Low DHEA-S levels causing symptoms?

Sproatic

New Member
Hi forum.

I started TRT about 2 1/2 years ago due to low levels, no libido/ed, fatigue, low mood.

Initially I was on 150mg a week split twice, which put my levels too high out of reference range at trough. The above symptoms came back about 1 1/2 years ago.

I dropped down to 125mg which still had my TT/FT levels out of reference range at trough so have dropped down to 100mg a week split twice which puts FT/TT/E2 and bloods all within range.

I have still been experiencing fatigue and zero libido while on this dose, although it has only been 6 weeks. I decided to get other hormones checked and DHEA came back at 4.5 umol/L (reference range 4.8-13.9). I have never checked DHEA prior to this so have no reference point.


Research shows that low DHEA levels can cause the symptoms i'm experiencing, I doubt its from the FT/TT/E2 which are all within range. I am in Australia so DHEA isn't OTC here and I'm waiting to hear back if my clinic can prescribe which I am doubtful.

Has anyone been in a similar situation and how did they rectify it?
 
ahh, i dunno about that. isnt DHEA produced in testies? doesnt estrogen cause lowering DHEA? if werent hypogonadal perhaps less likely but yes it is VERY possible it lower DHEA..

Just run a test and see what your DHEA levels are :) best not to take hormones unless specific reason.

anyway, there is mental issue that can cause yoru symptoms, there is a whole cascade of hormones that gets lowered when on TRT so that could be it.

ask if can start low dose HCG as that helps libido :)

its normal to find other dopamine hits as you age vs sex.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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