Hello,
I had blood work done in May and the reference range for Free T was- 35.0-155.0 pg/mL
Just had them done again in October and they changed to - 46.0-224.0 pg/mL
Anyone know why they changed this seems like a big jump?
No, the numbers are not particularly comparable. You might consider the percent of the reference range, and compare those values. But free testosterone measurements can be problematic in general, so I wouldn't rely on these. Your October value is probably calculated by the Vermeulen method, which has been useful, but is supplanted by the newer Tru-T method. I think overall it's preferable to measure total testosterone and SHBG, then use the Tru-T calculator. Total testosterone and SHBG tests tend to be more consistent, though it's still best to use the same lab and test types.So regardless of the reference range the actual numbers would be the same correct? For example if I am comparing my results from May to Oct. side by side to see any changes would this make sense?
Predict estradiol, DHT, and free testosterone levels based on total testosterone
This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.
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A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.
Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.
The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.
Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.
DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038