T+HCG Protocols and AIs

JRos895

Active Member
Based on my readings, it seems like T mono protocols often do not require an AI, whereas HCG mono protocols often do require an AI.

Where do T+HCG protocols stand relative to those two protocols? Is 1000iu a week of HCG generally enough to necessitate the use of an AI in conjunction with say 100mg of T? I’m also referring to 1000iu of Pregnyl, not the weak stuff that Empower makes.
 
I’m sure that would be evaluated on an individual basis. Since the balls are responsible for around 20% of the aromatization that occurs in the body(before they get shut down) I’m sure that bringing them back online will bump up aromatization quite a bit. But whether or not that results in needing an AI…again that will come down to the individual. At some point though you have to ask yourself where you’re going to stop trying to make adjustments. You add test to boost your levels. Then you add HCG due to negative effects of test. Then you add an AI due to negative effects of HCG….then you add something due to negative effects of AI. Sure, perhaps you could pull off the balancing act of all three(and I’m actually considering trying that approach at some point), but would there be other ways for you to minimize the negative effects of each along the way?
 

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⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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