brain

* Steroid 5a-reductases (5aRs) catalyze the irreversible, NADPH-dependent reduction of A*-3-ketosteroids. This process regulates major steroid signaling pathways, including neurosteroid biosynthesis, androgen activation, and glucocorticoid metabolism. By governing these processes, 5aRs influence...

A moderate drinker takes a sobering look at everyone’s favourite social lubricant, asking the question: is any amount safe? In 2023, the Canadian Centre on Substance Use and Addiction pointed to the risk of consuming more than two standard drinks per week. In Proof: The New Science of Alcohol...

* The investigators plan to explore the direct role of these sex-specific hormones in regulating blood flow to the brain by blocking hormone production in healthy males and females and giving back testosterone and estrogen, respectively. The investigators will then conduct a range of tests to...

Dr. Darren Candow * 3-5 g is great for muscle * 8-10/8-12 g is good for bone * I think the sweet spot is 10 g for the whole body Join Dr. Altamash Raja and Dr. Darsh Shah on Medicine Redefined as they introduce Dr. Darren Candow, a leading researcher on creatine supplementation. The...

By THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION FEATURING JOSE ANTONIO, ANTHONY RICCI, DARREN CANDOW https://www.vumedi.com/video/the-myocentric-view-of-creatine-is-incomplete/ Prof. Darren Candow, PhD (University of Regina, Canada), an internationally expert in the field of creatine research...

Scientists discovered that more muscle and less hidden abdominal fat are linked to a younger biological brain age. Deep visceral fat appeared to accelerate brain aging, while muscle mass offered a protective effect. https://www.sciencedaily.com/releases/2025/11/251125112506.htm...

I (m, 37) take 20mg testosterone proprionate IM and 150 IU Hcg IM. I sometimes noticed under certain circumstances e.g. while travelling, that when I missed some sleep then the next day I didnt sleep really much more. And I just can go on and still look the same and dont feel too much tired or...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064763/ "Access of plasma steroids to target tissues and cells While measurements of free steroid concentrations remain the most robust indicator of the biological activities of plasma steroids (Vermeulen et al. 1999), adoption of the free hormone...

https://www.nature.com/articles/s41386-023-01570-y

Here is an interesting in vivo study with findings suggesting that lower levels of estrogen in the brain correlate to higher performance in varying forms of memory recall in men. @Cataceous @readalot @Nelson Vergel If a man were to experience brain fog and reduced memory recall while on TRT...

(Moving this to a new thread since it is a different topic) I am harping on this as I was doing pretty well on TRT with less than 100mg Testosterone Cypionate once a week plus 250IU HCG twice a week. Strong libido, good erections, etc. At that time, if I took 5mg cialis I could feel the effect...

A tip of the hat to "PakMan" at PeakT for the reference to this article. The underlying work is on mice, but may have implications for humans. Summary: Researchers have uncovered specific regions of brain tissue where aromatase is present, that drives male sexual desire. Aromatase converts...

Anyone have any experience with Dave Asprey's products? I'm curious about his upgraded aging supplement: http://www.upgradedself.com/products/bulletproof-upgraded-aging-formula Looks like Oxaloacetate is the key ingredient.