I mentioned in another thread a supplement I was using that has had remarkable benefits. To introduce this topic, I want to briefly discuss a prominent researcher in the field of anti-aging.
David Sinclair was a leading researcher into sirtuin boosting supplements (aka resveratrol), and this work led to isolating a sirtuin boosting compound, which Sinclair still uses today, according to a recent interview on the Joe Rogan podcast. In 2009 Sinclair decided that proving sirtuin-boosting compounds can treat human disease be left up to GlaxoSmithkline, which bought Sinclair's Sirtris Pharmaceuticals for $720 million, which Sinclair co-founded in 2004. Sinclair got $8 million from the deal. Interestingly, Glaxo recently announced they were abandoning their investment into further developing proprietary sirtuin boosting drugs.
Naturally Sinclair has moved onto other areas. Primarily, touting the anti-aging benefits of boosting NAD+. I do not want to delve deeply into the biochemistry or physiology of this, suffice to say it does look like a very promising therapeutic approach. What is good about Sinclair's involvement is that it seems to have stimulated more broad-based research into NAD+. And perhaps somewhat predictably, Sinclair is now touting another proprietary NAD+ precursor known as NMN. Anti-agers have been on to the benefits of boosting NAD+ for some time. Another proprietary and fairly expensive precursor supplement touted for this purpose was nicotinamide riboside.
But I am here to tell you there is a better way. The most recent independent research data appears to show that both these expensive precursors are converted quickly in the body to niacinamide. And that niacinamide in turn is also converted to NAD+. And this leads to restoration of more youthful levels and the associated benefits. And niacinamide is widely available as an inexpensive form of vitamin B3 supplement.
Now what I have found, there is a right way and a wrong way to go about this. It is not a more is necessarily better supplement. In fact there is some information that too much niacinamide can lead to liver issues, or that when niacinamide levels are constantly maintained at high levels, that NAD+ levels could be temporarily suppressed. These are the reasons it is important to know how to go about supplementing niacinamide.
So I want to share what has worked for me. I could elaborate on what I refer to as the circadian reflex, whereby through essential innate and autonomic nervous system behavior, our physiologies are programmed for catabolic activities in the day and anabolic repair later in the day. You want to push and entrain those natural rhythms to work in your favor.
Take niacinamide early in the day and avoid it at night. Do not keep niacinamide levels high 24x7. Use it to coil the circadian reflex in your favor. As your body converts the niacinamide to NAD+ the anabolic repair mechanisms are entrained. Supplement niacinamide with 1-2 doses of 250 to 500 milligrams before noon and before your workouts (also try to exercise in the AM), to entrain the natural circadian patterns to be initially energized for activity and then wind down for repair. This approach is safe and effective.
You can find what I use here on Amazon.
Plenty of research on these topics is out there via Pubmed and various distillers.
I am hitting PRs for natural lifting at age 59.5 and am mostly pain free with old injuries healing up. It is a slow process that takes place over several months and you should begin to notice. As with many things along these lines, the benefits may be more pronounced the older you are. But I do wish I could have begun nipping declining NAD+ levels in the bud when I was younger, and who knows, I may not have grey hair now.
David Sinclair was a leading researcher into sirtuin boosting supplements (aka resveratrol), and this work led to isolating a sirtuin boosting compound, which Sinclair still uses today, according to a recent interview on the Joe Rogan podcast. In 2009 Sinclair decided that proving sirtuin-boosting compounds can treat human disease be left up to GlaxoSmithkline, which bought Sinclair's Sirtris Pharmaceuticals for $720 million, which Sinclair co-founded in 2004. Sinclair got $8 million from the deal. Interestingly, Glaxo recently announced they were abandoning their investment into further developing proprietary sirtuin boosting drugs.
Naturally Sinclair has moved onto other areas. Primarily, touting the anti-aging benefits of boosting NAD+. I do not want to delve deeply into the biochemistry or physiology of this, suffice to say it does look like a very promising therapeutic approach. What is good about Sinclair's involvement is that it seems to have stimulated more broad-based research into NAD+. And perhaps somewhat predictably, Sinclair is now touting another proprietary NAD+ precursor known as NMN. Anti-agers have been on to the benefits of boosting NAD+ for some time. Another proprietary and fairly expensive precursor supplement touted for this purpose was nicotinamide riboside.
But I am here to tell you there is a better way. The most recent independent research data appears to show that both these expensive precursors are converted quickly in the body to niacinamide. And that niacinamide in turn is also converted to NAD+. And this leads to restoration of more youthful levels and the associated benefits. And niacinamide is widely available as an inexpensive form of vitamin B3 supplement.
Now what I have found, there is a right way and a wrong way to go about this. It is not a more is necessarily better supplement. In fact there is some information that too much niacinamide can lead to liver issues, or that when niacinamide levels are constantly maintained at high levels, that NAD+ levels could be temporarily suppressed. These are the reasons it is important to know how to go about supplementing niacinamide.
So I want to share what has worked for me. I could elaborate on what I refer to as the circadian reflex, whereby through essential innate and autonomic nervous system behavior, our physiologies are programmed for catabolic activities in the day and anabolic repair later in the day. You want to push and entrain those natural rhythms to work in your favor.
Take niacinamide early in the day and avoid it at night. Do not keep niacinamide levels high 24x7. Use it to coil the circadian reflex in your favor. As your body converts the niacinamide to NAD+ the anabolic repair mechanisms are entrained. Supplement niacinamide with 1-2 doses of 250 to 500 milligrams before noon and before your workouts (also try to exercise in the AM), to entrain the natural circadian patterns to be initially energized for activity and then wind down for repair. This approach is safe and effective.
You can find what I use here on Amazon.
Plenty of research on these topics is out there via Pubmed and various distillers.
I am hitting PRs for natural lifting at age 59.5 and am mostly pain free with old injuries healing up. It is a slow process that takes place over several months and you should begin to notice. As with many things along these lines, the benefits may be more pronounced the older you are. But I do wish I could have begun nipping declining NAD+ levels in the bud when I was younger, and who knows, I may not have grey hair now.
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