DHEA and Pregnenolone best times to take

Defy Medical TRT clinic doctor
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Mfri225

New Member
I am taking 25 mg of DHEA and 5 mg of pregnenolone. My DHEA levels have lowered over time and my latest labs showed it was significantly low and decided I wanted to give it a try. I am on enclomiphene 12.5 EOD. I was taking DHEA and Pregnenolone after dinner and the other night I had a panick attack in the middle of the night out of my sleep which was odd. My heart rate was through the roof; I was burning up it was unpleasant. Is it best to take DHEA in the AM and Preg in the PM? Or both in the AM?
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Defy Medical TRT clinic doctor
Defy Medical TRT clinic

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