Testosterone Cream Side Effects

mwsmith1972

New Member
Hi everyone
started TRT 1 week ago. Started off on a topical cream of 200mg, only doing one click every morning so this is 50mg I believe. So far my experience has been

  • feeling a little out of sorts
  • anxiety
  • lower libido
  • erections not as good when having sex
  • headaches
  • I have read different things
  • from this being normal until your body adjusts
  • give it 3-4 weeks
  • Some people have this reaction to creams and should try ciponate shots instead
looking for opinions

Thanks
 
Hi everyone
started TRT 1 week ago. Started off on a topical cream of 200mg, only doing one click every morning so this is 50mg I believe. So far my experience has been

  • feeling a little out of sorts
  • anxiety
  • lower libido
  • erections not as good when having sex
  • headaches
  • I have read different things
  • from this being normal until your body adjusts
  • give it 3-4 weeks
  • Some people have this reaction to creams and should try ciponate shots instead
looking for opinions

Thanks

A week of TRT is a blip on the timeline - it's a marathon you've entered and not a sprint. That said, topical applications of testosterone fail for a good many men, though that's seen more often in gels as opposed to compounded creams. You may have simply shut down your endogenous production of testosterone with the application of the cream, and you're now feeling the results of hypogonadism in a more profound manner. Testing will tell the story and your doctor may adjust the amount of cream you apply or transition you to shots.
 
Hi everyone
started TRT 1 week ago. Started off on a topical cream of 200mg, only doing one click every morning so this is 50mg I believe. So far my experience has been

  • feeling a little out of sorts
  • anxiety
  • lower libido
  • erections not as good when having sex
  • headaches
  • I have read different things
  • from this being normal until your body adjusts
  • give it 3-4 months
  • Some people have this reaction to creams and should try ciponate shots instead
looking for opinions

Thanks

Not a big fan of topicals, but not sure what you were expecting in a week. In bold is more in line with what you'll wanna do, and or, results of your follow up labs.
 
I think CW nailed it. Any natural T has been shutdown and you are just running on the cream. One click is pretty conservative. I recently changed TRT doctors and was put on one click of 200mg/ml My followup blood test came back TT300 FT 11 Since my natural production was ~260 I did not experience your symptoms. You Doc should let you get a followup bloodtest in 5-6 weeks.

Good luck give this some time.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Normal range: 300-1000 ng/dL

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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