Trans scrotal testosterone cream application is a game changer

So I was on injections of Testosterone cyp for almost 4 years before switching over to scrotal testosterone cream application. Let me tell you it has been absolutely amazing how much better I feel on the cream verses the injections. I dose it at 150 mg daily (3 clicks), 50 mg in the morning before bed (I work nights) and 100 mg about an hour before I leave for work at night. I was doing daily sub q injections for the past couple years, 20 mg cyp daily. I felt good on that protocol, but this blows that protocol out of the water. I messed up and did labs about 2 hours after my application and everything came back out of range, with free t at 48. I would encourage anyone interested to give the scrotal t-cream application a go, I can't see myself ever going back to injections.

 

Gocha. So would u say that ur currently not feeling as good as u did the first few months on the cream, but pretty close? Or ur basically feeling as good as u did when starting the cream? Just want to clarify

overall it sounds like ur currently doing pretty damn good. Might not be 100%, from the sounds of it, but feeling good enough to not worry about tweaking anything protocol wise is honestly a great place to be, and pretty much the goal for most of us I would assume

Assuming my lingering issues aren’t “trt” related, I’m doing well. but I feel very similar to when I started the cream. i thought my headaches were caused by injections, but could be wrong. But I’ve also been messing with other things, like coming on and off ssris and on and off caffeine

 

I don’t handle high levels on injections very well, so I started with 50 mg 2x day….was around 1200 w FT at 30, DHT was 250, E2 at upper 50s….dropped down to just one click a day and was 720 total 5 hrs after application….

Wow man that’s amazing. I take 5 clicks daily of empowers hydrogel (still cream) just to reach 800tt and 20ft 5 hours after my 3 clicks in the am.

 

Assuming my lingering issues aren’t “trt” related, I’m doing well. but I feel very similar to when I started the cream. i thought my headaches were caused by injections, but could be wrong. But I’ve also been messing with other things, like coming on and off ssris and on and off caffeine

You're having mood issues and headaches going on and off SSRIs and caffeine, while TRT protocol was stable? In that case, I would bet the house that your symptoms are related to what you're doing with the SSRI and caffeine. SSRIs can cause both symptoms, either while taking them or while withdrawing. Caffeine withdrawal also causes both and is really underestimated by folks, particularly the duration of mood disturbance it can cause, which can last for months in some cases.

 

You're having mood issues and headaches going on and off SSRIs and caffeine, while TRT protocol was stable? In that case, I would bet the house that your symptoms are related to what you're doing with the SSRI and caffeine. SSRIs can cause both symptoms, either while taking them or while withdrawing. Caffeine withdrawal also causes both and is really underestimated by folks, particularly the duration of mood disturbance it can cause, which can last for months in some cases.

Yeah. I had these strange headaches since starting trt and quitting ssri 3 years ago. And then when I went on cream (while off caffeine) for 6 months they went away. Or at least got much better. Then I started tinkering with shit an all hell broke loose. That’s another problem with these forums. Many guys leave out key details like this and start messing with their protocol.

I’m still not 100% sure why I have mood issues that started after beginning trt. Can be the shutdown job stress. Having two young kids. very hard to nail down. But I do notice the more I chase fixing it the worse I feel. Especially messing with hormones and ssri medications. I was doing pretty well on cream only.

 

Wow man that’s amazing. I take 5 clicks daily of empowers hydrogel (still cream) just to reach 800tt and 20ft 5 hours after my 3 clicks in the am.

Yeah….only other place I tried it was on inner thigh and I didn’t absorb it hardly at all….guess my scrotal skin is like rice paper

 

Yeah….only other place I tried it was on inner thigh and I didn’t absorb it hardly at all….guess my scrotal skin is like rice paper

Have you ever tried cream with daily tadalafil? cream gave me better erections then injection on its own. But with tadalafil they are fantastic.

 

More than likely it’s not a dip in t (at least in the blood ) you respond pretty well to the cream. I don’t respond as well and I don’t have the energy dips. Like today I put more on in the morning and skipped my evening dose and still feel the same

You are probably correct. But, I also wonder if one's tendency to absorb can change over time. Another untested theory.

 

Yeah….only other place I tried it was on inner thigh and I didn’t absorb it hardly at all….guess my scrotal skin is like rice paper

@TLR, are the numbers above you quote all with scrotal application? I had crazy numbers with scrotal application. I have since rotated dose and site (lower scrotal dose; combo of scrotal and extremity; extremity only). Anecdotally, I think my shoulders absorb well and upper inner thigh does not absorb well. Purely conjecture.

