Re-evaluating the role of Free Testosterone and SHBG

madman · Sep 2, 2025

Thread 'Importance of free testosterone measurement in assesssing androgen disorders'

Jun 15, 2025

As usual Nelson's house is where it's at!

Importance of free testosterone measurement in assessing androgen disorders

Thursday, March 27, 2025 at 1:00 PM Eastern Daylight Time.

event.on24.com

Testosterone imbalances affect men, women, and children differently. In males, testosterone deficiency (hypogonadism) can lead to low libido, fatigue, and muscle loss, while excess may contribute to aggression and cardiovascular risks. In females, testosterone excess (hyperandrogenism), often associated with polycystic ovary syndrome (PCOS) or adrenal disorders, can cause excess hair growth, weight gain, and menstrual irregularities. In children...

madman · Oct 9, 2025

Thread 'Dr. Shalender Bhasin: Optimizing the Diagnosis and Treatment of Hypogonadism 2025'

Oct 7, 2025

Nelson's house u heard it here first!

Dr. Shalender Bhasin!

* over the past 4 decades he has become a global leader in the biology of androgens, sarcopenia and aging related functional decline, his research has shaped clinical guidelines, its informed public health policy particularly around testosterone therapy, anabolic interventions and then the development of function promoting therapies

Pay attention to 25:40-34:36 of the presentation where he explains the importance of measuring free testosterone using a standardized Equilibrium Dialysis method!

Explains the...

madman · Nov 2, 2025

Thread 'Free T vs Total T - Cutoffs and Symptoms - Where Are the Data?'

Oct 13, 2025

25th Annual Fall Scientific Meeting of SMSNA!

Grapevine, Texas.

1:14:05-1:29:40

Recommendatios for Dealing with Free T

Concept of Total Hormonal Load

Keep in mind all those men with normal TT and high SHBG!

Reasonable, Evidence-based Recommendation for Managing T

madman · Nov 2, 2025

Thread 'How to Avoid a Mad "T" Party: Evaluation and Management of Male Hypogonadism'

Nov 2, 2025

One of the big boys in the field!

Dr. Anawalt!

Pay attention to the Q&A (43:20-56:30) especially when it comes to testing free testosterone!

43:20-46:27 - How do we assess for free testosterone?

* There's a direct antibody assay (IA) that measures free testosterone it is notoriously inaccurate and notoriously underestimates the true free testosterone as much as 30% so you should never use that but it is cheap, its easy, its quick so all labs offer it

madman · Dec 14, 2025

Thread 'The Changing Landscape in the Assessment of Steroid Hormone concentrations: is it time to let them free? (CLASH-free)'

Nov 8, 2025

* With CLASH-free, we will improve the clinical applicability of free steroid hormone concentrations in patients with specific conditions by using state-of-the-art methods.

* Formulas to estimate free steroid hormone concentrations are used instead, but their applicability in many clinical conditions is questionable, so is the correctness of therapeutic actions based on these results.

* We will improve current formulas to better estimate free hormone levels.

Research Portal - The Changing Landscape in the Assessment of Steroid Hormone concentrations: is it time to let them free? (CLASH-free)

Steroid hormones such as testosterone or vitamin D are vital forhuman physiology. In circulation, steroid hormones bind to specificbinding proteins and albumin, with only a small fraction circulatingfreely. The ‘free hormone hypothesis’ suggests that this free fractionis responsible for...

research.kuleuven.be

...

madman · 2026-02-14T09:56:08-0600

So many doctors still clueless when it comes to the most critical fraction free testosterone!

Shame on those still using/relying on the known to be inaccurate direct IA!

* The assays for measuring free testosterone are not standardized and have high levels of imprecision and inaccuracy. The reference ranges for free testosterone vary substantially among laboratories rendering it difficult to establish common diagnostic thresholds. Thus, there is a need to develop more advanced methods for measuring free testosterone and establish rigorously derived reference ranges.

Thread 'Endocrine Society Submits Comments to FDA Expert Panel on Testosterone Replacement Therapy for Men'

Yesterday at 10:25 PM

Society Submits Comments to FDA Expert Panel on Testosterone Replacement Therapy for Men

The Endocrine Society submitted comments on February 6 to the Food and Drug Administration (FDA) Expert Panel on Testosterone Replacement Therapy for Men.

www.endocrine.org