Testosterone Cypionate vs Enanthate : Formulation Differences

Getting answers, you have done excellent troubleshooting by trying both Testosterone Cypionate and Testosterone Enanthate to narrow down why you are having a local reaction to these medications. You are also correct that it's impossible to create a "jet" of oil with a syringe due to the fact that the liquid is too viscous and the needle bore too small to create a sufficient flow rate.

Any one of the ingredients in Testosterone Cypionate, which include Cottonseed Oil (carrier oil), Benzyl Benzoate (solubilizer), or Benzyl Alcohol (preservative) might cause the reaction. Since you already tried Testosterone Enanthate, which uses a different carrier oil (Sesame Oil) and preservative (Chlorobutanol) and still had the same local reaction I would say that it's not the carrier oil, solubilizer, or preservative that is causing it. It's doubtful that changing the oil is going to make any difference. Your body just doesn't like subcutaneous injections of oil-based testosterone. This is a common side effect for patients doing SQ injections of testosterone.

Gene, Bass and Jasen are correct in trying a different injection site (like your hip or buttocks), using a 29G 1/2'' syringe and/or using smaller, more frequent doses to solve the issue. Some use 27 gauge 1/2 inch on shoulders also.

If these solutions still don't fix the problem then I recommend doing intramuscular (IM) injections. If you have the same problem with IM injections then it's a good idea to use a different dosage form like Testosterone Cream.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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