Higher Numbers on IM vs SQ

Tman

Active Member
I've injected SQ since starting TRT two years ago. In my search to lower E or at least the effects and to benefit from TRT, I started injecting my deltoids, for this blood work cycle. That was the only change. My total T was up by 300 and my FT was up by about 80 and my ASL was outside the zone, high by 20 points. I didn't really notice any impact on my physical or mental well being. I inject daily and tested 39 hours after testing, which (actually) was about 14 hours later than I normally test. I could not schedule an appointment for the afternoon after dosing, like normal, so I had to wait until the following morning. That means, at least to me, that my numbers were probably even higher at my normal testing, 24 hourish mark. I was on my same AI dose, and my E number was about my typical. So, with the much higher T numbers and similar E number, it appears that the IM approach did help with E.

Not looking for feedback...just sharing my experiences. I meet with the doc next week. He might want to cut my dose back, but I'm leaning towards returning to SQ. It's just so much easier and I felt about the same on both.
 
I also get significatnly higher total t on the same dose with IM compared to sub q and also feeling very different. Night and day difference, I wouldnt try sub q ever again.

And by IM I do not mean this trendy shallow IM thing(tried that as well and worked as bad as sub q), but old school real IM deep into the muscle. For me this is the only stable and secure delivery method.
 
I've been alternating between SubQ and shallow IM. First time ever. In the past, I've only done shallow IM. Will be having labs tomorrow morning.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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