Quest Diagnostics - Estradiol Range is Inadequate

[TDM812]

See attached. I recentlay had bloodwork done, and my Ultrasensitive Estradiol came back at a 4. Typically, I would say this is low, however, they showed a range of <29. Accroding to them this was in the “Green” zone, and I am good to go. I am not buying it. What are your thoughts? I wasn’t feeling the best at the time, for a myriad of reasons, so I can’t comment on the presence of symptoms.

 

[Nelson Vergel]

LabCorp and Quest still have a very poor understanding of estradiol studies that show estradiol under 12 pg/ml may lead to bone loss and even fat gain in men and women. Their ranges really do not reflect the current status of the data.
Are you taking anastrozole ?

 

[Nelson Vergel]

The most respected estradiol study

Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men - PMC

Current approaches to diagnosing testosterone deficiency do not consider the physiological consequences of various testosterone levels or whether deficiencies of testosterone, estradiol, or both account for clinical manifestations. We provided 198 ...

www.ncbi.nlm.nih.gov

 

[TDM812]

LabCorp and Quest still have a very poor understanding of estradiol studies that show estradiol under 12 pg/ml may lead to bone loss and even fat gain in men and women. Their ranges really do not reflect the current status of the data.
Are you taking anastrozole ?

Thank you for responding. I am taking .25 eod. At the time of draw I was in the process of lowering my testosterone, so I am guessing I went low. I didn’t thin’ I went that low though.

 

[Nelson Vergel]

Thank you for responding. I am taking .25 eod. At the time of draw I was in the process of lowering my testosterone, so I am guessing I went low. I didn’t thin’ I went that low though.

Just be very careful

Google Search

 

[TDM812]

Just be very careful

Google Search

What would be considered a reasonable range using Ultrasensitive with Quest? I had bloodwork done today. I’ll post results as soon as they are available.

 

[Vince]

I believe you would like to keep your estrogen 60 pg/mL or under.

 

[Nelson Vergel]

Reas this and let’s discuss

How to Predict Estradiol and DHT at Different Testosterone Doses - Excel Male TRT Forum

I was able to come up with a table using the predictive model equation derived from data in this study: The Effects of Injected Testosterone Dose and Age on the Conversion of Testosterone to Estradiol and Dihydrotestosterone in Young and Older Men Summary This video discusses a research paper...

www.excelmale.com

 

[Mcgiver54]

Its a little uncomfortable switching to the Quest range from using Labcorp for years, how do you compare the two? the testosterone seems to be close, but the Estradiol seems off, mine came back 45 <OR=39. Is Quest using a different lab process? I may have a Labcorp test done just to compare. This is with no AI, Total T of 1300, I expected it to be higher, in the 60s at least since I was getting some joint pain.

 

[Nelson Vergel]

LabCorp and Quest sensitive estradiol tests use the same liquid chromatography method. Their estradiol ranges are arbitrary and derived from their own data bases. Obviously, most men using both labs are not on TRT and have lower T levels than most men on TRT here on ExcelMale.
In fact, 80 percent of sensitive estradiol blood test results of men using DiscountedLabs.com are “above range” when we were using LabCorp and now while we are using Quest. This is the most misunderstood variable in men’s health in my opinion.

 

[Nelson Vergel]

What I like about Quest is their nice color reports with graphs on each variables.