged, my wife was like "I can't do this anymore, this is worse than when you were a 21-year old sex addict, like I'd almost be relieved if you got a mistress at this point." lol

In contrast, some guys feel terrible above a certain E2 threshold regardless of DHT. Those guys need to lower DHT to fix the ratio because raising E2 simply isn't a lever available to them.

Now a few questions about your protocol:

-Why enanthate with daily injections? Long esters like enanthate aromatize less than cypionate even at once-weekly IM dosing, so daily subq with enanthate seems like an odd combination.

-Why primobolan?

-Have you tried testosterone cream? Scrotal application handles DHT reliably without excessive aromatization, and you can then dial in libido on an extremely granular basis purely by titrating HCG until you find your number. Much easier to optimize than managing injections.

 

[Nelson Vergel]

What fewer guys realize is that excessively high DHT acts as an aromatase inhibitor at the tissue level. Your labs can show "normal" E2 while your functional E2 is effectively suppressed. So you have two ways to fix the ratio: raise E2 or lower DHT.

Great comment.

When I first got on Test Cyp 150mg/week plus 1000 IU HCG/week my E2 hit 61 and guys were telling me to take anastrozole immediately. Meanwhile my libido was absolutely unhinged,

I am glad you are reporting this. E2 has been linked with libido, although I wish we had good data on T/E2 ratios and libido.

 

[FunkOdyssey]

Why enanthate with daily injections? Long esters like enanthate aromatize less than cypionate even at once-weekly IM dosing, so daily subq with enanthate seems like an odd combination..

I was with you, right up until this statement. Where did you get the idea that enanthate aromatizes less than cypionate?