NAD, Hype Or Miracle Molecule?

What is the endpoint you are looking for?

A good Q, and that's just it: what are the measurable endpoints demonstrating actual benefits? That remains unclear. Majority of the data is under the low tissue levels of NAD+ are associated with X bad things so raising NAD+ levels back to that of younger people will prevent bad things/teat bad things type. Preliminary data on animals looked promising, small low powered limited human studies showed some promise. A whole lot more data is needed. On paper holds real promise, but data no where near what's needed to demonstrate that.
 
That sounds very abstract to me. I take many pills and none without a specific endpoint. I will wait until human-related endpoints are defined. Longevity is an impossible endpoint to measure for an n=1
 
That sounds very abstract to me. I take many pills and none without a specific endpoint. I will wait until human-related endpoints are defined. Longevity is an impossible endpoint to measure for an n=1

Covered somewhat in my article. There may be new data since I wrote it, not sure. Due mostly to cost combined with lack of useful human data, I don't use NR myself currently.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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