Guided_by_Voices
Well-Known Member
I did not feel anything but hopefully you will. I have been using low dose (50mg) niacinamide (NAD precursor) and apigenin (to block the breakdown of NAD) instead.
Thanks for the reply. What was ur NAD+ injection protocol? Like dosage and injection frequency
Do u notice anything from the niacinamide and apigenin?
Guided_by_Voices
Well-Known Member
I injected around 10mg twice a week at the same time as my HCG. That may not have been enough but I react well to low doses of things. My energy is pretty good on my protocol, but it's impossible to say how big the affect is. It's cheap and it can't hurt as far as I know, but it's not like I notice a sudden rush like what niacin produces, so I'm using it more based on theory than noticeable results.
Ya from my limited research in the past like 4-5 days, it seems like people usually use between 50-100mg per week. So maybe 20mg/ week was just too low to notice anything
BadassBlues
Well-Known Member
I just started myself; first injection was today. I plan on doing 50 mg 3 times a week for a few weeks and then bumping as needed to a max of 100 mg. I am also taking oral Nicotinamide Riboside with TMG and pterostilbene 2000 mg. This is a fairly aggressive protocol, but from what I have gathered from research is that it is best to do as much as can be tolerated (up to a limit). Some people get the IV drips with very high doses of 500-1500 mg at one time. That may be something I'll consider down the road. That method is pricey however, 500-600 per session.
I don't think 10-20 mg of NAD+ would be enough to feel anything. The precursor protocol does yield very good results though. That is why I am doing both.
www.empowerpharmacy.com
Dosage
NAD+ Injection is supplied by compounding pharmacies as a lyophilized (freeze-dried) sterile powder, typically in vials containing 500 mg or 1,000 mg of NAD+ per vial. The powder is reconstituted with sterile diluent (such as bacteriostatic water) before use to yield an injectable solution. Dosing regimens are individualized, as there is no one-size-fits-all dosage for NAD+ therapy. For general wellness or anti-aging purposes, providers often start with relatively low doses and adjust based on patient response. A common protocol, for example, is to begin with about 20 mg of NAD+ administered subcutaneously and gradually increase the dose over subsequent injections up to around 100 mg per injection. These injections may be given a few times per week; a usual schedule is 1 to 3 times weekly, depending on how well the patient tolerates NAD+ and the goals of therapy¹⁰. By ramping up the dosage slowly, patients can often avoid side effects like headache or nausea while still obtaining the energizing or cognitive benefits of NAD+. A maintenance plan might involve ongoing injections of 50-100 mg weekly or as directed by the prescribing provider. Importantly, NAD+ injections can be administered either in a clinic or self-administered at home if the patient has been properly instructed; the subcutaneous shots are given into the fatty tissue (for instance, the back of the arm or the abdomen) using a small insulin-type syringe for convenience.
In clinical research settings and certain intensive protocols (such as addiction detoxification), much higher NAD+ dosages have been utilized. For example, one early protocol for substance uses disorders employed 500-1,000 mg of NAD+ per day delivered by slow intravenous infusion over several consecutive days. In that setting, patients received high-dose NAD+ daily for about 4-10 days to alleviate acute withdrawal symptoms, followed by tapering to less frequent booster injections over the ensuing weeks. Such large doses are administered under direct medical supervision and via IV drip to ensure safety. Outside of specialized cases, most wellness protocols do not use daily high-dose NAD+; instead, they favor moderate doses spread out over time. Ultimately, the dosage and frequency of NAD+ Injection must be tailored to the individual’s needs, tolerability, and treatment objectives. A healthcare provider will determine the appropriate starting dose and titration schedule for each patient. They will also set an upper limit on the total weekly dose (for example, some experts recommend not exceeding ~300 mg per week in subcutaneous dosing without further evaluation) to minimize any risk of adverse effects. As with any compounded therapy, ongoing monitoring is part of dosage management; the provider may adjust the dose based on the patient’s energy levels, symptom improvements, or any side effects. Through this personalized approach, NAD+ Injection dosing can range from small booster doses to larger infusions, but always under professional guidance to ensure it remains safe and effective for the patient’s condition.
I don't think 10-20 mg of NAD+ would be enough to feel anything. The precursor protocol does yield very good results though. That is why I am doing both.
NAD+ Injection (Lyo)
Choose Empower Pharmacy for compounded NAD+ Injection. The leading accredited 503A and FDA-registered 503B compounding pharmacy.
www.empowerpharmacy.com
Dosage
NAD+ Injection is supplied by compounding pharmacies as a lyophilized (freeze-dried) sterile powder, typically in vials containing 500 mg or 1,000 mg of NAD+ per vial. The powder is reconstituted with sterile diluent (such as bacteriostatic water) before use to yield an injectable solution. Dosing regimens are individualized, as there is no one-size-fits-all dosage for NAD+ therapy. For general wellness or anti-aging purposes, providers often start with relatively low doses and adjust based on patient response. A common protocol, for example, is to begin with about 20 mg of NAD+ administered subcutaneously and gradually increase the dose over subsequent injections up to around 100 mg per injection. These injections may be given a few times per week; a usual schedule is 1 to 3 times weekly, depending on how well the patient tolerates NAD+ and the goals of therapy¹⁰. By ramping up the dosage slowly, patients can often avoid side effects like headache or nausea while still obtaining the energizing or cognitive benefits of NAD+. A maintenance plan might involve ongoing injections of 50-100 mg weekly or as directed by the prescribing provider. Importantly, NAD+ injections can be administered either in a clinic or self-administered at home if the patient has been properly instructed; the subcutaneous shots are given into the fatty tissue (for instance, the back of the arm or the abdomen) using a small insulin-type syringe for convenience.
In clinical research settings and certain intensive protocols (such as addiction detoxification), much higher NAD+ dosages have been utilized. For example, one early protocol for substance uses disorders employed 500-1,000 mg of NAD+ per day delivered by slow intravenous infusion over several consecutive days. In that setting, patients received high-dose NAD+ daily for about 4-10 days to alleviate acute withdrawal symptoms, followed by tapering to less frequent booster injections over the ensuing weeks. Such large doses are administered under direct medical supervision and via IV drip to ensure safety. Outside of specialized cases, most wellness protocols do not use daily high-dose NAD+; instead, they favor moderate doses spread out over time. Ultimately, the dosage and frequency of NAD+ Injection must be tailored to the individual’s needs, tolerability, and treatment objectives. A healthcare provider will determine the appropriate starting dose and titration schedule for each patient. They will also set an upper limit on the total weekly dose (for example, some experts recommend not exceeding ~300 mg per week in subcutaneous dosing without further evaluation) to minimize any risk of adverse effects. As with any compounded therapy, ongoing monitoring is part of dosage management; the provider may adjust the dose based on the patient’s energy levels, symptom improvements, or any side effects. Through this personalized approach, NAD+ Injection dosing can range from small booster doses to larger infusions, but always under professional guidance to ensure it remains safe and effective for the patient’s condition.
BadassBlues
Well-Known Member
Separately for sure.
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