Very basic question regarding how to adjust AI dosages based on T dosages

Pacman

Active Member
I been on TRT for 10 years at this point. I find that my current default "sweet spot" (as far feeling good and having a fairly high sex drive and function) revolves around the 100-130 mg T cyp every 3 days with no AI.

Occasionally though I like to experiment with different dosages (in both directions) to see how I react and feel on them, including going above the general max therapeutic weekly dosage at times.

I've found (although not always the case) that when I inject higher dosages, my sex drive and function tend to both drop pretty drastically (much less random boners and desire to ejaculate). And this is going from 100-125ish mg T cyp (with no AI) in an injection to 150ish mg T cyp with an AI one day later (0.125 mg anastrozole, per injection), so not a HUGE difference per se.

Same frequency of injections in both cases (every 3 days).

And it leaves me wondering, is the decreased sex drive and function due to:
1) Increased testosterone beyond what I should have?
2) Increased estrogen?
3) Decreased estrogen? (I know it's only 0.125 mg, but maybe they affect my heavily)

So it makes me wonder, should I try taking 2 or 3 more AIs with increased dosages, or should I not take them at all?

I know it really does depend on individual response, but how am I able to take increased dosages of T injections without negatively affecting my sex drive and function?
 

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Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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