If blood work was done at true trough then you are hitting a high-end trough TT 950 ng/dL with normal SHBG 30 nmol/L which would have you hitting a high trough cFTV 24 ng/dL yet f**king with that AI has your trough estradiol in the DIRT!
This guy should not be treating men!
Ridiculous telling a man that his estradiol needs to be lower than 20!
Last thing you want to do here is drive one of Ts most critical metabolites into the ground!
Estradiol and DHT are needed in healthy amounts to experience the full spectrum of testosterone-beneficial effects on (cardiovascular health, brain health, libido, erectile function, bone health, tendon health, immune system, lipids, and body composition).
Late Onset Hypogonadism (LOH): bone health
Abstract
Background. Bone health is underdiagnosed and undermanaged in men. Bone loss occurs in men with hypogonadism and in aging men. Thus, patients with a diagnosis of late-onset hypogonadism (LOH) are at risk of osteoporosis and osteoporotic fractures.
Objectives. To provide an update on research data and clinical implications regarding bone health in men with LOH by reviewing literature articles on this issue.
Materials and Methods. A thorough search of listed publications in PubMed on bone health in older men with...
* From a pathophysiological perspective, the detrimental effects of testosterone (T) deficiency on BMD are partly ascribed to relative estrogen deficiency and both serum T and serum estradiol (E2) needs to be above 200 ng/dL and 20 pg/mL to prevent bone loss.
Figure 1. Circulating sex steroids and bone pathophysiology in men: relationship between serum T, E2, individual factors involved in the conversion of T into E2, putative thresholds for serum T 20,79 and E 220,34,47,80-82, and bone health.
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Figure 1 339x190 mm ( x DPI)
Bone Structure: The Key Players Under the Magnifying Glass
Testosterone in men is mainly secreted by the gonads, with minor contributions from the adrenal cortex. Testosterone and DHT exert their effects through the androgen receptor (AR). Testosterone can be aromatized to bind estrogen receptors (ER and ER) (20, 21). AR and ERs are expressed on osteoblasts and osteocytes, though their presence...
Role of sex steroids hormones in the regulation of bone metabolism in men: Evidence from clinical studies (2022)
Pawel Szulc, MD, Ph.D., Senior Research Fellow
Sex steroids regulate bone metabolism in young men during growth and consolidation. Their deficit during growth compromises longitudinal and radial growth of bones and has a negative impact on body height, bone width, peak areal bone mineral density (BMD), and bone microarchitecture. In older men, the deficit of sex steroid hormones (mainly 17b-estradiol) contributes to a high bone turnover rate, low BMD, poor...
The EAU Guidelines Office will provide a state-of-the-art update on male hypogonadism and testosterone replacement therapy. This recording will be of great educational value for urologists as internationally-known experts will focus on the controversial and challenging areas of this rapidly evolving field, and provide you with vital insights.
Testosterone replacement therapy is indicated in a variety of clinical conditions and has shown to improve the quality of life in patients with hypogonadism. In addition, the therapy may also have...
Study: Low estrogen can cause problems for men
Study: Low estrogen can cause problems for men (2013)
Dr. Joel Finkelstein, an endocrinologist at Harvard Medical School and the lead author of a new study, talks about the effects of declining estrogen in men.
Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men (2013)
Joel S. Finkelstein, M.D., Hang Lee, Ph.D., Sherri-Ann M. Burnett-Bowie, M.D., M.P.H., J. Carl Pallais, M.D., M.P.H., Elaine W. Yu, M.D., Lawrence F. Borges, M.D., Brent F. Jones, M.D., Christopher V...
As we very well know T s metabolites estradiol and DHT are needed in order to reap full beneficial effects of testosterone.
Ts metabolites estradiol and DHT are needed in healthy amounts to experience the full spectrum of testosterones beneficial effects on (cardiovascular health, brain health, libido, erectile function, bone health, tendon health, immune system, lipids, and body composition).
Detailed Briefing Document: Metabolic Benefits of Estradiol and Testosterone in Both Sexes
Source: Mauvais-Jarvis, F., & Lindsey, S. H. (2024). Metabolic benefits afforded by estradiol...
Hot off the press!
25th Annual Fall Scientific Meeting of SMSNA!
Grapevine, Texas!
Great presentation!
1:29:40-1:43:30
Conclusions
Abstract
Oestradiol (E2), a steroid hormone derived from cholesterol, has long been recognized for its central role in female reproduction and pathobiology of menopause. However, accumulating evidence underscores a critical role for E2 in the regulation of systemic metabolism in both women and men. The metabolic actions of E2 are predominantly mediated by oestrogen receptor α (encoded by ESR1), a nuclear receptor with heritable expresion patterns and tissue-specifc transcript levels highly correlated with indices of metabolic health in both sexes. Here we...
