T2dm

* They unpack the myths, the mechanisms, and the real impact behind these breakthrough therapies, and don’t shy away from the harder questions around access, affordability From Hollywood headlines to hospital hallways, the world’s sudden fascination with GLP-1s makes it hard to separate...

GLP-1 receptor agonists are one of the most revolutionary new classes of drugs in decades. In this episode of Healthy Dialogue, host Derek C. Angus, MD, MPH, sat down with Jens Juul Holst, MD, DMSc, and Lotte Bjerre Knudsen, DMSc, 2 pioneering scientists behind the discovery and development of...

* "One takeaway message from this is that ongoing engagement in a structured weight management program is extremely important for maintenance and the benefit of testosterone." Testosterone treatment may improve body composition, glucose metabolism and sexual desire in some older men at...

* T4DM RUNON sub-study extended the T4DM randomized, double-blind, placebo-controlled trial (n=1007) by 2 years, for a total of up to 4 years of treatment, without ongoing enrolment in the lifestyle program. Eligible and consenting participants (n=121) continued their original masked allocation...

Incretin-Based Therapies Goals for Today

Are you up to date on emerging pharmacologic therapies transforming obesity and type 2 diabetes care?

* Among the human studies, 9 evaluated testosterone levels (total and/or free), 6 reported on gonadotropins (LH, FSH), and 5 assessed clinical hypogonadal symptoms such as libido and erectile function. In total, 7 human studies demonstrated a statistically significant increase in testosterone...

Core Tip: The obesity pandemic has increased the prevalence of obesity-related health morbidities including male obesity related secondary hypogonadism (MOSH). Although weight loss is the ideal therapeutic option for MOSH, testosterone replacement therapy (TRT) is often necessary because of the...

Abstract Testosterone replacement therapy (TRT) is a crucial intervention for men diagnosed with hypogonadism,a condition characterized by inadequate testosterone production. As primary care NPs play an essential role in managing patients with hypogonadism, they must comprehensively understand...

In this first edition of The MCCRC Podcast, Dr. Kim Kuebler sits down with Dr. Julian L. Gallegos to talk about T2DM, Obesity, and Hypogonadism.

Abstract The physiological role of prolactin (PRL) in men is still not well defined. The pathological increase is characterized by sexual function impairment along with possible negative consequences in body composition and metabolic profile. Conversely, the clinical significance of reduced PRL...

This is gold A giant in the field of sexual health! Dr. Mulhall gets deep as usual! Adrenalin.....anti-erection chemical! @Nelson Vergel 00:33:51 Erectile Dysfunction *PDE5 inhibitors - POTENT ENDOTHELIAL PROTECTIONS * the penis is a BIG ENDOTHELIAL ORGAN * ENDOTHELIN is the MASTER...

Insulin plays a central role in blood glucose regulation, with insulin resistance contributing to the progression of prediabetes to diabetes, underscoring the importance of early intervention. Androgens, primarily synthesized in the testis under pituitary gland influence, impact male...

https://www.wkbw.com/news/local-news/need-for-fast-acting-insulin-disappeared-ub-professor-discovers-new-way-to-treat-type-1-diabetes AMHERST, N.Y. — Dr. Paresh Dandona at the University at Buffalo Jacobs School of Medicine may have discovered a medication that could change the way Type 1...

https://www.utsouthwestern.edu/newsroom/articles/year-2023/oct-estrogen-anti-diabetic-effects.html DALLAS – Oct. 23, 2023 – The quintessential female sex hormone estrogen stimulates cells that line blood vessels to deliver insulin to muscles, lowering blood sugar and protecting against Type 2...

https://www.healio.com/news/endocrinology/20230412/testosterone-therapy-may-benefit-men-with-diabetes-and-obesity-but-remains-controversial An increasing number of studies are reporting that testosterone therapy may not only normalize testosterone levels for men but may also provide...

Martin M. Miner, MD, Co-Director of the Men’s Health Center and Chief of Family and Community Medicine for Miriam Hospital in Providence, Rhode Island, and Clinical Professor of Family Medicine and Urology at the Warren Alpert Medical School of Brown University in Providence, discusses the role...

A Systematic Review of Studies Assessing Efficacy and Cardiovascular Safety of Testosterone Replacement Therapy in Men with Late‑onset Hypogonadism Due to Obesity ± Type 2 Diabetes Mellitus (2023) Vinod Abichandani, Atul Kalhan Background: There is a lack of consensus regarding the efficacy...

Effects of testosterone therapy in adult males with hypogonadism and T2DM: A meta-analysis and systematic review (2022) Satesh Kumar, Mahima Khatri, Rahat Ahmed Memon, Jordan Llerena Velastegui, Kristina Zumbana Podaneva, Daniela Benitez Gutierrez, Bilawal Nadeem, Akhil Raj Anumolu, Masood...

Obesity, type 2 diabetes, and testosterone in ageing men (2022) Gary Wittert · Mathis Grossmann Abstract In the absence of obesity, adverse lifestyle behaviours, and use of medication such as opioids serum testosterone concentrations decrease by only a minimal amount at least until very...

Morbidity and mortality in men: Role of androgens (2022) Giuseppe Fallara, Edoardo Pozzi, Christian Corsini, Federico Belladelli, Luca Boeri, Paolo Capogrosso, Francesco Montorsi, Andrea Salonia In this narrative review, we provide an overview of the current literature on male hypogonadism and...

LONG-TERM TESTOSTERONE THERAPY IMPROVES RENAL FUNCTION IN MEN WITH FUNCTIONAL HYPOGONADISM: EXPERIENCE FROM AN OBSERVATIONAL REGISTRY STUDY (2022) Karim Sultan Haider, Ahmad Haider, Gheorghe Doros, Farid Saad, Abdulmaged Traish Private Urology Practice, Bremerhaven, Germany; Department of...