TRT Dosage too High

Schnitzel

New Member
Hello,

I started TRT 10 weeks ago with 386 ng/dl.
I do 20 units every three days.
I also donate blood and my Hemoglobin (Hgb) is 15.5
My recent lab results show 1464.00 ng/dl testosterone.
My question is: How much shall I lower the injections? 30%, 40%, or 50% to get to around 850 ng/dl?

Thank you.
 
Hello,

I started TRT 10 weeks ago with 386 ng/dl.
I do 20 units every three days.
I also donate blood and my Hemoglobin (Hgb) is 15.5
My recent lab results show 1464.00 ng/dl testosterone.
My question is: How much shall I lower the injections? 30%, 40%, or 50% to get to around 850 ng/dl?

Thank you.

The most common strength used TC/TE 200 mg/mL.

U-100 insulin syringe

1 ml = 100 units

0.01 mL = 1 unit = 2 mg TC/TE


You are injecting .20 mL (20 units) = 40 mg T every 3 days (93.3 mg T/week).

The standard starting dose is 100 mg T/week or 50 mg every 3.5 days.

Your weekly dose of T is not that high yet you are still hitting a whopping TT 1464 ng/dL.

The s**t kicker here is how many days post-injection were your labs done as we always want to test at the true trough (lowest point) before your next injection.

Seeing as you are injecting every 3 days there is going to be a difference between the peak--->trough as true peak would be achieved within 24 hrs post-injection which means. your trough will be lower.

Top it off that you are missing the most critical blood marker here free testosterone.

Although TT is important to know FT is what truly matters here as it is the unbound fraction responsible for the positive effects.

TT means nothing without knowing where your FT truly sits.

Most men hitting a very high trough TT on doses <100 mg/week would have highish/high SHBG.

Even then if your TT is a whopping 1464 ng/dL and you have high SHBG it is a given that your FT would be high-end/high but again was this at or closer to your peak or true trough as it will make a big difference here on your next move.

What is your SHBG?

Any time the dose is titrated whether going up or coming down 20-25 mg T would be a sensible move on moving your numbers in the right direction.

Again before even considering lowering your dose you need to let me know how many days post-injection your labs were done and we need to find out where your FT sits.
 
Thank you, madman, for your response.
The injection was about 36 hours before the blood work (test).
The lab results do not show any SHBG and no Free Testosterone, despite I told him to do it.
 
Thank you, madman, for your response.
The injection was about 36 hours before the blood work (test).
The lab results do not show any SHBG and no Free Testosterone, despite I told him to do it.

So you tested closer to your peak as this is not your true trough (lowest) point before your next injection which would be 72 hrs post-injection.

Even then your trough TT will still be high but again we need to know where your trough FT sits.

You have two option here.

The only way to know where your trough FT truly sits would be testing using the most accurate assay the gold standard Equilibrium Dialysis especially in cases of altered SHBG.

You can easily pay out of pocket if your insurance does not cover the cost and use Nelson's discounted labs which uses Quest Diagnostics for testing or you can use Labcorp or Mayo Clinic as they all offer the gold standard ED assay.

Every panel includes the most accurate testing methods for TT (LC-MS/MS) and FT (Equilibrium Dialysis).








If you do not have access to such which would only apply to people living outside of the US as it is not widely available then you would need to use/rely on the next best testing method the go to calculated linear law-of-mass action Vermeulen (cFTV) which will give a good approximation.

In order to calculate your FT you need to plug in your TT, SHBG and Albumin using the online calculator which is available for free to the general public.

If you do not know where your Albumin sits then you can use 4.3 g/dL (default).


 
Hello,

I started TRT 10 weeks ago with 386 ng/dl.
I do 20 units every three days.
I also donate blood and my Hemoglobin (Hgb) is 15.5
My recent lab results show 1464.00 ng/dl testosterone.
My question is: How much shall I lower the injections? 30%, 40%, or 50% to get to around 850 ng/dl?

Thank you.
Get real labs before you think about changing anything and test at trough. Need to see SHBG / free T, total T is almost meaningless on its own, and the timing of your last test was wrong.
 
Thank you for your replies.
I will check with my doc if he can do this test.
Just for my understanding: The test is called "Quest Diagnostics" and includes automatically TT (LC-MS/MS) and FT (Equilibrium Dialysis) or do I have to tell him exactly to include these?
Is there anything else I need?
If he cannot do it, I will use your "Nelson's discounted labs".
 
Thank you for your replies.
I will check with my doc if he can do this test.
Just for my understanding: The test is called "Quest Diagnostics" and includes automatically TT (LC-MS/MS) and FT (Equilibrium Dialysis) or do I have to tell him exactly to include these?
Is there anything else I need?
If he cannot do it, I will use your "Nelson's discounted labs".

Tell your doctor that you want to have your TT/FT tested through Quest and give him the test code (36170) which needs to be written on your requisition.


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1782681468196.webp
 
One more: When I go to "Nelson's discounted labs", it only gives me five to chose from but no Quest Diagnostics.

I already provided you the link in post #4.

Just click the link and then add the test to your cart.

You will have your blood work done at Quest Diagnostics.


$63
 

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