1. Gianluca

    Progesterone Cream starting dose?

    What would be a starting dose for Progesterone Cream to resolve a deficiency?
  2. Melissa

    Breakthrough bleeding since April

    I need advice. My case is not straightforward. I am not expecting black and white answers but I would greatly appreciate any educated thoughts and suggestions. I have been trying to figure this out since April 2021. Background: 8 plus years postmenopausal intact female. Started HRT in December...
  3. G

    Does nandrolone activate progesterone receptors?

    I’ve heard and read that nandrolone acts on the progesterone receptor. I’m wondering if this activation replaces taking exogenous progesterone at all, even if nandrolone won’t increase progesterone in the serum.
  4. G

    Progesterone’s effect on prolactin

    Does exogenous progesterone lower prolactin levels?
  5. D

    Serious Low E2 Symptoms. Could Progesterone be the cause? How to lower it?

    Hello, has anyone ever used Pregnenolone with a too high dose and had side effects which could stem from high progesterone? If yes, and you stopped using it, how long till you felt better? Is there a way to lower Progesterone,. as I believe it either lowers my e2 or blocks it from binding to...
  6. G

    Recent Labs 5/17

    Hey everyone, here are some recent lab results using 24mg eod test cyp sub-q/shallow IM for about 6-8 weeks. I feel much more relaxed and anxiety is lower, blood pressure is lower than 50mg twice per week. The problem now is my memory and brain function are quite low. I'm sleeping great...
  7. I

    Elevated progesterone

    I'm struggling to dial in my protocol completely over a year now. I was wondering whether the all-time elevated progesteron I have may be causing me some issues? This was my progesterone before starting TRT, at that point I have never injected any hormones or steroids: Progesteron S 0.2 ng/ml...
  8. DixieWrecked

    Progesterone Dose for Men Was just doing some research on progesterone. Has anyone had it tested and corrected a deficiency? Anyone noticed an improvement in symptoms...
  9. DragonBits

    New thoughts on sleep

    I don't think this has ever been discussed, but it might be important for those of us that often wake up from sleep. Oral contraceptive contain estrogen and progestin, (progestin is an analog of progesterone) which have been shown to increase the elimination half life of caffeine from 5-6 hours...
  10. Gianluca

    Pregnenolone Cream Vs Capsule on downstream metabolites?

    is there any difference for Pregnenolone bypassing the liver on downstream metabolites? is there less conversion to Progesterone? I heard once Dr John Crisler, mentioning how oral pregnenolone may be better for people with anxiety, because it gets converted more into allopregnenolone with the...
  11. 3

    Nandrolone + Micronized Progesterone

    Hello, Does anyone have any experience with Nandrolone only + Micronized Progesterone? I've been told its really good but want to see others opinions before trying it thanks
  12. Gianluca

    Optimal Progesterone level in men?

    Do we know if there is an optimal Progesterone level in men? just a curiosity, I couldn't find anything on line
  13. D

    Pregnenolone to Combat Water Retention

    Hey guys, Been working on trying to reduce my water retention and seem to have hit a brick wall. My estrogen is not too inflated but believe that it may be causing some of my issues. After reading some threads on sodium/potassium ratios I cut out a large potion of my added salt and doubled my...
  14. G

    Pregnenolone, missing piece?

    Just wondering if pregnenolone has been the missing puzzle piece in anyone’s protocol, and if things finally clicked when they added it. Thanks.
  15. S

    Thyroid, Adrenal Fatigue, DHEA? Advice Please!

    The short story is that meet Total test is about 600 on 100mg IM every 5 days. I still have alot of anxiety, mood issues, tremors, fatigue, Ed, sleep issues, blood pressure high, etc. I am even having some hoarseness in my throat near my thyroid. I'm trying to look at other hormones that could...
  16. S

    New User, Looking for advice, Questions about HCG, Thyroid, DHEA, etc.

