lowering E2

Jntsrgn

Member
After stable dosing for over a year, my E2 crept up over 130 (usually 50) and resulted in ED but no other symptoms. After reducing my T dose by a third from 180 to 120, I am still maintaining Total T of 1200 and Free T of 400, but my E2 was still 101. I started on 0.5 Anastrazole Mon and Th for a total of 1mg per week. I have only taken 2 doses. My issue is that I have developed crushing all day headaches that require steady use of Mortin. Nothing else is different other than the Anastrazole.

Any one else ever have this side effect from Anastrazole? I can't leave the E2 that high, but the headache is bullshit.
 
After stable dosing for over a year, my E2 crept up over 130 (usually 50) and resulted in ED but no other symptoms. After reducing my T dose by a third from 180 to 120, I am still maintaining Total T of 1200 and Free T of 400, but my E2 was still 101. I started on 0.5 Anastrazole Mon and Th for a total of 1mg per week. I have only taken 2 doses. My issue is that I have developed crushing all day headaches that require steady use of Mortin. Nothing else is different other than the Anastrazole.

Any one else ever have this side effect from Anastrazole? I can't leave the E2 that high, but the headache is bullshit.
In my experience Anastrozole is best dosed EOD due to its short half life. The body reacts better to micro doses. Try .125 EOD. You also have room to LOWER your dose. It took me too long to learn bigger doses is Testosterone are not always better.
 
In my experience Anastrozole is best dosed EOD due to its short half life. The body reacts better to micro doses. Try .125 EOD. You also have room to LOWER your dose. It took me too long to learn bigger doses is Testosterone are not always better.
Yep. I’m in the process of lowering. I cut T by 1/3 and HCG by 1/2 but E2 still way high.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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