New to TRT. Received first labs. Concerned and need help.

Questions:

Why would my Total Testosterone only go up slightly while my Free shot up drastically? My previous Free Test was about 10. It's now almost 32. My previous Free % was 2.3. It's now 4.7. That's at 100mg/week of test cyp. Is that big of an increase at a low dose a bad sign?
Forgot to mention, This is meant for ME/CFS, but I think it's a really good comprehensive fatigue workup in general.

Also, to you original question, If it were me, I'd would give it 3 more months and see if it drops. Your hematocrit is fine, but if it's going to be in the back of your mind and bother you then it might be best to drop it to something like 90mg/week for piece of mind.

Speaking of mind, adding hCG at 500IU twice a week knocked a fair bit off my brain fog. Not a complete fix, but it helped enough that I'm continuing it while I'm waiting to see other specialists.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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