Pregnenolone pathways and outcomes

[cpc1]

I want to start by saying I'm really enjoying the discussions I'm seeing here along with the anecdotes. I believe I've reviewed all of the prior discussions on here regarding pregnenolone but I still have some questions. Does anyone habe any idea why an individual with undetectable pregnenolone levels and progesterone of .1ng/ml would not tolerate pregnenolone supplementation? Topical improves virtually every aspect of my life but seems to be forcing cortisol production. Oral is far too sedating and shuts off libido while causing depressive symptoms. Anyone have any thoughts or experiences?