THE MYOCENTRIC VIEW OF CREATINE SUPPLEMENTATION MAY BE INCOMPLETE: BRAIN, BONE, HEART, IMMUNE SYSTEM?

madman · Mar 21, 2026

Thread 'Creatine Supplementation and the Brain'

Mar 21, 2026

* There is evidence that CrS increases brain creatine, but this response may be dose and/or duration dependent. CrS provides some benefits during acute periods of metabolic stress such as sleep deprivation, mental fatigue, and hypoxia. Emerging clinical data also suggest potential therapeutic effects from CrS for Alzheimer’s disease, major depressive disorder, and mild traumatic brain injury (mTBI), although findings across conditions remain preliminary and inconsistent. Further, CrS shows some promise for improving aspects of sleep quality. ...

madman · Apr 11, 2026

Thread 'The emerging and evolving evidence supporting creatine as an ergogenic aid: history and applications'

Apr 11, 2026

madman · May 19, 2026

Thread 'Creatine for Muscle, Bone, Brain & Longevity (Plus Caffeine, Dosing, and Safety)'

May 19, 2026

07:17 Top Supplements Today
08:23 NAD Hype vs Evidence

In this episode of the Flex Diet Podcast, I sit down with creatine researcher Dr. Darren Candow from the University of Regina to break down what the research actually says about creatine for muscle, performance, and body composition—plus the newer interest in brain health, aging, and longevity.

We dig into practical dosing (including higher-dose ideas for bone and brain), why timing probably doesn’t matter much, and what the data shows on safety, side effects, and common...

madman · May 29, 2026

Thread 'Creatine: New Insights for Muscle, Bone and Brain'

May 29, 2026

madman · Jun 15, 2026

Thread 'What is creatine really doing to your brain?'

Jun 15, 2026

What is creatine really doing to your brain? Top Creatine Researcher Dr Darren Candow reveals why 5g won’t reach your brain, how creatine may reverse sleep deprivation, and the 5 myths stopping millions from taking it!

Dr Darren Candow is a professor and Director of the Ageing Muscle and Bone Health Laboratory at the University of Regina, with 175 published research papers. He is a fellow and incoming Vice-President of the International Society of Sports Nutrition and was named on Stanford University's Top 2% Scientists list in 2025.
He explains...

madman · Jul 4, 2026

Thread 'Everything You Need to Know about Creatine'

Jul 4, 2026

In this episode, I sit down with Dr. Darren Candow, Professor in the Faculty of Kinesiology and Health Studies at the University of Regina, to take a deep dive into one of the most researched supplements available: creatine.

We discuss what creatine is, who can benefit from taking it, and why so many misconceptions still exist around its use. Dr. Candow breaks down the science behind creatine supplementation for athletes, active adults, older adults, vegetarians, vegans, and even clinical populations. We also tackle common concerns about weight gain, kidney...

madman · Aug 8, 2026

Thread 'Science of supplementation and strength'

Aug 8, 2026

This episode of Supervisor Talk features an in-depth conversation on the science of supplementation and strength. Host Flavia Rusterholz, a PhD student, interviews their supervisor, Dr. Darren Candow, a Professor in the Faculty of Kinesiology and Health Studies at the University of Regina. Dr. Candow is a leading expert in exercise physiology and sport nutrition, with over 18 years of experience in the field.

madman · Aug 20, 2026

Thread 'Creatine and Your Brain, Performance, Bone Health, and Sleep'

Aug 20, 2026

Dr. Candow

I think there is a huge amount of overhype on the brain

04:23 Creatine and Brain Health: Hype vs. Evidence

Dr. Darren Candow is one of the world’s leading researchers and authorities on creatine and joins me to separate what we know from what is still hype.

CHAPTERS

00:45 Creatine Basics and Muscle Saturation
04:23 Creatine and Brain Health: Hype vs. Evidence
08:51 Creatine and Sleep Deprivation
13:10 Concussions and Head Trauma
17:51 Creatine and Mental...