 

You are probably correct. But, I also wonder if one's tendency to absorb can change over time. Another untested theory.

most likely it would be from variation in the batch. I know plenty of guys in another group that have been on scrotal cream for 4+ years and no issues. Numbers always close. It seems that medquest pharmacy is the most reliable since they 3rd party batch test.

cream for me is simple. I can now tell without labs where my numbers sit based off erections. So if I lose my night wood I know my numbers have dipped. I’ve tested the theory and i was proven right. But for the most part my erections have been consistent on 4-5 clicks daily and the numbers jive. I’ve been on cream for 10+ months.

 

@TLR, are the numbers above you quote all with scrotal application? I had crazy numbers with scrotal application. I have since rotated dose and site (lower scrotal dose; combo of scrotal and extremity; extremity only). Anecdotally, I think my shoulders absorb well and upper inner thigh does not absorb well. Purely conjecture.

Yes…one click (50 mg) from Empower got me to 720 TT five hours after application….I never tried it anywhere else except for inner thigh and my levels dipped bad (200’s with 100 mg)….I felt better on cream in most ways OTHER than the erectile function issues….Ive read that issue will go away with some patience, but I gave it a good 6 weeks at the higher dose…that’s why I dropped down to 1 click thinking it would fix it….it made it a little better, but not as good as injections.

 

Yes…one click (50 mg) from Empower got me to 720 TT five hours after application….I never tried it anywhere else except for inner thigh and my levels dipped bad (200’s with 100 mg)….I felt better on cream in most ways OTHER than the erectile function issues….Ive read that issue will go away with some patience, but I gave it a good 6 weeks at the higher dose…that’s why I dropped down to 1 click thinking it would fix it….it made it a little better, but not as good as injections.

Any theories on why u had better erections on injections?

 

Any theories on why u had better erections on injections?

At the risk of sounding like I’m “blaming” estrogen, It was around 60 and my estrone was sky high (I don’t remember the number) on the 100 mg a day….and I may not have been patient enough with the 50 mg to let things settle….on injections I take 70-80 mg a week and my E2 is always in the high twenties / low thirties….in the past when I took higher doses on injections I noticed anytime my E2 gets in the 40s or higher it has that effect…..according to some, when using the cream that is common and you are supposed to just wait it out…..but having a half limp switch isn’t something I can be that patient with I guess.

 

At the risk of sounding like I’m “blaming” estrogen, It was around 60 and my estrone was sky high (I don’t remember the number) on the 100 mg a day….and I may not have been patient enough with the 50 mg to let things settle….on injections I take 70-80 mg a week and my E2 is always in the high twenties / low thirties….in the past when I took higher doses on injections I noticed anytime my E2 gets in the 40s or higher it has that effect…..according to some, when using the cream that is common and you are supposed to just wait it out…..but having a half limp switch isn’t something I can be that patient with I guess.

Ya honestly it sounds like the higher E2 could have been throwing ur erections off. Can’t say for sure. But nobody can say for sure it wasn’t what was messing with ur erections either

and good for u for testing E1. It’s a very weak estrogen, compared to E2, but it obv must still have some effect.

Now another question. Any theories on why the cream makes u feel better in every other way compared to injections? Too bad u didn’t know for sure why, and then could try to recreate the same benefits with injections, while also having good erections

 

Ya honestly it sounds like the higher E2 could have been throwing ur erections off. Can’t say for sure. But nobody can say for sure it wasn’t what was messing with ur erections either

and good for u for testing E1. It’s a very weak estrogen, compared to E2, but it obv must still have some effect.

Now another question. Any theories on why the cream makes u feel better in every other way compared to injections? Too bad u didn’t know for sure why, and then could try to recreate the same benefits with injections, while also having good erections

I honestly cant tell you why for sure, but I normally don’t handle my levels being that high on injections very well….it jacks me up, worsens anxiety and actually worsens “brain fog”…..the cream gave me a burst of energy but just felt “cleaner” for lack of a better word, at levels that I cannot tolerate on injections. Don’t know if it’s the increased DHT, the stability of the levels and shorter half life? All I know is my “thumper” didn’t want to work half the time, and even when it did it required constant stimulation to keep it going….if not for that issue I’d be on it right now….

