Palmitoylethanolamide (PEA) for pain

Anyone hear of this or tried it? Obviously something is missing with me on TRT. Pregnenolone and DHEA help some but don't exactly hit the spot and have differnet effects for me that aren't just right. So somehow I stumbled upon this and its effect on nuerosteroids. People have mentioned that it helps their body aches, mental health, and libido. A few andecdotes hypothesize that this could be the missing link for the hormonal cascade that TRT inhibits. A guy on gootube (madman shoutout) states that this reversed his Post Finasteride Syndrome by getting his 5AR back on track and producing more allopregnenolone. Thoughts or experiences?

Palmitoylethanolamide/Baicalein Regulates the Androgen Receptor Signaling and NF-κB/Nrf2 Pathways in Benign Prostatic Hyperplasia - PMC

Benign prostatic hyperplasia (BPH) is the most common benign tumor in males. Androgen/androgen receptor (AR) signaling plays a key role in the development of BPH; its alterations cause an imbalance between prostate cell growth and apoptosis. ...

www.ncbi.nlm.nih.gov

PEA(5ar1, neurosteroids)

what’s up, you people may know that 5ar-1 is the main subtype in brain areas related to sexual development like mPoa turns out this widely available supplement upregulates it by 97% even at very low dose as well as increasing Allo/DHP and other neurosteroids "Importantly, a single PEA EC50...

forum.propeciahelp.com

 

The first study you linked there shows PEA is inhibiting 5-alpha reductase and androgen receptor expression in a rat model of BPH induced by testosterone propionate. That seems to run counter to the idea that it would be beneficial for libido in men on TRT.

 

yeah it seems that way, but apparently some suspect that the neurosteroids are key players in libido, which may be more obvious if you are lacking. Here is another study talking about its neuroprotective effects and effect on neurosteroids.

Palmitoylethanolamide stimulation induces allopregnanolone synthesis in C6 Cells and primary astrocytes: involvement of peroxisome-proliferator activated receptor-α - PubMed

Palmitoylethanolamide (PEA) regulates many pathophysiological processes in the central nervous system, including pain perception, convulsions and neurotoxicity, and increasing evidence points to its neuroprotective action. In the present study, we report that PEA, acting as a ligand of...

pubmed.ncbi.nlm.nih.gov

 

yeah it seems that way, but apparently some suspect that the neurosteroids are key players in libido, which may be more obvious if you are lacking. Here is another study talking about its neuroprotective effects and effect on neurosteroids.

There's only one way to find out right? Take some and let us know what happens.

 

I've been taking 400 mg/d for three years now. I suspected I had some form of hyperalgesia, and using PEA correlated with a complete resolution of the issue. The possible amelioration of neurodegeneration also has some appeal.

Taken together, the results reported here strongly suggest that by activating multifactorial pharmacological targets and different cellular mediators, PEA could play a promising protective role in counteracting neuroinflammation related to major neurodegenerative diseases. ​

[R]​

 

I've been taking 400 mg/d for three years now. I suspected I had some form of hyperalgesia, and using PEA correlated with a complete resolution of the issue. The possible amelioration of neurodegeneration also has some appeal.

Taken together, the results reported here strongly suggest that by activating multifactorial pharmacological targets and different cellular mediators, PEA could play a promising protective role in counteracting neuroinflammation related to major neurodegenerative diseases. ​

[R]​

That's awesome. How long did it take for it to resolve your situation?

 

I used to take 1200mg for lower back pain, it was alright, didn’t remove the pain 100%… but that’s because I have some mangled discs.

 

That's awesome. How long did it take for it to resolve your situation?

As I recall it was in the range of 1-2 months. I think the standard advice is to give it 6 weeks before evaluating.

 

Anyone hear of this or tried it? Obviously something is missing with me on TRT. Pregnenolone and DHEA help some but don't exactly hit the spot and have differnet effects for me that aren't just right. So somehow I stumbled upon this and its effect on nuerosteroids. People have mentioned that it helps their body aches, mental health, and libido. A few andecdotes hypothesize that this could be the missing link for the hormonal cascade that TRT inhibits. A guy on gootube (madman shoutout) states that this reversed his Post Finasteride Syndrome by getting his 5AR back on track and producing more allopregnenolone. Thoughts or experiences?

Palmitoylethanolamide/Baicalein Regulates the Androgen Receptor Signaling and NF-κB/Nrf2 Pathways in Benign Prostatic Hyperplasia - PMC

Benign prostatic hyperplasia (BPH) is the most common benign tumor in males. Androgen/androgen receptor (AR) signaling plays a key role in the development of BPH; its alterations cause an imbalance between prostate cell growth and apoptosis. ...

www.ncbi.nlm.nih.gov

PEA(5ar1, neurosteroids)

what’s up, you people may know that 5ar-1 is the main subtype in brain areas related to sexual development like mPoa turns out this widely available supplement upregulates it by 97% even at very low dose as well as increasing Allo/DHP and other neurosteroids "Importantly, a single PEA EC50...

forum.propeciahelp.com

Could you please link to the guy who reversed his PFS? I can't find him on youtube.

 

He has a ton of stuff but these were the two that I watched before I started researching PEA on my own.

 

The first study you linked there shows PEA is inhibiting 5-alpha reductase and androgen receptor expression in a rat model of BPH induced by testosterone propionate. That seems to run counter to the idea that it would be beneficial for libido in men on TRT.

Baicalein suppresses the androgen receptor (AR)-mediated prostate cancer progression via inhibiting the AR N-C dimerization and AR-coactivators interaction

The study is using palmitoylethanolamide/baicalein that reduced dht and prostate weight. So it may be the baicalein that is a anti androgen and not the PEA.

 

I've been takung 450mg daily for roughly 2 months. Unfortunately i've noticed no difference in my aches and pains whatsoever, or any other effects.