New guy struggling with TRT

albatross

Member
Hi I have been on TRT for a year now and it's not really working out.

I first tried Sustanon, Anastrazole with Proviron but that was up and down and I could not stabilise either T or E2 and so was on one long rollercoaster the result is that a year later I was a couple of thousand pounds lighter and feeling no better.

I have now switched suppliers and I am now on Test E 50mg with HCG every 3.5 days after 6 weeks this has my Test at 800 ng/dl and free T at top of range as well. the trouble is my E2 has rocketed to 58 pg/mol and my Prolactin is way over range at 430 miu/L

I have not been able to speak to my doctor yet but I am not sure what the best way forward is - the prolactin is a concern as it always used to be in range, even when I was on Sustanon it was rock solid mid-range. Has the addition of HCG pushed it up?
 
Prolactin: Should Men with Erectile Dysfunction Be Tested ?

Substantial elevation in prolactin (>150 ng/mL) usually indicates a pituitary tumor. Very high levels of prolactin are associated with larger tumors. Prolactinomas are classified as microadenomas (<10 mm) and macroadenomas (>10 mm). The finding of a substantial elevation in blood levels of prolactin association with a pituitary lesion larger than 10 mm by radiographic analysis supports the diagnosis of a macroprolactinoma.

Modest levels of prolactin elevation (25&#8211;100 ng/mL) may be associated with several diagnoses. All other causes of hyperprolactinemia should be excluded before a tumor is considered. Primary hypothyroidism and chronic renal disease is associated with elevations in prolactin, probably because of altered metabolism or clearance of prolactin.

Some medications can increase prolactin blood levels in men, as shown in this table (source: Pharmacological causes of hyperprolactinemia
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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