Palmitoylethanolamide (PEA)

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DixieWrecked

Well-Known Member
Anyone hear of this or tried it? Obviously something is missing with me on TRT. Pregnenolone and DHEA help some but don't exactly hit the spot and have differnet effects for me that aren't just right. So somehow I stumbled upon this and its effect on nuerosteroids. People have mentioned that it helps their body aches, mental health, and libido. A few andecdotes hypothesize that this could be the missing link for the hormonal cascade that TRT inhibits. A guy on gootube (madman shoutout) states that this reversed his Post Finasteride Syndrome by getting his 5AR back on track and producing more allopregnenolone. Thoughts or experiences?


 
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FunkOdyssey

Seeker of Wisdom
The first study you linked there shows PEA is inhibiting 5-alpha reductase and androgen receptor expression in a rat model of BPH induced by testosterone propionate. That seems to run counter to the idea that it would be beneficial for libido in men on TRT.
 

DixieWrecked

Well-Known Member
yeah it seems that way, but apparently some suspect that the neurosteroids are key players in libido, which may be more obvious if you are lacking. Here is another study talking about its neuroprotective effects and effect on neurosteroids.

 

FunkOdyssey

Seeker of Wisdom
yeah it seems that way, but apparently some suspect that the neurosteroids are key players in libido, which may be more obvious if you are lacking. Here is another study talking about its neuroprotective effects and effect on neurosteroids.
There's only one way to find out right? Take some and let us know what happens.
 

Cataceous

Super Moderator
I've been taking 400 mg/d for three years now. I suspected I had some form of hyperalgesia, and using PEA correlated with a complete resolution of the issue. The possible amelioration of neurodegeneration also has some appeal.

Taken together, the results reported here strongly suggest that by activating multifactorial pharmacological targets and different cellular mediators, PEA could play a promising protective role in counteracting neuroinflammation related to major neurodegenerative diseases.
[R]​
 

DixieWrecked

Well-Known Member
I've been taking 400 mg/d for three years now. I suspected I had some form of hyperalgesia, and using PEA correlated with a complete resolution of the issue. The possible amelioration of neurodegeneration also has some appeal.

Taken together, the results reported here strongly suggest that by activating multifactorial pharmacological targets and different cellular mediators, PEA could play a promising protective role in counteracting neuroinflammation related to major neurodegenerative diseases.
[R]​
That's awesome. How long did it take for it to resolve your situation?
 

Kenp

Member
Anyone hear of this or tried it? Obviously something is missing with me on TRT. Pregnenolone and DHEA help some but don't exactly hit the spot and have differnet effects for me that aren't just right. So somehow I stumbled upon this and its effect on nuerosteroids. People have mentioned that it helps their body aches, mental health, and libido. A few andecdotes hypothesize that this could be the missing link for the hormonal cascade that TRT inhibits. A guy on gootube (madman shoutout) states that this reversed his Post Finasteride Syndrome by getting his 5AR back on track and producing more allopregnenolone. Thoughts or experiences?


Could you please link to the guy who reversed his PFS? I can't find him on youtube.
 
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