THE MYOCENTRIC VIEW OF CREATINE SUPPLEMENTATION MAY BE INCOMPLETE: BRAIN, BONE, HEART, IMMUNE SYSTEM?

[madman]

Thread 'Creatine Supplementation and the Brain'

Mar 21, 2026

* There is evidence that CrS increases brain creatine, but this response may be dose and/or duration dependent. CrS provides some benefits during acute periods of metabolic stress such as sleep deprivation, mental fatigue, and hypoxia. Emerging clinical data also suggest potential therapeutic effects from CrS for Alzheimer’s disease, major depressive disorder, and mild traumatic brain injury (mTBI), although findings across conditions remain preliminary and inconsistent. Further, CrS shows some promise for improving aspects of sleep quality. ...

• madman
• creatine; brain health; muscle/strength
• Replies: 6
• Forum: Nutrition and Supplements

 

[madman]

Thread 'The emerging and evolving evidence supporting creatine as an ergogenic aid: history and applications'

Apr 11, 2026

• madman
• creatine; exercise; strength/muscle; brain
• Replies: 4
• Forum: Nutrition and Supplements

 

[madman]

Thread 'Creatine for Muscle, Bone, Brain & Longevity (Plus Caffeine, Dosing, and Safety)'

May 19, 2026

07:17 Top Supplements Today
08:23 NAD Hype vs Evidence

In this episode of the Flex Diet Podcast, I sit down with creatine researcher Dr. Darren Candow from the University of Regina to break down what the research actually says about creatine for muscle, performance, and body composition—plus the newer interest in brain health, aging, and longevity.

We dig into practical dosing (including higher-dose ideas for bone and brain), why timing probably doesn’t matter much, and what the data shows on safety, side effects, and common...

• madman
• creatine; health/fitness; aging
• Replies: 1
• Forum: Nutrition and Supplements

 

[madman]

Thread 'Creatine: New Insights for Muscle, Bone and Brain'

May 29, 2026

• madman
• creatine; muscle; brain; bone; immune system
• Replies: 1
• Forum: Nutrition and Supplements

 

[madman]

Thread 'What is creatine really doing to your brain?'

Monday at 6:33 PM

What is creatine really doing to your brain? Top Creatine Researcher Dr Darren Candow reveals why 5g won’t reach your brain, how creatine may reverse sleep deprivation, and the 5 myths stopping millions from taking it!

Dr Darren Candow is a professor and Director of the Ageing Muscle and Bone Health Laboratory at the University of Regina, with 175 published research papers. He is a fellow and incoming Vice-President of the International Society of Sports Nutrition and was named on Stanford University's Top 2% Scientists list in 2025.
He explains...

• madman
• creatine; brain health; muscle/strength
• Replies: 1
• Forum: Nutrition and Supplements