Testosterone causing hypo symptoms

Fellas, often do you inject? Has it had a impact on your thyroid? I started in April of 2020, and last year around October I started having problems, and now I can connect them to TRT. It seems it somehow Impacting my thyroid function. I just went up to 112 mcg, and I dont have a problem with T3 conversion. My issue is actually secondary hypothyroidism due to a pituitary tumor.

After I inject i get fatigue for days. Brain fog, just off. This has went on for almost a year, and my hypothyroid symptoms have gotten worse, like Im not even on meds. Ive tried estrogen blockers, but it actually made symptoms worse, which comes to no surprise, since Im only on 75-100mg a week. My estrogen is not running high, looking at my estrogen ultrasensitive lab. Im thinking of going to injecting once every two weeks.

I know this is frowned upon in the TRT world, but I think its impacting my thyroid meds, cause Im still very hypothyroid, and im sitting at a Free T4 of 1.0(range .9-2.4) and my Free T3 is a 3.8, yet Im constipated, low heart rate, cold hands and feet, dry scalp, and depressed. Has this been the case with anyone else? Does anyone here inject only twice a month?
Do you also have muscle twitching or frequent urination as a symptoms?
 

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⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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