Test results for 8mg daily blend (Enan + Prop)

[Seagal]

I am from Germany, and the product I use is called Tostran 2%. I find it has a little less alcohol content and it also dries out in a bit more time than usual.

Proviron @ 25mg should feel like something.

Also from Germany. Have the Testogel 1.62%.
I need 37mg proviron to feel an effect.
Gonna try the gel again.

 

[Willyt]

May I ask the reason for adding TNE? And why do you think it is better (or different) than TE/TP blend?

TNE definitely different from TP. Must faster hitting. A little goes a long way in my experience.

I tried both Suspension (water based) and TNE (oil based). @Cataceous started a thread on it here:

C

Thread 'Pharmacokinetic Profile of Testosterone Suspension: A Case Study'

Jun 27, 2025

Lately I’ve been insinuating that some testosterone suspension products may qualify as fast-acting, and therefore be in the same league as testosterone nasal gels and buccal troches. The “fast-acting” quality is important if the goal is to retain HPTA function in the presence of exogenous testosterone. It was time to put my money where my mouth is in order to see what’s actually happening when I inject testosterone suspension.

The results are promising, but not as definitive as I’d hoped for due to some confounding factors.

Materials and Methods

The product used was Pharmacom...

• Cataceous
• pharmacokinetics testosterone suspension
• Replies: 16
• Forum: Testosterone Basics & Questions

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[AndroChishti]

Also from Germany. Have the Testogel 1.62%.
I need 37mg proviron to feel an effect.
Gonna try the gel again.

Proviron is heavily dependent on underlying trt protocol. Since all of the androgenic effects of Proviron are mediated through liberating DHT bound to SHBG. On low dose protocols, there isnt enough DHT bound to SHBG begin with and hence non-significant androgenic boost/libido.

I have used upto 75mg a day of proviron but little to effects (positive/negative) but on a high DHT protocol (topical Test) even half a proviron tab provides god like confidence and libido.

 

[Cataceous]

.... Since all of the androgenic effects of Proviron are mediated through liberating DHT bound to SHBG. ...

In steady-state conditions Proviron should not have much influence on free DHT unless it is significantly affecting 5ar activity. But I would expect a reduction, if anything, due to possible negative feedback of higher DHT-like activity. Otherwise Proviron is just adding on to existing DHT activity. A widespread misconception is that a real or virtual (Proviron-driven) reduction in SHBG affects free hormone levels. This is not the case when a new equilibrium is established.

On the other hand, maybe you're suggesting the transient behavior is driving the subjective results. As Proviron levels rise there is some displacement of SHBG-bound DHT, temporarily increasing free levels. However, as Proviron falls free DHT decreases, even going below baseline before a return to the original equilibrium.

 

[AndroChishti]

In steady-state conditions Proviron should not have much influence on free DHT unless it is significantly affecting 5ar activity. But I would expect a reduction, if anything, due to possible negative feedback of higher DHT-like activity. Otherwise Proviron is just adding on to existing DHT activity. A widespread misconception is that a real or virtual (Proviron-driven) reduction in SHBG affects free hormone levels. This is not the case when a new equilibrium is established.

Assuming high free DHT doesnt have negative feedback loop-like activity on the 5ar enzyme. Why would decreasing SHBG not result in higher free androgen levels in a steady state environment? Is it because of increased liver clearance of androgens?

 

[AndroChishti]

On the other hand, maybe you're suggesting the transient behavior is driving the subjective results. As Proviron levels rise there is some displacement of SHBG-bound DHT, temporarily increasing free levels. However, as Proviron falls free DHT decreases, even going below baseline before a return to the original equilibrium.

This might be true, from my experience the positive effects of proviron seems to be transient and consistent usage always result in diminishing returns.

 

[Seagal]

In steady-state conditions Proviron should not have much influence on free DHT unless it is significantly affecting 5ar activity. But I would expect a reduction, if anything, due to possible negative feedback of higher DHT-like activity. Otherwise Proviron is just adding on to existing DHT activity. A widespread misconception is that a real or virtual (Proviron-driven) reduction in SHBG affects free hormone levels. This is not the case when a new equilibrium is established.

On the other hand, maybe you're suggesting the transient behavior is driving the subjective results. As Proviron levels rise there is some displacement of SHBG-bound DHT, temporarily increasing free levels. However, as Proviron falls free DHT decreases, even going below baseline before a return to the original equilibrium.

We were talking about achieving a peak thus no stable proviron levels. Works like a modulator to obtain quasi circadian level variations. That's how it feels for me.

 

[Cataceous]

Assuming high free DHT doesnt have negative feedback loop-like activity on the 5ar enzyme. Why would decreasing SHBG not result in higher free androgen levels in a steady state environment? Is it because of increased liver clearance of androgens?

Here is the reasoning: At steady state DHT is being cleared at the same rate it is being produced. If we can assume that clearance is proportional to the free hormone concentration then at steady state the free levels are always driven directly and proportionately by the production rate, independent of SHBG. I am applying the same argument that I've used for testosterone, explained in detail here:

C

Thread 'What affects free testosterone under TRT?'

Jun 20, 2025

I’ve covered this issue in many posts, but I thought it would be helpful to put more information in one thread and expand on the topic.

TL;DR: Under TRT, free testosterone is proportional to the dose rate and inversely proportional to the metabolic clearance rate. The liver accounts for most of the metabolism of testosterone, while conversion to DHT accounts for up to 10-20%, and conversion to other metabolites including estradiol is less than 2%. In steady-state conditions SHBG has little effect on free testosterone.

Background

There’s a basic equation in medical texts...

• Cataceous
• free testosterone liver metabolism shbg trt
• Replies: 7
• Forum: Testosterone Basics & Questions

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