Very High DHEA-S (824) concerned and confused

mor1987

New Member
I began TRT 4 years ago. When I first got my bloods, it showed a DHEA-S level of around 650. My doctor wasn't concerned and I believe he said my adrenals were just healthy and working hard. He said it's a concern if they continue to go up. Overtime, they have fluctuated between 650 and 775. Recently, my bloods showed 824. This time he seemed concerned and ordered an ACTH Plasma test and a Saliva Cortisol test. Both came back normal.

I'm waiting to discuss these results this week but I'm wondering if anyone has had this issue and knows anything about it? Does normal coritsol levels mean something more serious going on? All high DHEA information online seems to be about females.
 

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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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