Onset of feeling an injection

[Charliebizz]

What are the purported effects of TRT on cortisol? It suppresses or stimulates the adrenals?

As far as I know, the ACTH Stimulation test done at 8 am is the only valid way to assess adrenal function. Randomly checking blood cortisol at any time of the day outside of 8 in the morning or saliva tests are useless.

Most doctors are woefully ignorant about adrenal function and will only diagnose Addison’s Disease, which is a life threatening failure of the adrenals with very low to no cortisol. In fact, I was snapped at and insulted by a senior ER doctor after the 8th time in less than 2 months I brought my father into the emergency department for weakness, fatigue and dehydration and had the temerity to ask about adrenal function.

All I know is that I’ve never tested under 10 on am blood cortisol unless I was on trt and man did I feel it. However for some reason test cyp effected that way more then enanthate. I feel fine on enanthate without ssri. On cyp I legit couldn’t tolerate trt at all. I would have extreme fatigue ,twitching and a host of other issues. And my cortisol dropped to a 6. I wouldn’t put as much stick in the labs if the symptoms didn’t match.

 

[Charliebizz]

Interesting thought. I did a saliva test, but don't remember a whole lot about what it showed. Amitriptyline has been shown to reduce migraines, but I believe it is a TCA, not an SSRI. I was on it a while back. Ironically, I think I read something somewhere that it can suppress testosterone, and was one of my theories as to why I became hypogonadic in the first place. Tangentially, I have struggled with the thought that maybe now that I am off that drug and some other medication I was using for migraines, my natural levels might come back up to normal. I have done a few half-assed resets, but none that were legitimate attempts. At this point, I don't even care. I have accepted that I am hypogonadic, regardless of the cause, and am fine treating it. I just need to find the right treatment regimen, but I digress.

Will you post back here if you do this trial?

I’m in the same boat I’ve been searching for root cause for almost 15 years. I’m turning 40 in a few days. And I’m better on trt then off so I’ve resigned to the fact I’m going to be on it for life. That said I will never stop trying to feel better because I still have headaches and depression since quitting ssri. Could it still be ssri withdrawal? Some people say yes. But even ssri gets such a bad wrap but I think to many people start at way to high of a dose. I was only taking 2.5-5 mg of lexapro. Im going to start with 5mg of Prozac tomorrow (starting dose is 10) and I will 110% keep you updated.

 

[Fortunate]

I’m in the same boat I’ve been searching for root cause for almost 15 years. I’m turning 40 in a few days. And I’m better on trt then off so I’ve resigned to the fact I’m going to be on it for life. That said I will never stop trying to feel better because I still have headaches and depression since quitting ssri. Could it still be ssri withdrawal? Some people say yes. But even ssri gets such a bad wrap but I think to many people start at way to high of a dose. I was only taking 2.5-5 mg of lexapro. Im going to start with 5mg of Prozac tomorrow (starting dose is 10) and I will 110% keep you updated.

Why stop? Go back on if you felt better. Life is short. Keep trying to feel better.

 

[ajax31]

I’m in the same boat I’ve been searching for root cause for almost 15 years. I’m turning 40 in a few days. And I’m better on trt then off so I’ve resigned to the fact I’m going to be on it for life. That said I will never stop trying to feel better because I still have headaches and depression since quitting ssri. Could it still be ssri withdrawal? Some people say yes. But even ssri gets such a bad wrap but I think to many people start at way to high of a dose. I was only taking 2.5-5 mg of lexapro. Im going to start with 5mg of Prozac tomorrow (starting dose is 10) and I will 110% keep you updated.

I suggest you look into the effects of melatonin on adrenal function and cortisol secretion.

Melatonin Elicits Stimulatory Action on the Adrenal Gland of Soay Ram: Morphometrical, Immunohistochemical, and Ultrastructural Study - PubMed

Endogenous melatonin is a hormone secreted by pineal gland; it has several roles in metabolism, reproduction, and remarkable antioxidant properties. Studies on the melatonin effect on the adrenal glands which are important endocrine organs, controlling essential physiological functions, are...

pubmed.ncbi.nlm.nih.gov

 

[Charliebizz]

I suggest you look into the effects of melatonin on adrenal function and cortisol secretion.

Melatonin Elicits Stimulatory Action on the Adrenal Gland of Soay Ram: Morphometrical, Immunohistochemical, and Ultrastructural Study - PubMed

Endogenous melatonin is a hormone secreted by pineal gland; it has several roles in metabolism, reproduction, and remarkable antioxidant properties. Studies on the melatonin effect on the adrenal glands which are important endocrine organs, controlling essential physiological functions, are...

pubmed.ncbi.nlm.nih.gov

I honestly never liked messing around with melatonin