THE MYOCENTRIC VIEW OF CREATINE SUPPLEMENTATION MAY BE INCOMPLETE: BRAIN, BONE, HEART, IMMUNE SYSTEM?

madman · Mar 21, 2026

Thread 'Creatine Supplementation and the Brain'

Mar 21, 2026

* There is evidence that CrS increases brain creatine, but this response may be dose and/or duration dependent. CrS provides some benefits during acute periods of metabolic stress such as sleep deprivation, mental fatigue, and hypoxia. Emerging clinical data also suggest potential therapeutic effects from CrS for Alzheimer’s disease, major depressive disorder, and mild traumatic brain injury (mTBI), although findings across conditions remain preliminary and inconsistent. Further, CrS shows some promise for improving aspects of sleep quality. ...

madman · Apr 11, 2026

Thread 'The emerging and evolving evidence supporting creatine as an ergogenic aid: history and applications'

Apr 11, 2026

madman · May 19, 2026

Thread 'Creatine for Muscle, Bone, Brain & Longevity (Plus Caffeine, Dosing, and Safety)'

May 19, 2026

07:17 Top Supplements Today
08:23 NAD Hype vs Evidence

In this episode of the Flex Diet Podcast, I sit down with creatine researcher Dr. Darren Candow from the University of Regina to break down what the research actually says about creatine for muscle, performance, and body composition—plus the newer interest in brain health, aging, and longevity.

We dig into practical dosing (including higher-dose ideas for bone and brain), why timing probably doesn’t matter much, and what the data shows on safety, side effects, and common...