The significance of selegiline/(-)-deprenyl after 50 years in research and therapy (1965-2015)

[Gman86]

Yes sir. This is a lifetime protocol for me.

Ya I remember u saying that u made the decision to take it indefinitely. Since the last time u talked about it on here, have u tried upping ur dose, and/ or taking it sublingually? And I forget, do u take the 5mg orally upon waking, or with food? TIA

 

[Gman86]

@Cataceous do u take selegiline still? I’m looking through my selegiline notes and I see that at one point u were taking 3mg orally per day. Think that was back in 2022 tho

 

[Cataceous]

@Cataceous do u take selegiline still? I’m looking through my selegiline notes and I see that at one point u were taking 3mg orally per day. Think that was back in 2022 tho

Yes, I've been taking 2.5 mg/day consistently.

 

[Gman86]

Yes, I've been taking 2.5 mg/day consistently.

And u take it orally, correct? Do u take it upon waking on an empty stomach, or with food? Thanks for quick reply

 

[Cataceous]

And u take it orally, correct? Do u take it upon waking on an empty stomach, or with food? Thanks for quick reply

I do take it orally, on waking with an empty stomach.

 

[lebroseixoife]

I do take it orally, on waking with an empty stomach.

What have you found to be beneficial to taking it regularly? What side effects do you experience?

 

[Guided_by_Voices]

Hey @Gman86 , are you still taking Selegiline? How did you get your doctor to prescribe it?
How would one Selegiline down to 1mg from 5mg? What kind of solution would I use to do volumetric dosing?

I cut the pills in half. They are quite small but they could be cut again with a pill splitter but I am fine with the 2.5 mg dose, at least in theory since I don't feel anything similar to Gman.

 

[Cataceous]

What have you found to be beneficial to taking it regularly? What side effects do you experience?

I can't say with certainty, but I think it's associated with improved mood and motivation. There are no side effects that I'm aware of.

 

[Gman86]

I cut the pills in half. They are quite small but they could be cut again with a pill splitter but I am fine with the 2.5 mg dose, at least in theory since I don't feel anything similar to Gman.

Do u also take it orally upon waking?

 

[Guided_by_Voices]

Do u also take it orally upon waking?

yes, several days per week usually

 

[SkiDaddy]

At 2.5 to 5mg. has anyone noticed any Blood Pressure changes?

 

[BadassBlues]

At 2.5 to 5mg. has anyone noticed any Blood Pressure changes?

None, but it can increase the effects of stimulants.

 

[dirkdigglr]

does anybody have experience with rasagiline?

 

[FunkOdyssey]

I'm going to try 2.5 mg orally again now that I'm old enough for it to make sense (almost 45). ChatGPT keeps telling me to try it for various reasons. Started today. I'll let you know how it turns out.

 

[FunkOdyssey]

I'm going to try 2.5 mg orally again now that I'm old enough for it to make sense (almost 45). ChatGPT keeps telling me to try it for various reasons. Started today. I'll let you know how it turns out.

Took 2.5 mg yesterday morning. Felt overstimulated in the first part of the day, mediocre in the afternoon, completely crashed in the evening. Didn't want to repeat that today. Going to shelve the idea for now.

 

[BadassBlues]

Took 2.5 mg yesterday morning. Felt overstimulated in the first part of the day, mediocre in the afternoon, completely crashed in the evening. Didn't want to repeat that today. Going to shelve the idea for now.

Did you combine it with caffeine or other stimulants?

 

[FunkOdyssey]

Did you combine it with caffeine or other stimulants?

No, I'm caffeine-free. I would guess it was the amphetamine metabolites causing most of the noticeable effects, as I took one sublingual dose some months ago and didn't really feel anything noticeable at all.

 

[BadassBlues]

No, I'm caffeine-free. I would guess it was the amphetamine metabolites causing most of the noticeable effects, as I took one sublingual dose some months ago and didn't really feel anything noticeable at all.

Interesting that it affected you so strongly. It may be worth another shot, might have been a one off.