Wrong Estradiol assay. How big of a deal?

BryanW

Member
Hello - new guy here. Currently going through new patient on-boarding activities for Defy Medical. I had a physical performed by a PA, and I had him enter the blood test Rx from Defy. When I got to the lab, I noticed that the regular Estradiol test was listed. Apparently the PA entered it as such. I asked the lab techs to change it to the sensitive version but they looked at me like I was speaking Greek. Later that day, I called the main lab and again asked that they submit the sample to Labcorp as the sensitive assay.

Blood tests are now coming in and I see that the regular Estradiol test was used :(.

How much of a problem will this be in evaluating my situation?
 
Thanks. I just sent an email to Chelsea, she has been pretty responsive to questions.

Also, my results are low 7.2 pg/mL (7.6-42.6). From my brief reading on this topic, it seems the biggest problem with the regular E2 test is over-estimating estradiol.
 
Thanks. I just sent an email to Chelsea, she has been pretty responsive to questions.

Also, my results are low 7.2 pg/mL (7.6-42.6). From my brief reading on this topic, it seems the biggest problem with the regular E2 test is over-estimating estradiol.

That is true. There are members here who've seen just the opposite, but it is rare. The bottom line is that it just isn't reliable.
 
Thanks. I just sent an email to Chelsea, she has been pretty responsive to questions.

Also, my results are low 7.2 pg/mL (7.6-42.6). From my brief reading on this topic, it seems the biggest problem with the regular E2 test is over-estimating estradiol.

Post the rest of the results if you want feedback from members here.

That is very low, chances are you're lower than that, but it does underestimate sometimes.

Do you have low E2 symptoms? http://dosagemayvary.com/high-estrogen-vs-low-estrogen-symptoms-for-men/
 
I will post results when they all come in. E2 was one of the first results reported.

I do have symptoms: ED (both difficulty achieving and losing it during sex). Also chronic fatigue and lack of motivation. I have joint clicks and pops, but I can live with that.
 
I will post results when they all come in. E2 was one of the first results reported.

I do have symptoms: ED (both difficulty achieving and losing it during sex). Also chronic fatigue and lack of motivation. I have joint clicks and pops, but I can live with that.

That's usually a low E2 symptom
 

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Predict estradiol, DHT, and free testosterone levels based on total testosterone

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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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