My Experience On Jatenzo (Oral TRT) Log

I have my doubts that TRT will ever work for me. I have identified my issues. Testosterone increases iron uptake by inhibiting hepcidin and regulates iron absorption.

When hepcidin is suppressed, more iron is available for the body to use.

This is precisely my problem. I experience high iron symptoms on TRT eating foods with iron in it, and unless I'm on the verge of an iron deficiency, this is the only time feel normal for a brief time after a blood donation, regardless of the TRT dosage.

I also can’t tolerate vitamin D supplementation on TRT. Vitamin D affects iron bioavailability, further exacerbating the issue. I have no problems while off TRT and supplementing vitamin D, as long as it’s kept under 2000 units otherwise I will get symptoms of excess iron.

Maybe a peptide can increase my natural T production. It's only been 5 days since stopping Jatenzo and last night my testicles started arching. My HPTA is strong at coming back online even after 7 years on TRT.

I want to get myself into a fasting state most of the day eating one meal per day in the evening but also working out every day.

Maybe a protein shake with peanut butter in the morning?

Can I do this without causing any harm?
 
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@Systemlord wow dude, I wish I looked like that!! Great job!!!

To summarize your experience… outside of the iron issues, do you think oral T was a good option compared to others? Did it ever affect your liver ir kidney function at all?
 
To summarize your experience… outside of the iron issues, do you think oral T was a good option compared to others?
I got a better response on Jatenzo, definitely has less side effects. My kidney and liver function are strong. I recall the ER doctor once saying my kidneys are very strong.

I never got any fluid retention on TRT at all.

On a sidenote, none of the type two diabetes drugs worked beyond the first dosage. Most of the type two diabetes drugs caused a potassium deficiency on the second dose. The GLP-1 antagonists would only work on the first dose only and never after. Maybe one day I’ll know why.
 
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I got a better response on Jatenzo, definitely has less side effects. My kidney and liver function are strong. I recall the ER doctor once saying my kidneys are very strong.

I never got any fluid retention on TRT at all.

On a sidenote, none of the type two diabetes drugs worked beyond the first dosage. Most of the type two diabetes drugs caused a potassium deficiency on the second dose. The GLP-1 antagonists would only work on the first dose only and never after. Maybe one day I’ll know why.
Are you sure you have type 2? Check out the RADIANT study (ongoing).

I haven’t responded well to diabetes meds either except mounjaro and ozempic, but both exacerbated hypoglycemia.
 
I haven’t responded well to diabetes meds either except mounjaro and ozempic, but both exacerbated hypoglycemia.
Beta blockers can prolong, enhance, or alter the symptoms of hypoglycemia in insulin-dependent diabetics. They can also increase the odds of hypoglycemia in hospitalized patients who are not receiving basal insulin.
 
Are you sure you have type 2? Check out the RADIANT study (ongoing).

I haven’t responded well to diabetes meds either except mounjaro and ozempic, but both exacerbated hypoglycemia.
I filled out the Radiant study questionnaire, and hopefully they will be contacting me soon.

The one question that intrigued me was do I have any nervous system disorders, to which I replied, Tourette’s Syndrome.

This nervous system disorder makes my nervous system highly reactive.
 
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My HPTA recovery log:

This is quite hilarious. I’m rolling around laughing on the floor. A total testosterone at 104 and an SHBG at 31. Talk about a pink elephant in the room.

The testosterone panel below was drawn by mistake and I ended up drawing labs at 3:25 pm!

I would love for some of the experience members on this forum to explain to me how I can have a total testosterone at 104 and have an SHBG of 31. By all accounts, total testosterone should be higher when SHBG is triple what it was when I was diagnosed with type 2 diabetes and yet total testosterone is largely unchanged.

This will be an interesting topic of conversation!

Even more interesting is my calculated free testosterone is lower than when my diabetes was out of control 7 years ago. Hopefully in the years to come we'll found out if SHBG exerts some effects on T receptor sites.

Last time I checked people with type 2 diabetes have low SHBG. For your information, my energy levels are outrageously high, higher than they ever were on the TRT and I hope that remains to be the case going forward.

183 lbs.

I killed it in the gym today. I feel like a teenager at this testosterone level and I feel better every day.

Two months from now my endo will check total testosterone, SHBG, estrogen, LH and FSH to get baseline levels for future reference. If I ever need TRT in the future, I would have to maintain 100-200 total testosterone.

When the testing is more widely available I plan on checking my AR gene CAG repeat numbers. I pretty much already know what the result will be @madman. :)
IMG_0895.png
 
Are you sure you have type 2? Check out the RADIANT study (ongoing).

I haven’t responded well to diabetes meds either except mounjaro and ozempic, but both exacerbated hypoglycemia.

What did u do about the hypoglycemia? Radiant study? I need to reaearch this as i have been told i have a weird form of diabetuss… reverse hypoglycemia…
 
I have my doubts that TRT will ever work for me. I have identified my issues. Testosterone increases iron uptake by inhibiting hepcidin and regulates iron absorption.

When hepcidin is suppressed, more iron is available for the body to use.

This is precisely my problem. I experience high iron symptoms on TRT eating foods with iron in it, and unless I'm on the verge of an iron deficiency, this is the only time feel normal for a brief time after a blood donation, regardless of the TRT dosage.

I also can’t tolerate vitamin D supplementation on TRT. Vitamin D affects iron bioavailability, further exacerbating the issue. I have no problems while off TRT and supplementing vitamin D, as long as it’s kept under 2000 units otherwise I will get symptoms of excess iron.

Maybe a peptide can increase my natural T production. It's only been 5 days since stopping Jatenzo and last night my testicles started arching. My HPTA is strong at coming back online even after 7 years on TRT.

I want to get myself into a fasting state most of the day eating one meal per day in the evening but also working out every day.

Maybe a protein shake with peanut butter in the morning?

Can I do this without causing any harm?
If u want to eat like that id suggest the warrior diet by Ori Hofmekler… great read and great way to live
 
I’m back on Jatenzo. The first dose kicked in after a couple hours. Insane energy and mental clarity. I’m going on and staying on for good.

I noticed my motivation is higher!

I don’t expect my hematocrit and hemoglobin to be elevated this time out because my ferritin is on the bottom end where it should be. My last reading was 26, iron saturation 26 and all other markers, MCV, MCHC and MCH mid range.
 

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A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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