 

I honestly cant tell you why for sure, but I normally don’t handle my levels being that high on injections very well….it jacks me up, worsens anxiety and actually worsens “brain fog”…..the cream gave me a burst of energy but just felt “cleaner” for lack of a better word, at levels that I cannot tolerate on injections. Don’t know if it’s the increased DHT, the stability of the levels and shorter half life? All I know is my “thumper” didn’t want to work half the time, and even when it did it required constant stimulation to keep it going….if not for that issue I’d be on it right now….

I had a very similar experience with cream. It does feel "cleaner" and I am able to easily tolerate levels of testosterone that would destroy me with anxiety and insomnia if I reached the same level with injections.

I'm going to experiment with pharma injections that are free of benzyl benzoate and benzyl alcohol to see if that makes a difference compared to compounded injections.

 

At the risk of sounding like I’m “blaming” estrogen, It was around 60 and my estrone was sky high (I don’t remember the number) on the 100 mg a day….and I may not have been patient enough with the 50 mg to let things settle….on injections I take 70-80 mg a week and my E2 is always in the high twenties / low thirties….in the past when I took higher doses on injections I noticed anytime my E2 gets in the 40s or higher it has that effect…..according to some, when using the cream that is common and you are supposed to just wait it out…..but having a half limp switch isn’t something I can be that patient with I guess.

What’s the longest you’ve been on cream ?

 

I honestly cant tell you why for sure, but I normally don’t handle my levels being that high on injections very well….it jacks me up, worsens anxiety and actually worsens “brain fog”…..the cream gave me a burst of energy but just felt “cleaner” for lack of a better word, at levels that I cannot tolerate on injections. Don’t know if it’s the increased DHT, the stability of the levels and shorter half life? All I know is my “thumper” didn’t want to work half the time, and even when it did it required constant stimulation to keep it going….if not for that issue I’d be on it right now….

I’m assuming the cream suppresses the HPTA less, and therefore messes with downstream hormones less, and that’s most likely where the improved cognitive function and feeling “cleaner” comes from on the cream. I could be wrong obv, but that’s my best guess currently. I think there’s a good chance the fact that cream doesn’t have an ester attached, and is truly the same bioavailable test that we produce endogenously, could have something to do with it. As well as the cream not having any of these toxic preservatives and excipients in it. Even in very small quantities, I’m sure they’re not good to be injecting on a regular basis

I theorize that the higher levels on injections causing u to feel jacked up and anxious is probably due to the lack of downstream hormones/ metabolites to balance out the higher test and DHT levels.

 

I’m assuming the cream suppresses the HPTA less, and therefore messes with downstream hormones less, and that’s most likely where the improved cognitive function and feeling “cleaner” comes from on the cream. I could be wrong obv, but that’s my best guess currently. I think there’s a good chance the fact that cream doesn’t have an ester attached, and is truly the same bioavailable test that we produce endogenously, could have something to do with it. As well as the cream not having any of these toxic preservatives and excipients in it. Even in very small quantities, I’m sure they’re not good to be injecting on a regular basis

I theorize that the higher levels on injections causing u to feel jacked up and anxious is probably due to the lack of downstream hormones/ metabolites to balance out the higher test and DHT levels.

Not for me
on paper. My preg levels are bottomed out on cream. they weren’t on injections. And my testicle atrophy is the same on cream vs injections

 

Not for me
on paper. My preg levels are bottomed out on cream. they weren’t on injections. And my testicle atrophy is the same on cream vs injections

Interesting. Is it a thing tho where when pregnenolone is being used up to convert into other downstream hormones it can show low in a blood test? Not sure if it is, jw if that’s possibly how it works. Kind of like how guys on TRT can have lower ferritin levels, because iron is being used up at a higher rate while on TRT.

does atrophied testicles automatically mean less downstream metabolite production? Does pregnenolone go through the testicles to produce metabolites such as prog, DHEA, allopregnenolone and cortisol, to name a few, or is it a completely separate conversion process that has nothing to do with what’s going on in the testicles?

 

Interesting. Is it a thing tho where when pregnenolone is being used up to convert into other downstream hormones it can show low in a blood test? Not sure if it is, jw if that’s possibly how it works. Kind of like how guys on TRT can have lower ferritin levels, because iron is being used up at a higher rate while on TRT.

does atrophied testicles automatically mean less downstream metabolite production? Does pregnenolone go through the testicles to produce metabolites such as prog, DHEA, allopregnenolone and cortisol, to name a few, or is it a completely separate conversion process that has nothing to do with what’s going on in the testicles?

I often wondered that too. An old member I used to speak to on a regular basis lived by that same theory. That’s why blood testing for hormones is very tricky. We have no idea what’s actually going on in the cells.