New to TRT. Need help understanding blood work

pobit

New Member
I started TRT about 4 months ago because I had low free T. I am 58 years old, exercise 6 days a week and in good health.
My regimen started with test cream 3 clicks daily =150mg, HCG 500iu twice a week, DHEA 20 mg daily, D3 5000iu daily, stinging neetle root 400mg daily.
After 2 weeks I started to feel better, more energy and sleeping better. Soon after that I begin to lose energy and lifting weights was becoming more difficult than before I started TRT. At about 4 weeks I felt so sick I thought I would have to go to the emergency room. My nipples hurt and I was in a daze from high E2. I talked to the doctor's office and they started me on anastrozole .125 twice a week. I also reduced the test cream to two clicks =100mg. I still had sore nipples and was still in a daze with the reduced test cream. Next I reduced the test cream to 1 click =50mg, reduced the HCG to 400IU twice a week, anastrozole .125 twice a week and stopped taking the DHEA.
The blood work posted here was drawn about two weeks after the last change.
Currently, I still have slight nipple soreness, no energy, lifting weights is difficult and I feel sore the next day after work outs, I also seem to have more inflammation than I did before I started TRT.
Need advice on what to try next.
Thanks, Pobit
 

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The only problem I see is the SHBG at 168 nmol/L, which when elevated will greatly decrease free testosterone. Your Free T needs to be within the 2-3 percent and is only 0.643%, you may need to push testosterone to supraphysiological levels to see much benefit. Regular blood donations will likely be needed to control hematocrit.

Checking blood work 2 weeks after a protocol change is pointless, it takes 6 weeks to reach stable blood testosterone levels.
 
Just an observation. When using cream/gel you don’t need to wait six weeks (this is for testosterone cypionate and might be shorter or longer depending on the ester). Testosterone cream/gel have testosterone not attached to any ester so half life is very short. This is why you usually have to apply twice daily to sustain blood levels.
 
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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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