    At age 33, After years of depression, anxiety, fatigue, weight gain, sleep problems, ed, etc. I convinced my doctor to test my hormones. I was specifically interested in my Cortisol levels due to prolonged profound amounts of physical anxiety. The results of what he tested were; Total...
  17. C

    Pregnenolone kills libido

    Hello, anyone else here whos libido goes down with pregnenolone? I use 50mg day and its totally kills my libido and erection, it took a while to figure it out. Same thing happened with even smallest dosage 500iu/wk hcg in a past. Probably im sensitive to increased progesterone from pregnenolone...
  18. D

    Estrogen Dominance & Progesterone

    Hi, I have the symptoms of high E2 (bloating, mild gyno, ED, low libido, irritability, etc). I have been using Anatrozole but it is a fucking hit or miss, the times I ever felt good tye most it last are from a few days to a few hours. I have also tried to try with lower doses and no AI, but no...
  19. Maca

    Backfilling Progesterone with Estrogen Dominance

     Due to not using HCG for 3 Years (Just testosterone), according to Nelson, this can cause your Pregnenolone and Progesterone levels to crash. My theory is due to having very low Progesterone it is causing Estrogen Dominance and any time I take HCG I am having estrogen side effects even...
  20. P

    HPTA Recovery Log to Re Start Testosterone Production

    Hello everyone. Following my failed attempt at restarting my natural testosterone production, I'm back on HRT in the form of 500iu HCG 3x p/w. ---------------------------------------------------------------------------------- Current issues: Always cold, especially extremities Absent Libido...
  21. J

    Progesterone dosing schedule after endometrial ablation

    Progesterone is often prescribed for postmenopausal women to take during certain days of their cycle. What about women who have undergone endometrial ablation? It’s virtually impossible to tell what part of their cycle they are in. Do they just take a small dose every day? Or just stay on a...
  22. S

    Any Dangers in Skipping a Few Days of Progesterone?

    My wife and I are traveling for the next 5 days. She takes Estrogen cream nightly and 50mg of Progesterone. She packed the estrogen but left the progesterone on the table. Just wondering if anyone knows if its safe to skip the progesterone for 5 days and just take the Estrogen. Conversely she...
  23. P

    Progesterone Levels on TRT

    I’ve seen various accounts of men on TRT with deficient levels of progesterone -- many of whom had normal levels prior to treatment. LH is important for leydig cholesterol -> pregnenolone conversion, and also for adrenal steroidogenesis. HPTA suppression and the subsequent absence of LH is...
  24. W

    Progesterone - where to buy?

    Per my consult, I may be trying 10mg oral Progesterone nightly. But, online all I see is TD creams. Anyone have a good source?
  25. N

    Lab results. Diagnosing ED/Libido

    So trying to figure out why I'm having on/off ED issues. Currently on scripted 200mg test E and 1mg adex, split into twice weekly doses. I pin sub Q Mon nights and Fri mornings. Blood was taken Thursday afternoon. Anything here that might be linked to ED/libido? I see Progesterone is at the...
  26. E

    New Protocol, Elevated RHR/Poor Sleep/Eye Floaters. Abort or Stay the Course?

    Basic Info I'm 6 days into a major protocol change overseen by Defy Medical and feeling really strange and unsettling side effects. There are some confounding factors that are making it hard for me to know what to do. Defy is closed for a few days for the holiday so I can't get a consult and...
  27. A

    Progesterone for sleep

    Did anyone used progesterone successfully for better sleep? Especially to stay asleep at night and to calm down the mind. I've been tested for progesterone and the level was 0.10 ng/mL (range 0.10 – 1.00 ng/mL). Several TRT doctors refuse to prescribe progesterone due to be highly inflammatory...
  28. xqfq

    Could the ratio of progesterone to estradiol affect water retention in men on TRT?

    I've been doing reading on water retention on TRT and I'd like to discuss a hypothetical I haven't seen floated: that the ratio of progesterone to estradiol could play a role. This is a good post by Nelson: "Water Retention Caused by Testosterone May Have Nothing to Do with Estradiol". The...
  29. S

    IVF Meds Menopur and Progesterone for Men?

    My daughter tried IVF last year (unsuccessfully) and has a few boxes of Menopur menopropins and Progesterone left over. Is this a brand name drug thats really HCG? My doctor may put me on HCG soon and I was planning to bring them in to him ask him about this. Does anyone know if this is the...
  30. Gianluca

    Low 17-OH Progesterone a concern?

    I was surprised 17-OH Progesterone was low <10 on LabCorp scale 27-199 ng/dl considering along with TRT I'was on HCG 125Iu daily 50mg Pregnelonone and 25mg of Hydrocotisone I actually thought because I'm on Hydrocortisone Progesterone would be high(er) Why would that be low?
  31. S

    Optimal PROGESTERONE for women on HRT ?

    Hi. My mother started hrt recently (T injections 2x5mg/week. Estradiol patch 3.8mg (replace it every 7 days) and oral progesterone 100mg every day) She is 56 in menopause Her labs on this protocol are T>> 116ng/dl 2 days after injection e2>> 30 pg/ml...