Natesto thread

stx359

Active Member
I have not seen or read much on here about Natesto. I am giving it a trial run and thought I would share my experiences in an effort to get some info out there.

Brief history:
On TRT for 20 months
High SHBG guy (44-50)
Best injection regimen was 80mg twice a week and HCG 150 IU daily (TT-1000, FT- 20)
Had amazing response in terms of body composition but always felt a little off otherwise, terrible sleep and acne issues.
Decided to give Natesto a try after hearing that in extended clinical trials patients consistently report regaining HPTA functionality.
Currently 2 months in - running TT of 850 and FT of 15 hour after application. Sleep restored which I am extremely happy about and acne is clearing up.
Libido and sensitivity have taken a little hit which doesn't surprise me as Natesto is in and out very quickly so I probably spend a longer part of the day with no or low testosterone compared to when I was injecting.
Draw blood tomorrow to check DHT, LH and FSH (LH and FSH were unreadable at baseline)
Plan to give this a 4 month trial and see if I can produce some FSH and LH.

I am interested to hear from anyone who has had a long run on Natesto and how it has worked. Also curious about adding a little Clomid to see if that will stimulate my HPTA. I am still taking daily HCG.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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